The BiosearchTech Blog

Originally developed in the early 1990s, aptamers have long been heralded as an antibody alternative for detection ...

When it comes to oligonucleotide therapeutics, the challenge has always been how to deliver an intact oligo to the ...

Molecular testing protocols for pathogen detection and diagnosing human diseases require reliable and high-quality ...

Modern agriculture faces unprecedented challenges: increasing global temperatures, water scarcity, less arable land to ...

New approaches that use aptamers as targeting agents may open the door to wider clinical use in the future

Let the application be your guide when deciding between LNA, MGB and BHQplus The many different chemistries available ...

Since 13 May 2022, reports of monkeypox cases began to appear globally in regions not endemic to the monkeypox virus.1 ...

This is the second blog in a two-part series exploring solutions for infectious diseases in aquaculture. In the first ...

Since early 2020, diagnostic laboratories have had to manage patient sample quantities being in a state of flux. Demand ...

This is the first blog in a two-part series exploring solutions for infectious diseases in aquaculture. This blog post ...

What’s changed for clinical labs as we enter the third year of COVID-19 testing? COVID-19, the illness caused by ...

While both centralised and decentralised molecular diagnostics (MDx) testing models play an important role in patient ...

This is the second blog in a two-part series exploring how oligonucleotide modifications can support the advancement of ...

African oil palm (Elaeis guineensis Jacq.) is a highly productive perennial crop that is used widely in food, ...

The COVID-19 pandemic has accelerated the uptake of point of care testing (POCT), with simple, user-administered tests ...

This is the first blog post in a two-part series exploring how oligonucleotide modifications can support the ...

But measurement science could help steer us in a better, more informed direction COVID-19 tests can indicate the ...

More innovative applications for Black Hole Quencher (BHQ) dyes In imaging and detection assay development, innovative ...

Rice is the primary staple for more than half the world's population.1 With so many people relying on the crop for ...

What’s changed for clinical labs as we enter the third year of COVID-19 testing? COVID-19, the illness caused by ...

The emergence of the Omicron lineage has quickly escalated to be a variant of concern by the World Health Organization ...

What’s changed for clinical labs as we enter the third year of COVID-19 testing?

This is the final blog post in a three-part educational series about best practices for in-house oligonucleotide ...

On 22 November 2021, The Network for Genomics Surveillance in South Africa detected a new SARS-CoV-2 variant, named the ...

The decisions made by molecular breeding programmes have a substantial impact on the world around us, from productivity ...

We're excited to announce that the proposal to extend certain key provisions of the In Vitro Diagnostic Regulation ...

A fourth wave of COVID-19 has already emerged in many countries and a newly classified variant of concern, Omicron ...

Many cultivated crops with agronomic significance, including wheat, peanut, oat, banana, potato, coffee and strawberry, ...

This is the first blog post in a two-part series highlighting how Black Hole Quencher™ dyes can be incorporated into ...

This is the second blog post in a three-part educational series about best practices for in-house oligonucleotide ...

SARS-CoV-2 mutations and associated new variants are being reported regularly in the media and scientific literature. ...

When results from your qPCR assays aren’t quite what you expected, it can be challenging to understand what went wrong. ...

In September 2021, Delta persists as the most prevalent variant worldwide1 due to its high infectivity, causing surges ...

A shortcut to understanding how to prepare for IVDR In today’s global environment, even small regulatory changes in one ...

This is the first blog post in a three-part educational series about best practices for in-house oligonucleotide ...

Aquaculture breeding programmes adopt genomic technologies, including genotyping, to increase genetic gain for specific ...

The COVID-19 pandemic brought tremendous change to the molecular diagnostics (MDx) industry, delivering opportunities ...

As SARS-CoV-2 variants continue to threaten public health, officials are looking beyond clinical tests to track ...

Emerging SARS-CoV-2 variants of concern and variants of interest are defined by agencies such as the World Health ...

Informed plant breeding decisions help drive the field of agrigenomics towards ever-increasing agricultural ...

A common mistake when initiating an agrigenomics project is failing to consider specific sample composition before ...

The global demand for fish and fish products continues to increase as consumers focus on health-conscious ways to add ...

As the global population gains greater access to vaccines for COVID-19, scientists and health officials continue to ...

Researchers have identified several variants of SARS-CoV-2 since they sequenced the original viral strain responsible ...

In breeding programmes, selections based on a single or small number of markers to target traits in marker assisted ...

Clinical and diagnostic labs worldwide are still experiencing supply chain challenges with their SARS-CoV-2 testing ...

“In July of 2015, I was a member of the radish genome project team. My task was to examine genetic diversity of radish ...

Darshna "Dusty" Vyas has been a Senior Scientist at LGC specialising in plant genetics for the past 8 years Her ...

Following up with the panelists from our recent COVID-19 webinar, Part 3 of 3 In the previous two blog posts in this ...

Following up with the panelists from our recent COVID-19 webinar, Part 2 of 3 In the face of a rapidly evolving ...

Following up with the panelists from our recent COVID-19 webinar, Part 1 of 3 The COVID-19 pandemic has presented ...

As countries worldwide begin to ease lockdown restrictions during the pandemic and prepare to return to “normal” ...

Brassica rapa crops are important sources of food, feed, and fuel in many parts of the world and provide a unique ...

It may seem strange that a company known for transforming the global seed breeding industry is uniquely positioned to ...

We’re not rejecting you, just your oligo PCR is arguably one of the most enabling technologies of modern molecular ...

LGC, Biosearch Technologies is excited to announce the expansion of SeqSNP targeted genotyping by sequencing (GBS) ...

On March 25, 2020, the US Food and Drug Administration (FDA) held the first of a series of virtual town halls they will ...

Back in September 2018, LGC acquired Lucigen Corporation. The ISO accredited site is based in Middleton, Wisconsin and ...

In the nearly three months since the first confirmed case of COVID-19, the outbreak has become a global crisis, with ...

*Since the original publication of this blog, LGC, Biosearch Technologies is now the only acceptable commercial ...

Coronavirus, or COVID-19, is an infectious virus that is spreading rapidly around the world and the World Health ...

The development of new genomic sequencing techniques and bioinformatics analysis in the last decade has led to massive ...

Best practice in sample collection for SeqSNP targeted genotyping by sequencing projects When good goes in, great comes ...

Livestock supports the livelihoods and food security of almost 1.3 billion people worldwide, contributing 40% of the ...

We've heard it said for years, "TV will rot your brain". But in the case of our three colleagues below, that ...

“Experience of artificial fertilisation, such as is effected with ornamental plants in order to obtain new variations ...

Blindness, cardiovascular disease, and stroke are all long-term health problems that can be caused by type 1 diabetes ...

Plant and animal breeding programmes often take generations to improve quality and yield but using a genotyping ...

Genomic selection: 6 factors to consider when choosing between targeted GBS and microarrays

Food security is a major global threat and traditional methods of plant and animal breeding will not be sufficient to ...

Diversity is the spice of life and is also key to breeding rice that delivers increased yields. Rice is a crucial ...

While the science of pharmacogenomics has been around for years, its popularity is starting to pick up steam as ...

Imagine a time capsule the size of a shoebox that holds all the information currently on the internet that can be ...

Ever wake up in the morning just feeling like a rock star, or maybe like Francis Crick, Rosalind Franklin or Maurice ...

To truly understand complex diseases such as cancer, scientists need access to tools that don’t just average data ...

Ask any little girl what they want to be when they grow up and you may hear things like, princess, ballerina, pop star, ...

Stellaris® RNA FISH (fluorescence in situ hybridization) is an RNA visualization method that allows simultaneous ...

With the global population predicted to reach 9 billion people within the next 35 years, we will need to double the ...

Wheat is one of the three most important crops for human and livestock feed. With an ever-increasing global population, ...

Our world population is growing at a tremendous rate and by 2050, Africa’s population alone is set to hit over 2.5 ...

3.2 billion people across 106 countries and territories, live in areas at risk of malaria transmission. The serious and ...

Recently LGC Genomics hosted a lunch and learn Stellaris® seminar at the Helen Diller Cancer Institute at UCSF with our ...

LGC's Genomics Division has signed a memorandum of understanding (MOU) with Chinese health management expert Personal ...

A recent study coordinated by LGC and published in the journal Analytical Chemistry, has demonstrated the potential of ...

New research has, for the first time, found evidence suggesting the molecular epidemiology of how the Zika virus ...

It’s time to forget what you know about heating your PCR plates for end-point PCR. Water is the way to go. Where ...

Demand for maize is increasing due to an increased number of people transitioning to meat-based diets driving demand ...

The advent of and ongoing improvements to next-generation sequencing technologies is driving the continuing and ...

Nature versus nurture. It’s a tale as old as time. When Craig Venter made the comment after the human genome sequence ...

Many areas critical to improved agricultural production require robust and scalable genotyping platforms to enable the ...

Screen more markers faster and bring crops with superior traits to the market quicker.

It seems everyone wants to do more with less, and automate the process as well. But this can cause a number of ...

It wouldn't be fair to close out 2016 without showcasing the stellar year that Stellaris® RNA FISH has had. Take a ...

With the discovery of the double helix, we learned how genes are copied and how genetic information was passed on. From ...

The secret of life. That’s what Francis Crick and James Watson claimed they had discovered back in Cambridge, England ...

In the early 1900s, scientists found that the function of genes was to make proteins, disproving the earlier idea that ...

The strands of DNA in your cells are organized into pieces called chromosomes. Chromosomes are further organized into ...

Researchers from the Baker IDI Heart and Diabetes Institute in Melbourne, Australia have blamed a default autocorrect ...

As the Zika virus outbreak spreads, a wave of international concern has grown, and scientists have scrambled to ...

We continue our “Know Your Oligo Mod” series with another versatile custom oligonucleotide modification: the Thio C6 ...

Modern breeding methods rely on the identification and utilization of molecular markers associated with traits ...

For DNA Technology’s existing customers, don’t fret! The online ordering process will remain the same, as will the team ...

OLIGO SYNTHESIS PHOTO GLIMPSE We’ve recently captured our talented manufacturing teams hard at work building oligos. ...

LGC Biosearch Technologies has developed a new qPCR probe format powered by Black Hole Quencher® technology known as ...

At this year’s 24th annual Plant & Animal Genome (PAG) conference, LGC Biosearch Technologies hosted a symposium ...

Here is the final installment of our “Imaging Stellaris Assays” blog series. In our two previous posts, we’ve gone over ...

Stellaris® RNA FISH is a novel technology that allows for the detection of single or clustered RNAs in fixed cells and ...

This week, we continue our Know your oligo mod blog series and we will focus on a very basic, yet extremely versatile ...

Here we continue our “Imaging Stellaris Assays” blog series. We last left off talking about the most important ...

The cleavage and polyadenylation event, the final trimming in the molecular mRNA barbershop, normally releases both the ...

Stellaris® FISH is an RNA detection technology performed by means of in situ hybridization. This technology and all of ...

Chemically synthesized DNA has become an indispensable tool for molecular biologists in the fields of medicine, ...

In this instalment, we will cover the basics of LGC Biosearch Technologies’ line of proprietary non-fluorescent ...

Studying the expression level of RNA transcripts is often complicated by the fact that many DNA sequences are ...

Gene expression and molecular biology research in vision and ophthalmology presents unique challenges to researchers ...

Since its inception, qPCR has been recognized as a powerful molecular method. However, the application of this ...

This past April, Biosearch attended the American Association of Cancer Research (AACR) conference in Philadelphia, PA ...

In the setup of a qPCR experiment, one of the first decisions to make is which detection method to use. This generally ...

A recent paper published in Molecular Cell by Dimitrova et al. from the lab of Dr. Tyler Jacks at MIT, used Stellaris® ...

Buffers are often overlooked and taken for granted until the day comes when a peculiar result is observed and its ...

This post in our continuing series, “Know your oligo mod” will cover phosphorothioate bonds, which are available for ...

In a recent webinar, Dr. James Willey describes a two color fluorometric assay for more robust quantitation of nucleic ...

Single Nucleotide Polymorphisms (SNPs) have been widely studied for over 15 years, and have applications in forensics, ...

The chemical synthesis of oligonucleotides allows for the incorporation of a wealth of modifications to an oligo ...

Neuroscience gene expression research can come with many hurdles, especially when working with brain tissue or mixed ...

Biosearch Technologies has launched qPCRdesign.com, a new microsite targeted specifically for your quantitative PCR ...

Different oligonucleotide manufacturers deliver probes and primers in a variety of different measured units including ...

The largest recorded Ebola Virus Disease outbreak in history continues to devastate the West African region. This ...

Don’t waste time performing an extra step. Cut back on pipetting and order a ValuMix™ Assay to have your probes and ...

Do you remember when the most popular method of DNA amplification involved multiple hybridizations, followed by single ...

A "Referral from the Doctor" Blog Article- Quantitative reverse transcription polymerase chain reaction (RT-qPCR) is a ...

Biosearch Technologies, Inc. (Biosearch) announced today that the company has implemented a rapid response to the ...

Stellaris probe sets targeting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA were among the first designed at ...

Biosearch Technologies, Inc. (Biosearch), a leading supplier of sophisticated oligonucleotide components to the rapidly ...

Biosearch Technologies, Inc. (Biosearch), a leading supplier of sophisticated, custom-manufactured oligonucleotides and ...

Biosearch Technologies, Inc. (Biosearch), a leading supplier of sophisticated oligonucleotide components to the rapidly ...

Image courtesy of: http://www.cdc.gov/h1n1flu/images.htm A cooperative effort between researchers at Mount Sinai ...

Non-squamous, Non-small cell lung cancer (NSCLC), the most common cause of death in the US and globally, has recently ...

Fluorophores are molecules that can absorb light energy in a process called excitation and re-emit light energy at a ...

A "Referral from the Doctor" Blog Article- The mathematical model of PCR is based on the assumption that each DNA ...

Biosearch Technologies is starting a new sister blog at singlemoleculefish.com where all articles will focus on topics ...

A "Referral from the Doctor" Blog Article- Fluorescent probes are used in biochemical assays to monitor specific events ...

A "Referral from the Doctor" Blog Article- Quantitative real-time PCR (qPCR) was developed as a means to detect the ...

If you run quantitative real-time PCR (qPCR) assays, the chances are that you’ve seen some strange looking ...

I’ve always wondered why scientists have earned themselves this infamous reputation of dressing poorly and ...

A "Referral from the Doctor" Blog Article- ROX in qPCR Quantitative real-time RT-PCR was developed as a means of ...

Biosearch Technologies, Inc. (Biosearch), a leading supplier of sophisticated oligonucleotide components to the rapidly ...

Biosearch Technologies is proud to sponsor the first IVD Technology Virtual Conference and Tradeshow. This free online ...

Biosearch Technologies today announces that it has entered into a new license relationship with QIAGEN (NASDAQ: QIA, ...

When the polymerase chain reaction (PCR) was first described, the Klenow fragment of Escherichia coli DNA Polymerase I ...

It can be difficult to transition a product from research to commercialization. It’s simply not feasible to conduct ...

A "Referral from the Doctor" Blog Article- Research trends in laboratories today increasingly steer towards gene ...

A "Referral from the Doctor" Blog Article- Scorpions®Primers are dual-labeled FRET probes that combine a Molecular ...

A "Referral from the Doctor" Blog Article- Molecular Beacons are a special type of dual-labeled oligonucleotide probe. ...

A "Referral from the Doctor" Blog Article- A BHQ® probe is a dual-labeled oligonucleotide covalently labeled with a ...

A "Referral from the Doctor" Blog Article- The aim of the Polymerase Chain Reaction (PCR) method is to amplify or ...

At the third qPCR Symposium, held November 9th -12th in Millbrae, CA, ETS laboratories (ETS) scientist Rich DeScenzo ...

A "Referral from the Doctor" Blog Article- Genomic DNA contamination has been a hot topic for qPCR researchers since ...

By now, you've no doubt read about the reductions in error, cost and time that can be achieved by multiplexing ...

A "Referral from the Doctor" Blog Article- ε = m.c.2 (shall I explain? slope efficiency equals manageable and ...

A "Referral from the Doctor" Blog Article- Competitive qRT-PCR has become a lost art. Early titans of probe-based PCR ...

A "Referral from the Doctor" Blog Article- Ribosomes are comprised of two subunits, one small (40S) and one large ...

A "Referral from the Doctor" Blog Article- Top 10 Reference Genes for probe-based Real-time PCR in 2009: • Acidic ...

When to use an internal Black Hole Quencher (BHQ) label in a fluorescence-quenched probe for real-time qPCR. When the ...

Biosearch Technologies will now be offering the option of salt-free primer pairs for purchase with any probe order. A ...

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