Oligo synthesis and modifications

Optimise oligo synthesis and design for effective CRISPR therapeutics

Posted on Wed, Feb 21, 2024 @ 09:41 AM

In November 2023, the UK became the first country in the world to approve a gene therapy based on CRISPR-Cas9...

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Agrigenomics

Reduce SNP deserts when genotyping to inform breeding and trait stacking

Posted on Wed, Jan 31, 2024 @ 07:58 AM

Creating a crop that is more effective at meeting the needs of farmers and end consumers is the aim of every plant...

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Molecular diagnostics Disease detection

How to choose the right competent cells for phage display

Posted on Wed, Jan 24, 2024 @ 11:42 AM

Since Humira (adalimumab) became the first approved monoclonal antibody therapy developed using phage display in 2002,...

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Agrigenomics NGS-based genotyping

How potato breeders use Flex-Seq to battle against late blight disease

Posted on Mon, Dec 18, 2023 @ 10:19 AM

Potato (Solanum tuberosum) is the world’s third most important food crop after wheat and cereal and is a staple food...

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Molecular diagnostics Genomics

Molecular marvels: choosing the most suitable reverse transcriptase

Posted on Fri, Dec 01, 2023 @ 11:02 AM

Image credit: HIV Reverse Transcriptase. RCSB Protein Data Bank. The Wellcome Collection.

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qPCR

Controlling for contamination in qPCR testing

Posted on Fri, Dec 01, 2023 @ 10:26 AM

qPCR testing is usually the method of choice when high sensitivity and specificity are required. For instance, in...
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Disease detection Nucleic acid therapeutics

Why circular RNA could be the next revolution in RNA therapeutics

Posted on Wed, Nov 22, 2023 @ 10:47 AM

While RNA-based therapeutics are taking the biotechnology world by storm following the rapid development of the...

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Oligo synthesis and modifications Nucleic acid therapeutics

Synthesizing your own oligonucleotides: FAQs

Posted on Tue, Nov 07, 2023 @ 08:30 AM

Considering bringing oligo synthesis in-house? Here are some commonly asked questions that we receive, grouped into...
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Molecular diagnostics

How to design mRNA therapeutics for scalable success

Posted on Thu, Oct 26, 2023 @ 11:09 AM

The recent Nobel Prize awarded to Katalin Karikó and Drew Weissman underlined the impact their breakthroughs in mRNA...
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Agrigenomics NGS-based genotyping

Increasing livestock breeding profitability with genomic selection

Posted on Tue, Oct 17, 2023 @ 01:23 PM

How does genomic selection increase profitability?
Livestock farmers’ and breeders’ profitability is directly related...
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Molecular diagnostics Disease detection

The rise of LAMP for rapid point-of-need testing

Posted on Thu, Sep 28, 2023 @ 02:30 PM

As the world scrambled to rapidly expand PCR testing capacity in 2020, it became increasingly clear that there was a...

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Oligo synthesis and modifications

“Click” your way towards discovery and innovation

Posted on Fri, Sep 08, 2023 @ 04:08 AM

Labelling, linking or modifying biomolecules used to be a laborious process, requiring customised complex synthetic...

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Molecular diagnostics qPCR

Minimising antibiotic dependency for treating UTIs and STIs

Posted on Tue, Aug 15, 2023 @ 04:40 AM

Antimicrobial resistance (AMR) across bacterial species is developing rapidly, compounded by the improper use of...
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Agrigenomics NGS-based genotyping

US Dept of Agriculture dives into blueberry and cranberry genotyping

Posted on Fri, Jul 28, 2023 @ 10:20 AM

Every year over 1.5 million tonnes of blueberries and over half a million tonnes of cranberries are produced. This is...

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Oligo synthesis and modifications Nucleic acid therapeutics

What’s the latest in ASO and siRNA technologies?

Posted on Fri, Jul 07, 2023 @ 10:40 AM

Over the last few decades, researchers have made impressive strides in developing methods to overcome the delivery,...
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Molecular diagnostics Nucleic acid extraction

Ditch the spin columns without compromising on nucleic acid quality

Posted on Thu, Jun 29, 2023 @ 11:41 AM

Whether you’re working with samples for PCR or sequencing, it's worth questioning what type of extraction or...
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Agrigenomics

Why genome-editing CRISPR/Cas offers hope for accelerated sustainable crop improvement in oil palm

Posted on Thu, Jun 01, 2023 @ 11:09 AM

Updated : Thu, June 1, 2023 @ 4:09 PM

Oil palm, Elaeis guineensis Jacq., is the most productive oil crop in the world1...

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Molecular diagnostics

Mastering assay scale-up: 4 tips to help avoid the most common mistakes

Posted on Thu, May 25, 2023 @ 10:19 AM

Updated : Fri, May 26, 2023 @ 10:18 AM

Designing a new assay and scaling it for commercial use takes thoughtful...

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Nucleic acid therapeutics

A knack for getting to the liver: GalNAc enables liver-targeted oligonucleotide therapeutics

Posted on Wed, May 24, 2023 @ 10:06 AM

Updated : Tue, May 9, 2023 @ 11:03 AM

When it comes to oligonucleotide therapeutics, the challenge has always been how...

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Molecular diagnostics Oligo synthesis and modifications qPCR

A way to simplify design and interpretation of your qPCR assays

Posted on Fri, May 05, 2023 @ 09:34 AM

Updated : Fri, May 5, 2023 @ 2:34 PM

How does a BHQ dye contribute to producing superior data from your assays?

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Oligo synthesis and modifications Nucleic acid therapeutics

Which controlled pore glass is right for your therapeutic application?

Posted on Fri, Mar 31, 2023 @ 10:48 AM

Updated : Mon, June 26, 2023 @ 10:24 AM

Oligonucleotide therapeutics have unlocked new treatment possibilities for rare...

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Agrigenomics PCR-based genotyping

Enhancing strawberry breeding with predictive models, marker-assisted selection and genotyping automation

Posted on Wed, Mar 08, 2023 @ 06:09 AM

Updated : Tue, May 9, 2023 @ 10:48 AM

Around 159,200 tonnes of strawberries are produced annually in Japan across 5,020...

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Oligo synthesis and modifications

5-Nitroindole – a universal base oligo modification

Posted on Thu, Feb 16, 2023 @ 09:27 AM

Updated : Tue, May 9, 2023 @ 10:51 AM

In the next edition of the “Know your oligo mod” series, we look at a universal...

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Celebrating the women of LGC 2023

Posted on Fri, Feb 10, 2023 @ 04:13 AM

Updated : Tue, May 9, 2023 @ 10:53 AM

This International Day of Women and Girls in Science (11 February) LGC Biosearch...

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Agrigenomics PCR-based genotyping

How MGB probes could solve your complex plant genome genotyping issues

Posted on Thu, Jan 26, 2023 @ 01:34 PM

Updated : Wed, March 22, 2023 @ 1:48 PM

Genotyping plants can be a complex and frustrating process

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Molecular diagnostics SARS-CoV-2 Disease detection

AMP conference 2022: Developing a 5-minute point-of-care PCR test

Posted on Wed, Jan 11, 2023 @ 08:15 AM

Updated : Tue, May 9, 2023 @ 10:57 AM

We were delighted to attend the Association for Molecular Pathology (AMP) 2022...

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Molecular diagnostics Oligo synthesis and modifications

What’s next for aptamers in diagnostics?

Posted on Thu, Nov 10, 2022 @ 07:25 AM

Updated : Tue, May 9, 2023 @ 11:01 AM

Originally developed in the early 1990s, aptamers have long been heralded as an...

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Molecular diagnostics Nucleic acid extraction

How to select an effective nucleic acid isolation method for human diagnostics?

Posted on Tue, Oct 18, 2022 @ 10:19 AM

Updated : Tue, May 9, 2023 @ 11:05 AM

Molecular testing protocols for pathogen detection and diagnosing human diseases...

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Agrigenomics PCR-based genotyping

Explore the vast applications of KASP genotyping for plant breeding programmes

Posted on Tue, Sep 20, 2022 @ 06:45 AM

Updated : Wed, March 22, 2023 @ 1:22 PM

Modern agriculture faces unprecedented challenges: increasing global...

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qPCR

Taq Polymerase: what is it and its applications

Posted on Fri, Aug 26, 2022 @ 07:58 AM

Updated : Wed, December 14, 2022 @ 1:54 PM

When the polymerase chain reaction (PCR) was first described, the Klenow...

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Oligo synthesis and modifications Nucleic acid therapeutics

Where are all the therapeutic aptamers?

Posted on Tue, Aug 09, 2022 @ 02:10 PM

Updated : Tue, August 9, 2022 @ 7:10 PM

New approaches that use aptamers as targeting agents may open the door to wider...

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Molecular diagnostics Oligo synthesis and modifications qPCR

Choosing the best qPCR probe chemistry for your assay

Posted on Thu, Jul 28, 2022 @ 10:15 AM

Updated : Tue, May 9, 2023 @ 10:40 AM

Let the application be your guide when deciding between LNA, MGB and BHQplus 

The...

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Molecular diagnostics Disease detection

Pivoting to monkeypox diagnostics

Posted on Thu, Jul 07, 2022 @ 05:38 PM

Updated : Wed, March 22, 2023 @ 1:59 PM

Since 13 May 2022, reports of monkeypox cases began to appear globally in...

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Agrigenomics PCR-based genotyping NGS-based genotyping

Genetic solutions to infectious diseases in aquaculture

Posted on Thu, Jun 30, 2022 @ 04:12 PM

Updated : Mon, April 17, 2023 @ 8:33 AM

This is the second blog in a two-part series exploring solutions for infectious...

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SARS-CoV-2 Nucleic acid extraction Disease detection

Make your diagnostic workflows more adaptable

Posted on Mon, Jun 06, 2022 @ 02:47 PM

Updated : Fri, December 16, 2022 @ 3:39 PM

Since early 2020, diagnostic laboratories have had to manage patient sample...

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Agrigenomics

Increasing resistance to aquaculture disease

Posted on Tue, Apr 19, 2022 @ 11:00 AM

Updated : Mon, April 17, 2023 @ 1:33 PM

This is the first blog in a two-part series exploring solutions for infectious...

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SARS-CoV-2

Pandemic reflections: Adapting to testing priorities

Posted on Tue, Apr 05, 2022 @ 04:55 PM

Updated : Tue, March 21, 2023 @ 3:23 PM

What’s changed for clinical labs as we enter the third year of COVID-19 testing?

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Molecular diagnostics qPCR

Optimising automated high-throughput pathogen detection workflows

Posted on Wed, Mar 30, 2022 @ 11:00 AM

Updated : Wed, March 30, 2022 @ 4:00 PM

While both centralised and decentralised molecular diagnostics (MDx) testing...

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Oligo synthesis and modifications Nucleic acid therapeutics

Overcoming manufacturing challenges associated with nucleic acid therapeutics

Posted on Thu, Mar 24, 2022 @ 06:15 PM

Updated : Tue, March 21, 2023 @ 3:46 PM

This is the second blog in a two-part series exploring how oligonucleotide...

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Agrigenomics qPCR PCR-based genotyping

Improving the sustainability of oil palm breeding programmes using marker-assisted selection

Posted on Tue, Mar 08, 2022 @ 03:00 PM

Updated : Wed, March 9, 2022 @ 1:05 AM

African oil palm (Elaeis guineensis Jacq.) is a highly productive perennial crop...

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Molecular diagnostics qPCR

Considerations for RT-qPCR in molecular point of care testing devices

Posted on Tue, Mar 01, 2022 @ 03:11 PM

Updated : Fri, April 15, 2022 @ 8:58 PM

The COVID-19 pandemic has accelerated the uptake of point of care testing...

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Oligo synthesis and modifications Nucleic acid therapeutics

Nucleic acid therapeutics for next-generation disease management

Posted on Fri, Feb 25, 2022 @ 02:47 PM

Updated : Tue, March 21, 2023 @ 3:44 PM

This is the first blog post in a two-part series exploring how oligonucleotide...

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qPCR SARS-CoV-2

Society can’t handle the caveats to each type of COVID-19 test

Posted on Fri, Feb 11, 2022 @ 04:58 PM

Updated : Fri, February 11, 2022 @ 10:58 PM

But measurement science could help steer us in a better, more informed...

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Oligo synthesis and modifications

Leveraging quenching efficiency of Black Hole Quencher dyes for PCR and beyond

Posted on Tue, Jan 25, 2022 @ 02:30 PM

Updated : Tue, January 25, 2022 @ 8:30 PM

More innovative applications for Black Hole Quencher (BHQ) dyes

In imaging...

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RNA FISH

Five ways controls can demystify your Stellaris™ RNA FISH experiment

Posted on Sun, Jan 23, 2022 @ 06:14 AM

Updated : Wed, March 22, 2023 @ 1:23 PM

Stellaris controls, who needs ‘em? We all do. Especially if it’s your first...

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Agrigenomics qPCR PCR-based genotyping

Increasing hybrid rice breeding efficiency with high-throughput genotyping

Posted on Tue, Jan 18, 2022 @ 03:03 PM

Updated : Thu, January 12, 2023 @ 5:10 PM

Rice is the primary staple for more than half the world's population.1 With...

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SARS-CoV-2

Pandemic reflections: in the face of SARS-CoV-2 variants, COVID-19 testing remains essential

Posted on Tue, Jan 11, 2022 @ 12:00 PM

Updated : Tue, January 11, 2022 @ 6:00 PM

What’s changed for clinical labs as we enter the third year of COVID-19...

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SARS-CoV-2

Pandemic reflections: unprecedented demand drives COVID-19 test developers to get creative

Posted on Tue, Dec 28, 2021 @ 09:30 AM

Updated : Tue, December 28, 2021 @ 3:30 PM

What’s changed for clinical labs as we enter the third year of COVID-19...

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Molecular diagnostics SARS-CoV-2

Technical bulletin: Omicron impact on SARS-CoV-2 mutation analysis and investigation

Posted on Thu, Dec 23, 2021 @ 11:45 AM

Updated : Wed, March 22, 2023 @ 2:01 PM

The emergence of the Omicron lineage has quickly escalated to be a variant of...

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SARS-CoV-2

Pandemic reflections: the world is short staffed

Posted on Tue, Dec 21, 2021 @ 06:52 PM

Updated : Thu, March 9, 2023 @ 5:39 PM

What’s changed for clinical labs as we enter the third year of COVID-19 testing?

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Oligo synthesis and modifications

Oligonucleotide synthesis basics: Key takeaways for post-synthesis processing

Posted on Thu, Dec 16, 2021 @ 04:39 PM

Updated : Wed, December 14, 2022 @ 4:45 PM

This is the final blog post in a three-part educational series about best...

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Molecular diagnostics SARS-CoV-2

Ensuring our diagnostic assays detect the Omicron variant

Posted on Thu, Dec 09, 2021 @ 04:24 PM

Updated : Fri, December 10, 2021 @ 2:34 AM

On 22 November 2021, The Network for Genomics Surveillance in South Africa...

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Agrigenomics Next generation sequencing (NGS) NGS-based genotyping

A targeted GBS technology for all breeding communities

Posted on Tue, Dec 07, 2021 @ 04:11 PM

Updated : Tue, December 7, 2021 @ 10:11 PM

The decisions made by molecular breeding programmes have a substantial...

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Molecular diagnostics

Extensions to the IVDR - what diagnostics manufacturers and suppliers need to know

Posted on Thu, Dec 02, 2021 @ 05:25 PM

We're excited to announce that the proposal to extend certain key provisions of the In Vitro Diagnostic Regulation...
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Molecular diagnostics SARS-CoV-2 Disease detection

Streamlining diagnostic workflows for common respiratory diseases, such as SARS-CoV-2, influenza and RSV

Posted on Tue, Nov 30, 2021 @ 04:29 PM

Updated : Tue, November 30, 2021 @ 10:29 PM

A fourth wave of COVID-19 has already emerged in many countries and a newly...

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Agrigenomics NGS-based genotyping

NGS solutions for polyploid plant breeding challenges

Posted on Tue, Nov 23, 2021 @ 09:00 AM

Updated : Fri, June 30, 2023 @ 2:19 PM

Many cultivated crops with agronomic significance, including wheat, peanut, oat,...

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Molecular diagnostics Oligo synthesis and modifications

Innovative applications for Black Hole Quencher dyes

Posted on Tue, Nov 16, 2021 @ 04:14 PM

Updated : Tue, January 25, 2022 @ 10:23 PM

This is the first blog post in a two-part series highlighting how Black Hole...

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Oligo synthesis and modifications

Oligonucleotide synthesis basics: 4 key takeaways for in-house oligo production

Posted on Tue, Nov 02, 2021 @ 11:41 AM

Updated : Wed, December 14, 2022 @ 4:43 PM

This is the second blog post in a three-part educational series about best...

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Molecular diagnostics SARS-CoV-2

Technical bulletin: SARS-CoV-2 mutation analysis and investigation

Posted on Thu, Oct 14, 2021 @ 05:01 PM

Updated : Thu, October 14, 2021 @ 10:01 PM

SARS-CoV-2 mutations and associated new variants are being reported...

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qPCR

8 qPCR amplification plot questions answered

Posted on Thu, Sep 30, 2021 @ 10:00 AM

Updated : Thu, February 3, 2022 @ 6:10 PM

When results from your qPCR assays aren’t quite what you expected, it can be...

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Molecular diagnostics qPCR SARS-CoV-2

Can COVID-19 testing be made more sustainable during prolonged uncertainty?

Posted on Mon, Sep 27, 2021 @ 02:36 PM

Updated : Thu, March 31, 2022 @ 3:24 PM

In September 2021, Delta persists as the most prevalent variant worldwide1 due...

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Molecular diagnostics

The surprising global impacts of Europe's In Vitro Diagnostic Regulation (IVDR)

Posted on Thu, Sep 16, 2021 @ 12:15 PM

Updated : Wed, September 15, 2021 @ 4:40 AM

A shortcut to understanding how to prepare for IVDR

In today’s global...

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Oligo synthesis and modifications

Oligonucleotide synthesis basics: Introduction to phosphoramidite chemistry

Posted on Tue, Sep 14, 2021 @ 02:00 PM

Updated : Wed, December 14, 2022 @ 4:43 PM

This is the first blog post in a three-part educational series about best...

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Agrigenomics PCR-based genotyping Nucleic acid extraction

4 steps to optimise sample collection for aquaculture genotyping

Posted on Tue, Sep 07, 2021 @ 02:59 PM

Updated : Tue, September 7, 2021 @ 7:59 PM

Aquaculture breeding programmes adopt genomic technologies, including...

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Molecular diagnostics SARS-CoV-2

Tips for early-stage MDx companies launching new tests during COVID-19 times

Posted on Thu, Sep 02, 2021 @ 02:00 PM

Updated : Wed, November 9, 2022 @ 8:20 PM

The COVID-19 pandemic brought tremendous change to the molecular diagnostics...

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SARS-CoV-2

Wastewater surveillance: a critical tool in pandemic management

Posted on Tue, Aug 31, 2021 @ 09:48 AM

Updated : Thu, September 29, 2022 @ 7:57 PM

As SARS-CoV-2 variants continue to threaten public health, officials are...

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SARS-CoV-2

Technical bulletin: Emerging SARS-CoV-2 mutations and their effect on the immune response

Posted on Wed, Aug 18, 2021 @ 03:45 PM

Updated : Thu, December 16, 2021 @ 6:46 PM

Emerging SARS-CoV-2 variants of concern and variants of interest are defined...

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Agrigenomics Next generation sequencing (NGS) Nucleic acid extraction

The importance of sample processing for successful plant genotyping by NGS

Posted on Thu, Aug 12, 2021 @ 06:51 PM

Updated : Thu, August 12, 2021 @ 11:51 PM

Informed plant breeding decisions help drive the field of agrigenomics...

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Agrigenomics Nucleic acid extraction

Don't underestimate the complexity of your sample composition

Posted on Wed, Aug 04, 2021 @ 04:34 PM

Updated : Wed, August 4, 2021 @ 9:34 PM

A common mistake when initiating an agrigenomics project is failing to consider...

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Agrigenomics Genomics

Selective breeding in aquaculture: advancing breeding programmes through genomics

Posted on Wed, Jun 09, 2021 @ 11:15 AM

Updated : Wed, December 14, 2022 @ 1:44 PM

The global demand for fish and fish products continues to increase as...

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Molecular diagnostics Genomics SARS-CoV-2

Genomic surveillance: 3 techniques to detect and characterise SARS-CoV-2 variants

Posted on Wed, May 19, 2021 @ 11:34 AM

Updated : Thu, March 9, 2023 @ 5:37 PM

As the global population gains greater access to vaccines for COVID-19,...

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Molecular diagnostics SARS-CoV-2

How do SARS-CoV-2 variants affect PCR assays for COVID-19 testing?

Posted on Tue, May 04, 2021 @ 11:03 AM

Updated : Thu, March 9, 2023 @ 5:34 PM

Researchers have identified several variants of SARS-CoV-2 since they sequenced...

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Agrigenomics Genomics NGS-based genotyping

Best practices for implementing targeted genotyping by sequencing

Posted on Wed, Dec 02, 2020 @ 10:53 AM

Updated : Fri, November 20, 2020 @ 5:16 PM

In breeding programmes, selections based on a single or small number of...

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Molecular diagnostics Genomics SARS-CoV-2

Building resilience into SARS-CoV-2 testing workflows: considerations for choosing an RNA isolation method

Posted on Wed, Oct 21, 2020 @ 11:00 AM

Updated : Thu, February 3, 2022 @ 4:39 PM

Clinical and diagnostic labs worldwide are still experiencing supply chain...

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Genomics PCR-based genotyping

How high-throughput genotyping automation and KASP marker libraries connect research labs with commercial breeders to accelerate crop improvement

Posted on Wed, Oct 07, 2020 @ 11:31 AM

Updated : Wed, October 7, 2020 @ 4:33 PM

“In July of 2015, I was a member of the radish genome project team. My task...

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Agrigenomics Genomics PCR-based genotyping

Employee spotlight: Meet Darshna "Dusty" Vyas

Posted on Mon, Sep 14, 2020 @ 10:15 AM

Updated : Fri, September 11, 2020 @ 9:52 PM

Darshna "Dusty" Vyas has been a Senior Scientist at LGC specialising in...

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Molecular diagnostics Genomics SARS-CoV-2

Pressing COVID-19 testing issues of today and the near future

Posted on Wed, Aug 26, 2020 @ 09:57 AM

Updated : Tue, October 6, 2020 @ 6:45 PM

Following up with the panelists from our recent COVID-19 webinar, Part 3 of 3

...

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Molecular diagnostics Genomics SARS-CoV-2

Sensitivity and accuracy in COVID-19 testing

Posted on Wed, Aug 19, 2020 @ 09:56 AM

Updated : Tue, October 6, 2020 @ 6:42 PM

Following up with the panelists from our recent COVID-19 webinar, Part 2 of 3

...

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Molecular diagnostics Genomics SARS-CoV-2

Scaling up COVID-19 viral testing

Posted on Wed, Aug 12, 2020 @ 09:47 AM

Updated : Tue, October 6, 2020 @ 6:45 PM

Following up with the panelists from our recent COVID-19 webinar, Part 1 of 3

...

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Molecular diagnostics Genomics qPCR SARS-CoV-2

Enabling a rapid response to COVID-19 by Honeywell and LGC, Biosearch Technologies

Posted on Wed, Jul 29, 2020 @ 02:40 PM

Updated : Tue, October 6, 2020 @ 6:44 PM

As countries worldwide begin to ease lockdown restrictions during the pandemic...

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Agrigenomics Genomics PCR-based genotyping

Establishment of KASP marker library for genetic diversity analysis in Brassica rapa  crops

Posted on Tue, Jul 14, 2020 @ 10:17 AM

Updated : Tue, July 14, 2020 @ 1:30 PM

Brassica  rapa crops are important sources of food, feed, and fuel in many parts...

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Molecular diagnostics Genomics qPCR SARS-CoV-2

Robust supply chains and open testing systems: How our AgBio roots meet the FDA's EUA process to enable solutions to the COVID-19 pandemic

Posted on Tue, May 19, 2020 @ 10:18 AM

Updated : Fri, December 18, 2020 @ 8:49 PM

It may seem strange that a company known for transforming the global seed...

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Molecular diagnostics Oligo synthesis and modifications Genomics SARS-CoV-2

Behind the scenes: How our oligo synthesis team contributes to the reliability of your assays

Posted on Thu, Apr 30, 2020 @ 04:13 PM

Updated : Wed, March 22, 2023 @ 1:52 PM

We’re not rejecting you, just your oligo

PCR is arguably one of the most...

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Molecular diagnostics SARS-CoV-2

When you don’t need an EUA for SARS-CoV-2 testing

Posted on Fri, Apr 10, 2020 @ 05:00 PM

Updated : Wed, November 25, 2020 @ 8:23 PM

On March 25, 2020, the US Food and Drug Administration (FDA) held the first...

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Genomics Next generation sequencing (NGS) NGS-based genotyping

New NGS service lab now open in Middleton, WI for expanded global support

Posted on Wed, Apr 01, 2020 @ 11:27 AM

Updated : Wed, April 1, 2020 @ 8:12 PM

Back in September 2018, LGC acquired Lucigen Corporation. The ISO accredited...

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Molecular diagnostics Oligo synthesis and modifications Genomics SARS-CoV-2

Addressing COVID-19 together: LGC, Biosearch Technologies and Shanghai Liferiver Biotechnology Co., Ltd.

Posted on Tue, Mar 31, 2020 @ 12:13 PM

Updated : Tue, October 6, 2020 @ 6:44 PM

In the nearly three months since the first confirmed case of COVID-19, the...

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Molecular diagnostics Genomics SARS-CoV-2

What diagnostic test makers and CLIA labs in the US need to know about Emergency Use Authorization (EUA)

Posted on Tue, Mar 24, 2020 @ 01:58 PM

Updated : Tue, March 21, 2023 @ 3:41 PM

*Since the original publication of this blog, LGC Biosearch Technologies is now...

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Molecular diagnostics Genomics SARS-CoV-2

Coronavirus outbreak: Collaboration to meet the challenge

Posted on Mon, Mar 16, 2020 @ 02:30 PM

{% video_player "embed_player" overrideable=False, type='scriptV4', hide_playlist=True, viral_sharing=False,...
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Molecular diagnostics Next generation sequencing (NGS)

Molecular diagnostics: how can NGS live up to its promises?

Posted on Wed, Jan 29, 2020 @ 11:37 AM

Updated : Tue, October 11, 2022 @ 8:43 PM

The development of new genomic sequencing techniques and bioinformatics...

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Genomics PCR-based genotyping NGS-based genotyping

Back to basics - the crucial step of sample collection

Posted on Wed, Jan 15, 2020 @ 11:37 AM

Updated : Mon, January 13, 2020 @ 5:08 PM

Best practice in sample collection for SeqSNP targeted genotyping by...

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Agrigenomics Genomics Next generation sequencing (NGS) NGS-based genotyping

Genomic selection: can it accelerate livestock breeding?

Posted on Wed, May 01, 2019 @ 10:44 AM

Updated : Wed, May 1, 2019 @ 3:59 PM

Livestock supports the livelihoods and food security of almost 1.3 billion people...

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Genomics

The women of LGC, Biosearch Technologies

Posted on Fri, Mar 29, 2019 @ 11:24 AM

Updated : Fri, March 29, 2019 @ 4:39 PM

We've heard it said for years, "TV will rot your brain". But in the case of our...

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Agrigenomics PCR-based genotyping Next generation sequencing (NGS) NGS-based genotyping

Agrigenomics: how can NGS contribute to global food security?

Posted on Wed, Mar 06, 2019 @ 10:33 AM

Updated : Fri, May 19, 2023 @ 8:53 AM

“Experience of artificial fertilisation, such as is effected with ornamental...

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Agrigenomics Next generation sequencing (NGS) NGS-based genotyping

How targeted GBS-driven genomic selection can help you get to market faster

Posted on Wed, Jan 16, 2019 @ 01:22 PM

Updated : Thu, May 25, 2023 @ 11:32 AM

Plant and animal breeding programmes often take generations to improve quality...

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Genomics NGS-based genotyping

Genomic selection: methods in crop and animal breeding

Posted on Wed, Jan 09, 2019 @ 10:48 AM

Updated : Wed, January 9, 2019 @ 5:03 PM

Genomic selection: 6 factors to consider when choosing between targeted GBS...

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Agrigenomics Next generation sequencing (NGS) NGS-based genotyping

Our hungry planet: new tools in agrigenomics are key to food security

Posted on Tue, Dec 11, 2018 @ 10:32 AM

Updated : Tue, December 11, 2018 @ 4:32 PM

Food security is a major global threat and traditional methods of plant and...

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PCR-based genotyping

Accelerating rice improvement in South Asia

Posted on Thu, Jul 26, 2018 @ 11:26 AM

Updated : Thu, July 26, 2018 @ 4:41 PM

Diversity is the spice of life and is also key to breeding rice that delivers...

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Genomics

Revolutionising cancer treatment one Array at a time

Posted on Tue, Jul 10, 2018 @ 11:05 AM

Updated : Mon, September 19, 2022 @ 2:14 PM

While the science of pharmacogenomics has been around for years, its...

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Genomics Nucleic acid extraction

Pack it up, pack it in, let me begin: A look at the future of DNA data storage

Posted on Thu, Jun 28, 2018 @ 11:13 AM

Updated : Thu, June 28, 2018 @ 4:28 PM

Imagine a time capsule the size of a shoebox that holds all the information...

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RNA FISH Genomics

Warning! Pitfalls ahead: How to avoid the most common Stellaris RNA FISH mistakes

Posted on Tue, May 29, 2018 @ 10:32 AM

Updated : Tue, May 29, 2018 @ 3:47 PM

Ever wake up in the morning just feeling like a rock star, or maybe like Francis...

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RNA FISH Genomics

Shining a light on gene expression and regulation one cell at a time

Posted on Thu, Apr 19, 2018 @ 12:51 PM

Updated : Mon, April 30, 2018 @ 1:53 PM

To truly understand complex diseases such as cancer, scientists need access to...

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Genomics

The Women of LGC

Posted on Thu, Mar 29, 2018 @ 10:45 AM

Updated : Thu, March 29, 2018 @ 4:00 PM

Ask any little girl what they want to be when they grow up and you may hear...

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RNA FISH Genomics

In case you missed it: Stellaris RNA FISH lunch-and-learn

Posted on Tue, Jan 16, 2018 @ 10:35 AM

Updated : Tue, January 16, 2018 @ 4:50 PM

Stellaris® RNA FISH (fluorescence in situ hybridization) is an RNA...

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Agrigenomics Genomics NGS-based genotyping

Tackling food crisis through cost effective, target enriched sequencing

Posted on Wed, Dec 13, 2017 @ 10:07 AM

Updated : Mon, September 19, 2022 @ 2:16 PM

With the global population predicted to reach 9 billion people within the...

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Agrigenomics Genomics PCR-based genotyping

New SNPs identified in the hunt for new genetic weapons targeting leaf rust in wheat

Posted on Tue, Nov 21, 2017 @ 11:25 AM

Updated : Wed, November 22, 2017 @ 1:44 PM

Wheat is one of the three most important crops for human and livestock feed....

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Agrigenomics Genomics PCR-based genotyping

Super-crops helping to feed Africa

Posted on Fri, Nov 03, 2017 @ 11:08 AM

Updated : Tue, July 10, 2018 @ 9:08 PM

Our world population is growing at a tremendous rate and by 2050, Africa’s...

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Genomics PCR-based genotyping Disease detection

How genotyping is aiding in the fight against malaria

Posted on Wed, Sep 20, 2017 @ 10:11 AM

Updated : Mon, September 19, 2022 @ 2:14 PM

3.2 billion people across 106 countries and territories, live in areas at...

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RNA FISH Genomics

Lunch & Learn: Stellaris RNA FISH

Posted on Thu, Jul 06, 2017 @ 10:07 AM

Updated : Thu, July 6, 2017 @ 3:22 PM

Recently LGC Genomics hosted a lunch and learn Stellaris® seminar at the Helen...

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Genomics qPCR

It’s official! Personal Health becomes first China demonstration laboratory site for LGC’s Nexar System

Posted on Wed, May 03, 2017 @ 09:05 AM

Updated : Mon, September 19, 2022 @ 2:07 PM

LGC's Genomics Division has signed a memorandum of understanding (MOU) with...

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qPCR

Digital PCR – improving reproducible molecular methods in the clinic

Posted on Thu, Apr 06, 2017 @ 10:40 AM

Updated : Thu, April 6, 2017 @ 3:40 PM

A recent study coordinated by LGC and published in the journal Analytical...

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RNA FISH Disease detection

Shining a light on how Zika virus may spread from mothers to human fetuses

Posted on Mon, Mar 06, 2017 @ 10:37 AM

Updated : Mon, March 6, 2017 @ 4:37 PM

New research has, for the first time, found evidence suggesting the molecular...

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Water – Back to Basics for Thermal Cycling

Posted on Tue, Feb 28, 2017 @ 10:13 AM

Updated : Mon, September 19, 2022 @ 2:20 PM

It’s time to forget what you know about heating your PCR plates for...

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Genomics PCR-based genotyping

Overcoming drought-intolerance in maize to feed the growing Asian population

Posted on Wed, Feb 15, 2017 @ 09:53 AM

Updated : Wed, February 15, 2017 @ 4:23 PM

Demand for maize is increasing due to an increased number of people...

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Genomics

Automate to Accelerate and Scale-up SNP-based Genotyping Workflows!

Posted on Thu, Feb 02, 2017 @ 09:14 AM

Updated : Mon, September 19, 2022 @ 2:05 PM

The advent of and ongoing improvements to next-generation sequencing...

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Genomics

Multiple Misunderstandings: Learning from Genetic Determinism

Posted on Mon, Jan 23, 2017 @ 10:12 AM

Updated : Mon, January 23, 2017 @ 4:27 PM

Nature versus nurture. It’s a tale as old as time.

When Craig Venter made the...

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Agrigenomics Genomics PCR-based genotyping NGS-based genotyping

Helping to Feed the World with Genotyping by Sequencing

Posted on Tue, Jan 17, 2017 @ 09:42 PM

Updated : Wed, January 18, 2017 @ 2:13 PM

Many areas critical to improved agricultural production require robust and...

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PCR-based genotyping

Faster, stronger, quicker: SSR to KASP will get you there

Posted on Mon, Jan 09, 2017 @ 09:05 AM

Updated : Mon, January 9, 2017 @ 3:20 PM

Screen more markers faster and bring crops with superior traits to the market...

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Genomics qPCR

Multiplex your qPCR and Walk-away

Posted on Thu, Dec 15, 2016 @ 10:17 AM

Updated : Mon, September 19, 2022 @ 2:15 PM

It seems everyone wants to do more with less, and automate the process as...

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RNA FISH Genomics

A Stellar-is Year in the Making

Posted on Wed, Dec 07, 2016 @ 10:05 AM

Updated : Mon, September 19, 2022 @ 2:12 PM 

It wouldn't be fair to close out 2016 without showcasing the stellar year...

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Genomics

Buddy Up: The Double Helix

Posted on Mon, Nov 28, 2016 @ 09:15 AM

Updated : Mon, November 28, 2016 @ 11:31 PM

The secret of life. That’s what Francis Crick and James Watson claimed they...

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Genomics

Genes, Proteins & DNA: Our Hereditary Software

Posted on Mon, Nov 21, 2016 @ 09:17 AM

Updated : Mon, November 21, 2016 @ 3:32 PM

In the early 1900s, scientists found that the function of genes was to make...

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Genomics

"X" Marks the Spot: A closer look at chromosomes

Posted on Mon, Nov 14, 2016 @ 09:28 AM

Updated : Wed, March 29, 2023 @ 10:51 AM

The strands of DNA in your cells are organized into pieces called chromosomes....

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Genomics

Excel Autocorrect Fails the Genomics Community - Are your Results Excellent or Excel-not?

Posted on Thu, Sep 08, 2016 @ 11:30 AM

Updated : Mon, September 19, 2022 @ 2:13 PM

Researchers from the Baker IDI Heart and Diabetes Institute in Melbourne,...

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qPCR

qPCR-based molecular diagnostics at the forefront of Zika surveillance

Posted on Tue, Aug 23, 2016 @ 04:00 PM

Updated : Wed, March 29, 2023 @ 11:04 AM

As the Zika virus outbreak spreads, a wave of international concern has grown,...

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Oligo synthesis and modifications

Know your oligo mod: Thio C6 linker

Posted on Thu, Jul 14, 2016 @ 04:00 PM

Updated : Wed, March 29, 2023 @ 10:55 AM

Thio C6 Linker (Thiohexyl) 

We continue our “Know Your Oligo Mod” series with...

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Agrigenomics

A Complete Ecosystem to Accelerate Breeding Programs [Infographic]

Posted on Tue, Jun 28, 2016 @ 04:00 PM

Updated : Tue, June 28, 2016 @ 9:00 PM

Modern breeding methods rely on the identification and utilization of molecular...

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Molecular diagnostics Oligo synthesis and modifications qPCR

Photoblog: Behind the scenes of oligo synthesis

Posted on Wed, May 18, 2016 @ 05:00 PM

Updated : Wed, December 14, 2022 @ 5:04 PM

OLIGO SYNTHESIS PHOTO GLIMPSE

We’ve recently captured our talented...

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qPCR

Nova is the new black

Posted on Thu, Apr 14, 2016 @ 04:00 PM

Updated : Mon, April 24, 2023 @ 8:54 AM

LGC Biosearch Technologies has developed a new qPCR probe format powered by...

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Learn about the latest developments in technologies for molecular breeding programs

Posted on Thu, Mar 31, 2016 @ 04:00 PM

Updated : Thu, March 31, 2016 @ 9:01 PM

At this year’s 24th annual Plant & Animal Genome (PAG) conference, LGC...

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RNA FISH

Imaging Stellaris Assays Part III: Creating Professional, Publication-ready Images

Posted on Thu, Mar 10, 2016 @ 04:00 PM

Updated : Wed, August 16, 2017 @ 9:15 AM

Here is the final installment of our “Imaging Stellaris Assays” blog series....

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RNA FISH

Designing Stellaris RNA FISH Probes Part I: Increasing Probe Count

Posted on Thu, Jan 14, 2016 @ 04:00 PM

Updated : Tue, September 27, 2022 @ 2:32 PM

Stellaris® RNA FISH is a novel technology that allows for the detection of...

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Oligo synthesis and modifications qPCR

Know your oligo mod: 3' Spacer C3

Posted on Thu, Oct 15, 2015 @ 04:15 PM

Updated : Wed, March 29, 2023 @ 10:54 AM

This week, we continue our Know your oligo mod blog series and we will focus...

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RNA FISH

Imaging Stellaris Assays Part II: How to Acquire Stunning Images

Posted on Thu, Sep 24, 2015 @ 04:30 PM

Updated : Wed, August 16, 2017 @ 9:13 AM

Here we continue our “Imaging Stellaris Assays” blog series. We last left off...

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RNA FISH

Runaway RNA Stays Put

Posted on Thu, Sep 17, 2015 @ 04:00 PM

Updated : Tue, March 21, 2023 @ 3:53 PM

The cleavage and polyadenylation event, the final trimming in the molecular...

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RNA FISH

Imaging Stellaris Assays Part I: Get to Know Your Microscope

Posted on Thu, Aug 27, 2015 @ 07:00 PM

Updated : Wed, August 16, 2017 @ 9:42 PM

Stellaris® FISH is an RNA detection technology performed by means of in situ...

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Oligo synthesis and modifications

The AGCT’s of DNA synthesis

Posted on Tue, Aug 11, 2015 @ 04:00 PM

Updated : Wed, March 29, 2023 @ 10:38 AM

Chemically synthesized DNA has become an indispensable tool for molecular...

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Oligo synthesis and modifications

Know your oligo mod: BHQ® (Black Hole Quencher®) non-fluorescent quenchers

Posted on Thu, Jul 23, 2015 @ 04:00 PM

Updated : Fri, January 13, 2023 @ 11:35 AM

In this instalment, we will cover the basics of LGC Biosearch Technologies’...

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RNA FISH qPCR

And the Consensus (Sequence) is...

Posted on Thu, Jun 11, 2015 @ 04:31 PM

Updated : Fri, November 13, 2015 @ 9:25 PM

Studying the expression level of RNA transcripts is often complicated by the...

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RNA FISH

Research Highlight: Bringing Vision Research into Focus

Posted on Thu, May 28, 2015 @ 04:14 PM

Updated : Tue, March 21, 2023 @ 3:37 PM

Gene expression and molecular biology research in vision and ophthalmology...

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RNA FISH

FISH-ing for Fusions: A unique approach to fusion gene mRNA & pre-mRNA detection in cancer

Posted on Fri, May 15, 2015 @ 03:00 PM

Updated : Fri, November 13, 2015 @ 10:27 PM

This past April, Biosearch attended the American Association of Cancer...

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qPCR

How Much is Your qPCR Assay Really Costing You?

Posted on Thu, Apr 02, 2015 @ 04:00 PM

Updated : Fri, November 13, 2015 @ 10:40 PM

In the setup of a qPCR experiment, one of the first decisions to make is...

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RNA FISH

The 4Cs of Stellaris® RNA FISH Buffers

Posted on Thu, Feb 26, 2015 @ 04:00 PM

Updated : Mon, November 16, 2015 @ 3:55 PM 

Buffers are often overlooked and taken for granted until the day comes when...

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Oligo synthesis and modifications

Know your oligo mod: phosphorothioate bonds

Posted on Thu, Feb 12, 2015 @ 04:00 PM

Updated : Wed, March 29, 2023 @ 10:56 AM

This post in our continuing series, “Know your oligo mod” will cover ...

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qPCR

Optimising multiplex competitive qRT-PCR in diagnostics with BHQplus probes

Posted on Thu, Jan 29, 2015 @ 04:00 PM

Updated : Mon, November 16, 2015 @ 5:30 PM

In a webinar linked below, Dr. James Willey describes a two colour...

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qPCR PCR-based genotyping

A Successful Duo for Accurate, Speedy, and Economical SNP Genotyping

Posted on Thu, Jan 08, 2015 @ 01:30 PM

Updated : Mon, September 19, 2022 @ 2:12 PM

Single Nucleotide Polymorphisms (SNPs) have been widely studied for over 15...

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Oligo synthesis and modifications

Know your oligo mod: Methylene Blue

Posted on Tue, Dec 09, 2014 @ 04:02 PM

Updated : Wed, March 29, 2023 @ 10:56 AM

The chemical synthesis of oligonucleotides allows for the incorporation of a...

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RNA FISH

Unraveling the Neural Web: Stellaris® RNA FISH for Neuroscience Research

Posted on Thu, Nov 13, 2014 @ 05:45 PM

Updated : Mon, September 19, 2022 @ 2:14 PM

Neuroscience gene expression research can come with many hurdles,...

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qPCR

Check out our new website qPCR Design Lab @ qPCRdesign.com

Posted on Thu, Oct 23, 2014 @ 04:00 PM

Updated : Tue, March 28, 2023 @ 9:02 PM

Biosearch Technologies has launched qPCRdesign.com, a microsite targeted...

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Oligo synthesis and modifications qPCR

Delivering Oligos by Nanomole Units

Posted on Wed, Oct 15, 2014 @ 01:00 PM

Updated : Tue, October 14, 2014 @ 10:21 PM

Different oligonucleotide manufacturers deliver probes and primers in a...

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Molecular diagnostics qPCR

RT-qPCR Molecular Diagnostics Assist Workers at the Forefront of Ebola Outbreak.

Posted on Thu, Sep 25, 2014 @ 01:30 PM

Updated : Mon, September 19, 2022 @ 2:13 PM

The largest recorded Ebola Virus Disease outbreak in history continues to...

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qPCR

One step too many? Simplify your qPCR protocol

Posted on Thu, Feb 27, 2014 @ 12:02 PM

Updated : Mon, September 19, 2022 @ 2:12 PM

Don’t waste time performing an extra step. Cut back on pipetting and order...

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qPCR

30 Years: The Impact of PCR

Posted on Thu, Sep 05, 2013 @ 11:29 AM

Updated : Tue, March 21, 2023 @ 3:52 PM

Do you remember when the most popular method of DNA amplification involved...

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RNA FISH qPCR

RT-qPCR and the Stellaris FISH Method

Posted on Fri, Apr 26, 2013 @ 12:32 PM

Updated : Mon, September 19, 2022 @ 2:10 PM

A "Referral from the Doctor" Blog Article-

Quantitative reverse...

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Biosearch Technologies Responds To China Influenza H7N9 Outbreak By Providing H7N9 Detection Panel

Posted on Mon, Apr 15, 2013 @ 08:00 AM

Updated : Mon, September 19, 2022 @ 2:13 PM

Biosearch Technologies, Inc. (Biosearch) announced today that the company...

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RNA FISH

Stellaris® Foundation Genes: GAPDH

Posted on Thu, Apr 11, 2013 @ 11:30 AM

Updated : Wed, October 1, 2014 @ 4:53 PM

Stellaris probe sets targeting glyceraldehyde-3-phosphate dehydrogenase...

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RNA FISH

Biosearch Technologies, UMDNJ Stellaris® Probe Alliance - NextGen Gene Expression™, SNP FISH™, and iceFISH™ in Research and Clinical Applications

Posted on Mon, Mar 18, 2013 @ 10:43 AM

Updated : Mon, September 19, 2022 @ 2:07 PM

Biosearch Technologies, Inc. (Biosearch), a leading supplier of...

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Biosearch Technologies Announces Acquisition of European Companies DNA Technology and VitraBio

Posted on Thu, Feb 21, 2013 @ 08:00 AM

Updated : Wed, October 1, 2014 @ 4:53 PM

Biosearch Technologies, Inc. (Biosearch), a leading supplier of...

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RNA FISH

Biosearch Technologies Launches Catalogued Stellaris™ RNA FISH Assays

Posted on Mon, Jun 18, 2012 @ 10:08 AM

Updated : Mon, September 19, 2022 @ 2:07 PM

Biosearch Technologies, Inc. (Biosearch), a leading supplier of...

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RNA FISH

Single molecule viral RNA analysis using Stellaris™ FISH technology

Posted on Wed, May 30, 2012 @ 03:00 PM

  Image courtesy of: http://www.cdc.gov/h1n1flu/images.htm
Updated : Mon, September 19, 2022 @ 2:13 PM

A...

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Molecular diagnostics qPCR

qPCR Probes at work: Innovative CLIA test for NSCLC staging

Posted on Tue, Mar 06, 2012 @ 01:00 PM

Updated : Wed, October 1, 2014 @ 4:51 PM

Non-squamous, Non-small cell lung cancer (NSCLC), the most common cause of...

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qPCR

Factors affecting fluorophore performance in qPCR

Posted on Wed, Jan 11, 2012 @ 11:00 AM

Updated : Fri, October 21, 2022 @ 10:24 AM

Fluorophores are molecules that can absorb light energy in a process called...

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The 'Monte Carlo' Effect in qPCR

Posted on Wed, Nov 09, 2011 @ 01:00 PM

Updated : Mon, September 19, 2022 @ 2:10 PM

A "Referral from the Doctor" Blog Article-

The mathematical model of PCR...

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qPCR

Fluorescence Quenching Mechanisms for Dual-Labeled Probes

Posted on Wed, Jun 29, 2011 @ 09:44 AM

Updated : Mon, September 19, 2022 @ 2:10 PM

A "Referral from the Doctor" Blog Article-

Fluorescent probes are used in...

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qPCR

Multiplexing with Xanthenes

Posted on Wed, Jun 08, 2011 @ 11:13 AM

Updated : Mon, September 19, 2022 @ 2:10 PM

A "Referral from the Doctor" Blog Article-

Quantitative real-time PCR...

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qPCR

qPCR troubleshooting: interpreting amplification curves and diagnosing problems

Posted on Thu, May 05, 2011 @ 12:15 PM

Updated : Thu, May 11, 2023 @ 10:06 AM

If you run quantitative real-time PCR (qPCR) assays, the chances are that...

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qPCR

Between ROX and a Hard Place

Posted on Wed, Nov 10, 2010 @ 11:12 AM

Updated : Mon, September 19, 2022 @ 2:10 PM

A "Referral from the Doctor" Blog Article-

ROX in qPCR

Quantitative...

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Molecular diagnostics

Visit Biosearch at IVD Technology's Virtual Conference and Tradeshow

Posted on Thu, Sep 23, 2010 @ 04:32 PM

Updated : Mon, September 19, 2022 @ 2:07 PM

Biosearch Technologies is proud to sponsor the first IVD Technology...

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Molecular diagnostics

PilotDx Oligos: En Route to IVD

Posted on Thu, Jul 22, 2010 @ 10:07 AM

Updated : Wed, October 1, 2014 @ 4:42 PM

It can be difficult to transition a product from research to...

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qPCR

Pipetting for qPCR

Posted on Wed, Jun 09, 2010 @ 10:41 AM

Updated : Mon, September 19, 2022 @ 2:14 PM

A "Referral from the Doctor" Blog Article-

Research trends in laboratories...

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qPCR

Killer probes for qPCR: what is a Scorpions Primer?

Posted on Wed, Mar 24, 2010 @ 10:57 AM

Updated : Thu, March 23, 2023 @ 11:57 AM

ScorpionsPrimers are dual-labeled FRET probes that combine a Molecular...

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qPCR

A light in the storm: what is a Molecular Beacon?

Posted on Wed, Mar 10, 2010 @ 12:00 PM

Updated : Mon, March 20, 2023 @ 9:54 PM

Molecular Beacons are a special type of dual-labeled oligonucleotide probe....

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qPCR

Dual-labeled BHQ probes - Performance to “dye” for

Posted on Wed, Feb 24, 2010 @ 12:20 PM

Updated : Mon, September 19, 2022 @ 2:10 PM
  A "Referral from the Doctor" Blog Article

A BHQ® probe is a dual-labeled...

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qPCR

This Year's MVP (Most Valuable Practice): Touchdown PCR

Posted on Thu, Feb 04, 2010 @ 12:39 PM

Updated : Mon, September 19, 2022 @ 2:10 PM

A "Referral from the Doctor" Blog Article-  

The aim of the Polymerase...

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qPCR

The Grand Ballet: Wine and Biotechnology

Posted on Wed, Jan 27, 2010 @ 01:15 PM

Updated : Wed, October 1, 2014 @ 4:38 PM
At the third qPCR Symposium, held November 9th -12th in Millbrae, CA, ETS...
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qPCR

Alternative to DNAse I heat inactivation

Posted on Wed, Jan 13, 2010 @ 12:04 PM

Updated : Wed, December 14, 2022 @ 4:20 PM

A "Referral from the Doctor" Blog Article-

Genomic DNA contamination has...

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qPCR

A Quick Jump Start to Multiplexing qPCR

Posted on Wed, Jan 06, 2010 @ 12:01 PM

Updated : Thu, September 22, 2022 @ 5:16 PM
By now, you've no doubt read about the reductions in error, cost and time...
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qPCR

Slope Efficiency Equals Manageable and Corrected PCR

Posted on Wed, Dec 09, 2009 @ 02:01 PM

Updated : Mon, September 19, 2022 @ 2:10 PM

A "Referral from the Doctor" Blog Article-  

ε = m.c.2 (shall I explain?...

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qPCR

Bringing Back a Champion: Competitive Quantitative Real-time RT-PCR

Posted on Wed, Nov 18, 2009 @ 10:08 AM

Updated : Mon, September 19, 2022 @ 2:10 PM

A "Referral from the Doctor" Blog Article-

Competitive qRT-PCR has become...

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Oligo synthesis and modifications qPCR

The New Favorite Reference Gene: 36B4, a.k.a. RPLP0

Posted on Wed, Oct 14, 2009 @ 10:06 AM

Updated : Mon, September 19, 2022 @ 2:10 PM

A "Referral from the Doctor" Blog Article-

Ribosomes are comprised of two...
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qPCR

What Genes are Hot, What Genes are Not

Posted on Wed, Oct 07, 2009 @ 04:41 PM

Updated : Mon, September 19, 2022 @ 2:10 PM 

A "Referral from the Doctor" Blog Article-

 Top 10 Reference Genes for...

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Oligo synthesis and modifications qPCR

Labeling oligonucleotides with internal BHQ dyes

Posted on Tue, Sep 29, 2009 @ 10:16 AM

Updated : Fri, January 13, 2023 @ 11:38 AM

When to use an internal Black Hole Quencher (BHQ) label in a...

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Oligo synthesis and modifications qPCR

Salt-Free Primer Pair Option Now Available

Posted on Tue, Sep 22, 2009 @ 10:08 AM

Updated : Mon, September 19, 2022 @ 2:12 PM
Biosearch Technologies will now be offering the option of salt-free...
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Molecular diagnostics Disease detection

How to choose the right competent cells for phage display

Since Humira (adalimumab) became the first approved monoclonal antibody therapy developed using phage display in 2002, it has sold more than any other drug in...

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Molecular diagnostics Genomics

Molecular marvels: choosing the most suitable reverse transcriptase

Image credit: HIV Reverse Transcriptase. RCSB Protein Data Bank. The Wellcome Collection.

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Disease detection Nucleic acid therapeutics

Why circular RNA could be the next revolution in RNA therapeutics

While RNA-based therapeutics are taking the biotechnology world by storm following the rapid development of the COVID-19 vaccines, the next generation of...

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Oligo synthesis and modifications Nucleic acid therapeutics

Synthesizing your own oligonucleotides: FAQs

Considering bringing oligo synthesis in-house? Here are some commonly asked questions that we receive, grouped into four sections. You can jump to a section...
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Molecular diagnostics

How to design mRNA therapeutics for scalable success

The recent Nobel Prize awarded to Katalin Karikó and Drew Weissman underlined the impact their breakthroughs in mRNA technology had in combating COVID-19....
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Molecular diagnostics Disease detection

The rise of LAMP for rapid point-of-need testing

As the world scrambled to rapidly expand PCR testing capacity in 2020, it became increasingly clear that there was a need for cheaper, simpler, quicker...

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Molecular diagnostics qPCR

Minimising antibiotic dependency for treating UTIs and STIs

Antimicrobial resistance (AMR) across bacterial species is developing rapidly, compounded by the improper use of antimicrobial agents that accelerates the...
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Oligo synthesis and modifications Nucleic acid therapeutics

What’s the latest in ASO and siRNA technologies?

Over the last few decades, researchers have made impressive strides in developing methods to overcome the delivery, stability, and specificity challenges of...
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Molecular diagnostics Nucleic acid extraction

Ditch the spin columns without compromising on nucleic acid quality

Whether you’re working with samples for PCR or sequencing, it's worth questioning what type of extraction or purification method would work well with your...
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Molecular diagnostics

Mastering assay scale-up: 4 tips to help avoid the most common mistakes

Updated : Fri, May 26, 2023 @ 10:18 AM

Designing a new assay and scaling it for commercial use takes thoughtful planning, foresight, and engagement with...

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Nucleic acid therapeutics

A knack for getting to the liver: GalNAc enables liver-targeted oligonucleotide therapeutics

Updated : Tue, May 9, 2023 @ 11:03 AM

When it comes to oligonucleotide therapeutics, the challenge has always been how to deliver an intact oligo to the right...

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Molecular diagnostics Oligo synthesis and modifications qPCR General science

A way to simplify design and interpretation of your qPCR assays

Updated : Fri, May 5, 2023 @ 2:34 PM

How does a BHQ dye contribute to producing superior data from your assays?

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Oligo synthesis and modifications Nucleic acid therapeutics

Which controlled pore glass is right for your therapeutic application?

Updated : Mon, June 26, 2023 @ 10:24 AM

Oligonucleotide therapeutics have unlocked new treatment possibilities for rare and fatal diseases often associated...

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Molecular diagnostics SARS-CoV-2 Disease detection

AMP conference 2022: Developing a 5-minute point-of-care PCR test

Updated : Tue, May 9, 2023 @ 10:57 AM

We were delighted to attend the Association for Molecular Pathology (AMP) 2022 annual meeting, held in Phoenix, Arizona...

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Molecular diagnostics Oligo synthesis and modifications

What’s next for aptamers in diagnostics?

Updated : Tue, May 9, 2023 @ 11:01 AM

Originally developed in the early 1990s, aptamers have long been heralded as an antibody alternative for detection...

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Molecular diagnostics Nucleic acid extraction General science

How to select an effective nucleic acid isolation method for human diagnostics?

Updated : Tue, May 9, 2023 @ 11:05 AM

Molecular testing protocols for pathogen detection and diagnosing human diseases require reliable and high-quality...

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Oligo synthesis and modifications Nucleic acid therapeutics General science

Where are all the therapeutic aptamers?

Updated : Tue, August 9, 2022 @ 7:10 PM

New approaches that use aptamers as targeting agents may open the door to wider clinical use in the future

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Molecular diagnostics Oligo synthesis and modifications qPCR General science

Choosing the best qPCR probe chemistry for your assay

Updated : Tue, May 9, 2023 @ 10:40 AM

Let the application be your guide when deciding between LNA, MGB and BHQplus 

The many different chemistries available...

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Molecular diagnostics Disease detection

Pivoting to monkeypox diagnostics

Updated : Wed, March 22, 2023 @ 1:59 PM

Since 13 May 2022, reports of monkeypox cases began to appear globally in regions not endemic to the monkeypox virus.1...

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SARS-CoV-2 Nucleic acid extraction Disease detection General science

Make your diagnostic workflows more adaptable

Updated : Fri, December 16, 2022 @ 3:39 PM

Since early 2020, diagnostic laboratories have had to manage patient sample quantities being in a state of flux....

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SARS-CoV-2

Pandemic reflections: Adapting to testing priorities

Updated : Tue, March 21, 2023 @ 3:23 PM

What’s changed for clinical labs as we enter the third year of COVID-19 testing?

COVID-19, the illness caused by...

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Molecular diagnostics qPCR General science

Optimising automated high-throughput pathogen detection workflows

Updated : Wed, March 30, 2022 @ 4:00 PM

While both centralised and decentralised molecular diagnostics (MDx) testing models play an important role in patient...

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Oligo synthesis and modifications Nucleic acid therapeutics

Overcoming manufacturing challenges associated with nucleic acid therapeutics

Updated : Tue, March 21, 2023 @ 3:46 PM

This is the second blog in a two-part series exploring how oligonucleotide modifications can support the advancement of...

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Molecular diagnostics qPCR General science

Considerations for RT-qPCR in molecular point of care testing devices

Updated : Fri, April 15, 2022 @ 8:58 PM

The COVID-19 pandemic has accelerated the uptake of point of care testing (POCT), with simple, user-administered tests...

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Oligo synthesis and modifications Nucleic acid therapeutics

Nucleic acid therapeutics for next-generation disease management

Updated : Tue, March 21, 2023 @ 3:44 PM

This is the first blog post in a two-part series exploring how oligonucleotide modifications can support the...

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qPCR SARS-CoV-2 General science

Society can’t handle the caveats to each type of COVID-19 test

Updated : Fri, February 11, 2022 @ 10:58 PM

But measurement science could help steer us in a better, more informed direction

COVID-19 tests can indicate the...

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SARS-CoV-2

Pandemic reflections: in the face of SARS-CoV-2 variants, COVID-19 testing remains essential

Updated : Tue, January 11, 2022 @ 6:00 PM

What’s changed for clinical labs as we enter the third year of COVID-19 testing?

COVID-19, the illness caused by...

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SARS-CoV-2

Pandemic reflections: unprecedented demand drives COVID-19 test developers to get creative

Updated : Tue, December 28, 2021 @ 3:30 PM

What’s changed for clinical labs as we enter the third year of COVID-19 testing?

COVID-19, the illness caused by...

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Molecular diagnostics SARS-CoV-2

Technical bulletin: Omicron impact on SARS-CoV-2 mutation analysis and investigation

Updated : Wed, March 22, 2023 @ 2:01 PM

The emergence of the Omicron lineage has quickly escalated to be a variant of concern by the World Health Organization -

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SARS-CoV-2

Pandemic reflections: the world is short staffed

Updated : Thu, March 9, 2023 @ 5:39 PM

What’s changed for clinical labs as we enter the third year of COVID-19 testing?

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Molecular diagnostics SARS-CoV-2

Ensuring our diagnostic assays detect the Omicron variant

Updated : Fri, December 10, 2021 @ 2:34 AM

On 22 November 2021, The Network for Genomics Surveillance in South Africa detected a new SARS-CoV-2 variant, named...

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Molecular diagnostics

Extensions to the IVDR - what diagnostics manufacturers and suppliers need to know

We're excited to announce that the proposal to extend certain key provisions of the In Vitro Diagnostic Regulation (IVDR) (EU) 2017/746 has been adopted...
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Molecular diagnostics SARS-CoV-2 Disease detection

Streamlining diagnostic workflows for common respiratory diseases, such as SARS-CoV-2, influenza and RSV

Updated : Tue, November 30, 2021 @ 10:29 PM

A fourth wave of COVID-19 has already emerged in many countries and a newly classified variant of concern, Omicron...

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Molecular diagnostics Oligo synthesis and modifications

Innovative applications for Black Hole Quencher dyes

Updated : Tue, January 25, 2022 @ 10:23 PM

This is the first blog post in a two-part series highlighting how Black Hole Quencher™ dyes can be incorporated into...

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Molecular diagnostics SARS-CoV-2

Technical bulletin: SARS-CoV-2 mutation analysis and investigation

Updated : Thu, October 14, 2021 @ 10:01 PM

SARS-CoV-2 mutations and associated new variants are being reported regularly in the media and scientific...

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Molecular diagnostics qPCR SARS-CoV-2 General science

Can COVID-19 testing be made more sustainable during prolonged uncertainty?

Updated : Thu, March 31, 2022 @ 3:24 PM

In September 2021, Delta persists as the most prevalent variant worldwide1 due to its high infectivity, causing surges...

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Molecular diagnostics

The surprising global impacts of Europe's In Vitro Diagnostic Regulation (IVDR)

Updated : Wed, September 15, 2021 @ 4:40 AM

A shortcut to understanding how to prepare for IVDR

In today’s global environment, even small regulatory changes in...

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Molecular diagnostics SARS-CoV-2

Tips for early-stage MDx companies launching new tests during COVID-19 times

Updated : Wed, November 9, 2022 @ 8:20 PM

The COVID-19 pandemic brought tremendous change to the molecular diagnostics (MDx) industry, delivering opportunities...

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SARS-CoV-2

Wastewater surveillance: a critical tool in pandemic management

Updated : Thu, September 29, 2022 @ 7:57 PM

As SARS-CoV-2 variants continue to threaten public health, officials are looking beyond clinical tests to track...

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SARS-CoV-2

Technical bulletin: Emerging SARS-CoV-2 mutations and their effect on the immune response

Updated : Thu, December 16, 2021 @ 6:46 PM

Emerging SARS-CoV-2 variants of concern and variants of interest are defined by agencies such as the World Health...

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Molecular diagnostics Genomics SARS-CoV-2 General science

Genomic surveillance: 3 techniques to detect and characterise SARS-CoV-2 variants

Updated : Thu, March 9, 2023 @ 5:37 PM

As the global population gains greater access to vaccines for COVID-19, scientists and health officials continue to...

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Molecular diagnostics SARS-CoV-2

How do SARS-CoV-2 variants affect PCR assays for COVID-19 testing?

Updated : Thu, March 9, 2023 @ 5:34 PM

Researchers have identified several variants of SARS-CoV-2 since they sequenced the original viral strain responsible...

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Molecular diagnostics Genomics SARS-CoV-2 General science

Building resilience into SARS-CoV-2 testing workflows: considerations for choosing an RNA isolation method

Updated : Thu, February 3, 2022 @ 4:39 PM

Clinical and diagnostic labs worldwide are still experiencing supply chain challenges with their SARS-CoV-2 testing...

Read more

Molecular diagnostics Genomics SARS-CoV-2

Pressing COVID-19 testing issues of today and the near future

Updated : Tue, October 6, 2020 @ 6:45 PM

Following up with the panelists from our recent COVID-19 webinar, Part 3 of 3

In the previous two blog posts in this...

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Molecular diagnostics Genomics SARS-CoV-2

Sensitivity and accuracy in COVID-19 testing

Updated : Tue, October 6, 2020 @ 6:42 PM

Following up with the panelists from our recent COVID-19 webinar, Part 2 of 3

In the face of a rapidly evolving...

Read more

Molecular diagnostics Genomics SARS-CoV-2

Scaling up COVID-19 viral testing

Updated : Tue, October 6, 2020 @ 6:45 PM

Following up with the panelists from our recent COVID-19 webinar, Part 1 of 3

The COVID-19 pandemic has presented...

Read more

Molecular diagnostics Genomics qPCR SARS-CoV-2

Enabling a rapid response to COVID-19 by Honeywell and LGC, Biosearch Technologies

Updated : Tue, October 6, 2020 @ 6:44 PM

As countries worldwide begin to ease lockdown restrictions during the pandemic and prepare to return to “normal”...

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Molecular diagnostics Genomics qPCR SARS-CoV-2

Robust supply chains and open testing systems: How our AgBio roots meet the FDA's EUA process to enable solutions to the COVID-19 pandemic

Updated : Fri, December 18, 2020 @ 8:49 PM

It may seem strange that a company known for transforming the global seed breeding industry is uniquely positioned...

Read more

Molecular diagnostics Oligo synthesis and modifications Genomics SARS-CoV-2 General science

Behind the scenes: How our oligo synthesis team contributes to the reliability of your assays

Updated : Wed, March 22, 2023 @ 1:52 PM

We’re not rejecting you, just your oligo

PCR is arguably one of the most enabling technologies of modern molecular...

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Molecular diagnostics SARS-CoV-2

When you don’t need an EUA for SARS-CoV-2 testing

Updated : Wed, November 25, 2020 @ 8:23 PM

On March 25, 2020, the US Food and Drug Administration (FDA) held the first of a series of virtual town halls they...

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Molecular diagnostics Oligo synthesis and modifications Genomics SARS-CoV-2

Addressing COVID-19 together: LGC, Biosearch Technologies and Shanghai Liferiver Biotechnology Co., Ltd.

Updated : Tue, October 6, 2020 @ 6:44 PM

In the nearly three months since the first confirmed case of COVID-19, the outbreak has become a global crisis, with...

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Molecular diagnostics Genomics SARS-CoV-2 General science

What diagnostic test makers and CLIA labs in the US need to know about Emergency Use Authorization (EUA)

Updated : Tue, March 21, 2023 @ 3:41 PM

*Since the original publication of this blog, LGC Biosearch Technologies is now the only acceptable commercial supplier...

Read more

Molecular diagnostics Genomics SARS-CoV-2

Coronavirus outbreak: Collaboration to meet the challenge

{% video_player "embed_player" overrideable=False, type='scriptV4', hide_playlist=True, viral_sharing=False, embed_button=False, autoplay=False,...
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Molecular diagnostics Next generation sequencing (NGS)

Molecular diagnostics: how can NGS live up to its promises?

Updated : Tue, October 11, 2022 @ 8:43 PM

The development of new genomic sequencing techniques and bioinformatics analysis in the last decade has led to...

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Genomics PCR-based genotyping Disease detection General science

How genotyping is aiding in the fight against malaria

Updated : Mon, September 19, 2022 @ 2:14 PM

3.2 billion people across 106 countries and territories, live in areas at risk of malaria transmission. The serious...

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RNA FISH Disease detection General science

Shining a light on how Zika virus may spread from mothers to human fetuses

Updated : Mon, March 6, 2017 @ 4:37 PM

New research has, for the first time, found evidence suggesting the molecular epidemiology of how the Zika virus spreads...

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Molecular diagnostics Oligo synthesis and modifications qPCR General science

Photoblog: Behind the scenes of oligo synthesis

Updated : Wed, December 14, 2022 @ 5:04 PM

OLIGO SYNTHESIS PHOTO GLIMPSE

We’ve recently captured our talented manufacturing teams hard at work building...

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Molecular diagnostics qPCR General science

RT-qPCR Molecular Diagnostics Assist Workers at the Forefront of Ebola Outbreak.

Updated : Mon, September 19, 2022 @ 2:13 PM

The largest recorded Ebola Virus Disease outbreak in history continues to devastate the West African region. This...

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Molecular diagnostics qPCR General science

qPCR Probes at work: Innovative CLIA test for NSCLC staging

Updated : Wed, October 1, 2014 @ 4:51 PM

Non-squamous, Non-small cell lung cancer (NSCLC), the most common cause of death in the US and globally, has recently...

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Molecular diagnostics

Visit Biosearch at IVD Technology's Virtual Conference and Tradeshow

Updated : Mon, September 19, 2022 @ 2:07 PM

Biosearch Technologies is proud to sponsor the first IVD Technology Virtual Conference and Tradeshow. This free...

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Molecular diagnostics

PilotDx Oligos: En Route to IVD

Updated : Wed, October 1, 2014 @ 4:42 PM

It can be difficult to transition a product from research to commercialization. It’s simply not feasible to conduct...

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Agrigenomics

Reduce SNP deserts when genotyping to inform breeding and trait stacking

Creating a crop that is more effective at meeting the needs of farmers and end consumers is the aim of every plant breeder. Using a targeted genotyping by...

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Agrigenomics NGS-based genotyping

How potato breeders use Flex-Seq to battle against late blight disease

Potato (Solanum tuberosum) is the world’s third most important food crop after wheat and cereal and is a staple food for over 1.3 billion people. The overall...

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Agrigenomics NGS-based genotyping

Increasing livestock breeding profitability with genomic selection

How does genomic selection increase profitability?
Livestock farmers’ and breeders’ profitability is directly related to the quality of their stock. But this...
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Agrigenomics NGS-based genotyping

US Dept of Agriculture dives into blueberry and cranberry genotyping

Every year over 1.5 million tonnes of blueberries and over half a million tonnes of cranberries are produced. This is expected to rise significantly over the...

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Agrigenomics

Why genome-editing CRISPR/Cas offers hope for accelerated sustainable crop improvement in oil palm

Updated : Thu, June 1, 2023 @ 4:09 PM

Oil palm, Elaeis guineensis Jacq., is the most productive oil crop in the world1 supplying around 40% of all globally...

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Agrigenomics PCR-based genotyping

Enhancing strawberry breeding with predictive models, marker-assisted selection and genotyping automation

Updated : Tue, May 9, 2023 @ 10:48 AM

Around 159,200 tonnes of strawberries are produced annually in Japan across 5,020 ha in various regions around the...

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Agrigenomics PCR-based genotyping

How MGB probes could solve your complex plant genome genotyping issues

Updated : Wed, March 22, 2023 @ 1:48 PM

Genotyping plants can be a complex and frustrating process

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Agrigenomics PCR-based genotyping

Explore the vast applications of KASP genotyping for plant breeding programmes

Updated : Wed, March 22, 2023 @ 1:22 PM

Modern agriculture faces unprecedented challenges: increasing global temperatures, water scarcity, less arable land to...

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Agrigenomics PCR-based genotyping NGS-based genotyping

Genetic solutions to infectious diseases in aquaculture

Updated : Mon, April 17, 2023 @ 8:33 AM

This is the second blog in a two-part series exploring solutions for infectious diseases in aquaculture. In the first...

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Agrigenomics

Increasing resistance to aquaculture disease

Updated : Mon, April 17, 2023 @ 1:33 PM

This is the first blog in a two-part series exploring solutions for infectious diseases in aquaculture. This blog post...

Read more

Agrigenomics qPCR PCR-based genotyping General science

Improving the sustainability of oil palm breeding programmes using marker-assisted selection

Updated : Wed, March 9, 2022 @ 1:05 AM

African oil palm (Elaeis guineensis Jacq.) is a highly productive perennial crop that is used widely in food, medicines,...

Read more

Agrigenomics qPCR PCR-based genotyping

Increasing hybrid rice breeding efficiency with high-throughput genotyping

Updated : Thu, January 12, 2023 @ 5:10 PM

Rice is the primary staple for more than half the world's population.1 With so many people relying on the crop for...

Read more

Agrigenomics Next generation sequencing (NGS) NGS-based genotyping

A targeted GBS technology for all breeding communities

Updated : Tue, December 7, 2021 @ 10:11 PM

The decisions made by molecular breeding programmes have a substantial impact on the world around us, from...

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Agrigenomics NGS-based genotyping

NGS solutions for polyploid plant breeding challenges

Updated : Fri, June 30, 2023 @ 2:19 PM

Many cultivated crops with agronomic significance, including wheat, peanut, oat, banana, potato, coffee, blueberry and...

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Agrigenomics PCR-based genotyping Nucleic acid extraction

4 steps to optimise sample collection for aquaculture genotyping

Updated : Tue, September 7, 2021 @ 7:59 PM

Aquaculture breeding programmes adopt genomic technologies, including genotyping, to increase genetic gain for...

Read more

Agrigenomics Next generation sequencing (NGS) Nucleic acid extraction

The importance of sample processing for successful plant genotyping by NGS

Updated : Thu, August 12, 2021 @ 11:51 PM

Informed plant breeding decisions help drive the field of agrigenomics towards ever-increasing agricultural...

Read more

Agrigenomics Nucleic acid extraction

Don't underestimate the complexity of your sample composition

Updated : Wed, August 4, 2021 @ 9:34 PM

A common mistake when initiating an agrigenomics project is failing to consider specific sample composition before...

Read more

Agrigenomics Genomics General science

Selective breeding in aquaculture: advancing breeding programmes through genomics

Updated : Wed, December 14, 2022 @ 1:44 PM

The global demand for fish and fish products continues to increase as consumers focus on health-conscious ways to...

Read more

Agrigenomics Genomics NGS-based genotyping

Best practices for implementing targeted genotyping by sequencing

Updated : Fri, November 20, 2020 @ 5:16 PM

In breeding programmes, selections based on a single or small number of markers to target traits in marker assisted...

Read more

Genomics PCR-based genotyping

How high-throughput genotyping automation and KASP marker libraries connect research labs with commercial breeders to accelerate crop improvement

Updated : Wed, October 7, 2020 @ 4:33 PM

“In July of 2015, I was a member of the radish genome project team. My task was to examine genetic diversity of radish...

Read more

Agrigenomics Genomics PCR-based genotyping

Employee spotlight: Meet Darshna "Dusty" Vyas

Updated : Fri, September 11, 2020 @ 9:52 PM

Darshna "Dusty" Vyas has been a Senior Scientist at LGC specialising in plant genetics for the past 8 years Her...

Read more

Agrigenomics Genomics PCR-based genotyping

Establishment of KASP marker library for genetic diversity analysis in Brassica rapa  crops

Updated : Tue, July 14, 2020 @ 1:30 PM

Brassica  rapa crops are important sources of food, feed, and fuel in many parts of the world and provide a unique...

Read more

Genomics Next generation sequencing (NGS) NGS-based genotyping

New NGS service lab now open in Middleton, WI for expanded global support

Updated : Wed, April 1, 2020 @ 8:12 PM

Back in September 2018, LGC acquired Lucigen Corporation. The ISO accredited site is based in Middleton, Wisconsin and...

Read more

Genomics PCR-based genotyping NGS-based genotyping

Back to basics - the crucial step of sample collection

Updated : Mon, January 13, 2020 @ 5:08 PM

Best practice in sample collection for SeqSNP targeted genotyping by sequencing projects

When good goes in, great...

Read more

Agrigenomics Genomics Next generation sequencing (NGS) NGS-based genotyping

Genomic selection: can it accelerate livestock breeding?

Updated : Wed, May 1, 2019 @ 3:59 PM

Livestock supports the livelihoods and food security of almost 1.3 billion people worldwide, contributing 40% of the...

Read more

Agrigenomics PCR-based genotyping Next generation sequencing (NGS) NGS-based genotyping

Agrigenomics: how can NGS contribute to global food security?

Updated : Fri, May 19, 2023 @ 8:53 AM

“Experience of artificial fertilisation, such as is effected with ornamental plants in order to obtain new variations in...

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Agrigenomics Next generation sequencing (NGS) NGS-based genotyping

How targeted GBS-driven genomic selection can help you get to market faster

Updated : Thu, May 25, 2023 @ 11:32 AM

Plant and animal breeding programmes often take generations to improve quality and yield but using a genotyping protocol...

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Genomics NGS-based genotyping

Genomic selection: methods in crop and animal breeding

Updated : Wed, January 9, 2019 @ 5:03 PM

Genomic selection: 6 factors to consider when choosing between targeted GBS and microarrays

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Agrigenomics Next generation sequencing (NGS) NGS-based genotyping

Our hungry planet: new tools in agrigenomics are key to food security

Updated : Tue, December 11, 2018 @ 4:32 PM

Food security is a major global threat and traditional methods of plant and animal breeding will not be sufficient...

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PCR-based genotyping

Accelerating rice improvement in South Asia

Updated : Thu, July 26, 2018 @ 4:41 PM

Diversity is the spice of life and is also key to breeding rice that delivers increased yields. Rice is a crucial staple...

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Agrigenomics Genomics NGS-based genotyping General science

Tackling food crisis through cost effective, target enriched sequencing

Updated : Mon, September 19, 2022 @ 2:16 PM

With the global population predicted to reach 9 billion people within the next 35 years, we will need to double the...

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Agrigenomics Genomics PCR-based genotyping

New SNPs identified in the hunt for new genetic weapons targeting leaf rust in wheat

Updated : Wed, November 22, 2017 @ 1:44 PM

Wheat is one of the three most important crops for human and livestock feed. With an ever-increasing global...

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Agrigenomics Genomics PCR-based genotyping

Super-crops helping to feed Africa

Updated : Tue, July 10, 2018 @ 9:08 PM

Our world population is growing at a tremendous rate and by 2050, Africa’s population alone is set to hit over 2.5...

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Genomics PCR-based genotyping Disease detection General science

How genotyping is aiding in the fight against malaria

Updated : Mon, September 19, 2022 @ 2:14 PM

3.2 billion people across 106 countries and territories, live in areas at risk of malaria transmission. The serious...

Read more

Genomics PCR-based genotyping General science

Overcoming drought-intolerance in maize to feed the growing Asian population

Updated : Wed, February 15, 2017 @ 4:23 PM

Demand for maize is increasing due to an increased number of people transitioning to meat-based diets driving demand...

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Agrigenomics Genomics PCR-based genotyping NGS-based genotyping General science

Helping to Feed the World with Genotyping by Sequencing

Updated : Wed, January 18, 2017 @ 2:13 PM

Many areas critical to improved agricultural production require robust and scalable genotyping platforms to enable...

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PCR-based genotyping

Faster, stronger, quicker: SSR to KASP will get you there

Updated : Mon, January 9, 2017 @ 3:20 PM

Screen more markers faster and bring crops with superior traits to the market quicker.

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Agrigenomics

A Complete Ecosystem to Accelerate Breeding Programs [Infographic]

Updated : Tue, June 28, 2016 @ 9:00 PM

Modern breeding methods rely on the identification and utilization of molecular markers associated with traits...

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qPCR PCR-based genotyping General science

A Successful Duo for Accurate, Speedy, and Economical SNP Genotyping

Updated : Mon, September 19, 2022 @ 2:12 PM

Single Nucleotide Polymorphisms (SNPs) have been widely studied for over 15 years, and have applications in...

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Oligo synthesis and modifications

Optimise oligo synthesis and design for effective CRISPR therapeutics

In November 2023, the UK became the first country in the world to approve a gene therapy based on CRISPR-Cas9 technology. This Nobel prize-winning technique...

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Molecular diagnostics Genomics

Molecular marvels: choosing the most suitable reverse transcriptase

Image credit: HIV Reverse Transcriptase. RCSB Protein Data Bank. The Wellcome Collection.

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qPCR General science

Controlling for contamination in qPCR testing

qPCR testing is usually the method of choice when high sensitivity and specificity are required. For instance, in diagnostic and forensic applications, qPCR...
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Oligo synthesis and modifications Nucleic acid therapeutics

Synthesizing your own oligonucleotides: FAQs

Considering bringing oligo synthesis in-house? Here are some commonly asked questions that we receive, grouped into four sections. You can jump to a section...
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Oligo synthesis and modifications General science

“Click” your way towards discovery and innovation

Labelling, linking or modifying biomolecules used to be a laborious process, requiring customised complex synthetic pathways that yield little product....

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Molecular diagnostics qPCR

Minimising antibiotic dependency for treating UTIs and STIs

Antimicrobial resistance (AMR) across bacterial species is developing rapidly, compounded by the improper use of antimicrobial agents that accelerates the...
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Oligo synthesis and modifications Nucleic acid therapeutics

What’s the latest in ASO and siRNA technologies?

Over the last few decades, researchers have made impressive strides in developing methods to overcome the delivery, stability, and specificity challenges of...
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Molecular diagnostics Nucleic acid extraction

Ditch the spin columns without compromising on nucleic acid quality

Whether you’re working with samples for PCR or sequencing, it's worth questioning what type of extraction or purification method would work well with your...
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Molecular diagnostics Oligo synthesis and modifications qPCR General science

A way to simplify design and interpretation of your qPCR assays

Updated : Fri, May 5, 2023 @ 2:34 PM

How does a BHQ dye contribute to producing superior data from your assays?

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Oligo synthesis and modifications Nucleic acid therapeutics

Which controlled pore glass is right for your therapeutic application?

Updated : Mon, June 26, 2023 @ 10:24 AM

Oligonucleotide therapeutics have unlocked new treatment possibilities for rare and fatal diseases often associated...

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Oligo synthesis and modifications General science

5-Nitroindole – a universal base oligo modification

Updated : Tue, May 9, 2023 @ 10:51 AM

In the next edition of the “Know your oligo mod” series, we look at a universal base analogue for oligonucleotide...

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Molecular diagnostics Oligo synthesis and modifications

What’s next for aptamers in diagnostics?

Updated : Tue, May 9, 2023 @ 11:01 AM

Originally developed in the early 1990s, aptamers have long been heralded as an antibody alternative for detection...

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Molecular diagnostics Nucleic acid extraction General science

How to select an effective nucleic acid isolation method for human diagnostics?

Updated : Tue, May 9, 2023 @ 11:05 AM

Molecular testing protocols for pathogen detection and diagnosing human diseases require reliable and high-quality...

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qPCR General science

Taq Polymerase: what is it and its applications

Updated : Wed, December 14, 2022 @ 1:54 PM

When the polymerase chain reaction (PCR) was first described, the Klenow fragment of Escherichia coli DNA...

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Oligo synthesis and modifications Nucleic acid therapeutics General science

Where are all the therapeutic aptamers?

Updated : Tue, August 9, 2022 @ 7:10 PM

New approaches that use aptamers as targeting agents may open the door to wider clinical use in the future

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Molecular diagnostics Oligo synthesis and modifications qPCR General science

Choosing the best qPCR probe chemistry for your assay

Updated : Tue, May 9, 2023 @ 10:40 AM

Let the application be your guide when deciding between LNA, MGB and BHQplus 

The many different chemistries available...

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SARS-CoV-2 Nucleic acid extraction Disease detection General science

Make your diagnostic workflows more adaptable

Updated : Fri, December 16, 2022 @ 3:39 PM

Since early 2020, diagnostic laboratories have had to manage patient sample quantities being in a state of flux....

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Molecular diagnostics qPCR General science

Optimising automated high-throughput pathogen detection workflows

Updated : Wed, March 30, 2022 @ 4:00 PM

While both centralised and decentralised molecular diagnostics (MDx) testing models play an important role in patient...

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Oligo synthesis and modifications Nucleic acid therapeutics

Overcoming manufacturing challenges associated with nucleic acid therapeutics

Updated : Tue, March 21, 2023 @ 3:46 PM

This is the second blog in a two-part series exploring how oligonucleotide modifications can support the advancement of...

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Agrigenomics qPCR PCR-based genotyping General science

Improving the sustainability of oil palm breeding programmes using marker-assisted selection

Updated : Wed, March 9, 2022 @ 1:05 AM

African oil palm (Elaeis guineensis Jacq.) is a highly productive perennial crop that is used widely in food, medicines,...

Read more

Molecular diagnostics qPCR General science

Considerations for RT-qPCR in molecular point of care testing devices

Updated : Fri, April 15, 2022 @ 8:58 PM

The COVID-19 pandemic has accelerated the uptake of point of care testing (POCT), with simple, user-administered tests...

Read more

Oligo synthesis and modifications Nucleic acid therapeutics

Nucleic acid therapeutics for next-generation disease management

Updated : Tue, March 21, 2023 @ 3:44 PM

This is the first blog post in a two-part series exploring how oligonucleotide modifications can support the...

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qPCR SARS-CoV-2 General science

Society can’t handle the caveats to each type of COVID-19 test

Updated : Fri, February 11, 2022 @ 10:58 PM

But measurement science could help steer us in a better, more informed direction

COVID-19 tests can indicate the...

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Oligo synthesis and modifications

Leveraging quenching efficiency of Black Hole Quencher dyes for PCR and beyond

Updated : Tue, January 25, 2022 @ 8:30 PM

More innovative applications for Black Hole Quencher (BHQ) dyes

In imaging and detection assay development,...

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RNA FISH General science

Five ways controls can demystify your Stellaris™ RNA FISH experiment

Updated : Wed, March 22, 2023 @ 1:23 PM

Stellaris controls, who needs ‘em? We all do. Especially if it’s your first time interrogating a sample with a new...

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Agrigenomics qPCR PCR-based genotyping

Increasing hybrid rice breeding efficiency with high-throughput genotyping

Updated : Thu, January 12, 2023 @ 5:10 PM

Rice is the primary staple for more than half the world's population.1 With so many people relying on the crop for...

Read more

Oligo synthesis and modifications General science

Oligonucleotide synthesis basics: Key takeaways for post-synthesis processing

Updated : Wed, December 14, 2022 @ 4:45 PM

This is the final blog post in a three-part educational series about best practices for in-house oligonucleotide...

Read more

Molecular diagnostics Oligo synthesis and modifications

Innovative applications for Black Hole Quencher dyes

Updated : Tue, January 25, 2022 @ 10:23 PM

This is the first blog post in a two-part series highlighting how Black Hole Quencher™ dyes can be incorporated into...

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Oligo synthesis and modifications General science

Oligonucleotide synthesis basics: 4 key takeaways for in-house oligo production

Updated : Wed, December 14, 2022 @ 4:43 PM

This is the second blog post in a three-part educational series about best practices for in-house oligonucleotide...

Read more

qPCR General science

8 qPCR amplification plot questions answered

Updated : Thu, February 3, 2022 @ 6:10 PM

When results from your qPCR assays aren’t quite what you expected, it can be challenging to understand what went...

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Molecular diagnostics qPCR SARS-CoV-2 General science

Can COVID-19 testing be made more sustainable during prolonged uncertainty?

Updated : Thu, March 31, 2022 @ 3:24 PM

In September 2021, Delta persists as the most prevalent variant worldwide1 due to its high infectivity, causing surges...

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Oligo synthesis and modifications General science

Oligonucleotide synthesis basics: Introduction to phosphoramidite chemistry

Updated : Wed, December 14, 2022 @ 4:43 PM

This is the first blog post in a three-part educational series about best practices for in-house oligonucleotide...

Read more

Agrigenomics PCR-based genotyping Nucleic acid extraction

4 steps to optimise sample collection for aquaculture genotyping

Updated : Tue, September 7, 2021 @ 7:59 PM

Aquaculture breeding programmes adopt genomic technologies, including genotyping, to increase genetic gain for...

Read more

Agrigenomics Next generation sequencing (NGS) Nucleic acid extraction

The importance of sample processing for successful plant genotyping by NGS

Updated : Thu, August 12, 2021 @ 11:51 PM

Informed plant breeding decisions help drive the field of agrigenomics towards ever-increasing agricultural...

Read more

Agrigenomics Nucleic acid extraction

Don't underestimate the complexity of your sample composition

Updated : Wed, August 4, 2021 @ 9:34 PM

A common mistake when initiating an agrigenomics project is failing to consider specific sample composition before...

Read more

Agrigenomics Genomics General science

Selective breeding in aquaculture: advancing breeding programmes through genomics

Updated : Wed, December 14, 2022 @ 1:44 PM

The global demand for fish and fish products continues to increase as consumers focus on health-conscious ways to...

Read more

Molecular diagnostics Genomics SARS-CoV-2 General science

Genomic surveillance: 3 techniques to detect and characterise SARS-CoV-2 variants

Updated : Thu, March 9, 2023 @ 5:37 PM

As the global population gains greater access to vaccines for COVID-19, scientists and health officials continue to...

Read more

Agrigenomics Genomics NGS-based genotyping

Best practices for implementing targeted genotyping by sequencing

Updated : Fri, November 20, 2020 @ 5:16 PM

In breeding programmes, selections based on a single or small number of markers to target traits in marker assisted...

Read more

Molecular diagnostics Genomics SARS-CoV-2 General science

Building resilience into SARS-CoV-2 testing workflows: considerations for choosing an RNA isolation method

Updated : Thu, February 3, 2022 @ 4:39 PM

Clinical and diagnostic labs worldwide are still experiencing supply chain challenges with their SARS-CoV-2 testing...

Read more

Genomics PCR-based genotyping

How high-throughput genotyping automation and KASP marker libraries connect research labs with commercial breeders to accelerate crop improvement

Updated : Wed, October 7, 2020 @ 4:33 PM

“In July of 2015, I was a member of the radish genome project team. My task was to examine genetic diversity of radish...

Read more

Agrigenomics Genomics PCR-based genotyping

Employee spotlight: Meet Darshna "Dusty" Vyas

Updated : Fri, September 11, 2020 @ 9:52 PM

Darshna "Dusty" Vyas has been a Senior Scientist at LGC specialising in plant genetics for the past 8 years Her...

Read more

Molecular diagnostics Genomics SARS-CoV-2

Pressing COVID-19 testing issues of today and the near future

Updated : Tue, October 6, 2020 @ 6:45 PM

Following up with the panelists from our recent COVID-19 webinar, Part 3 of 3

In the previous two blog posts in this...

Read more

Molecular diagnostics Genomics SARS-CoV-2

Sensitivity and accuracy in COVID-19 testing

Updated : Tue, October 6, 2020 @ 6:42 PM

Following up with the panelists from our recent COVID-19 webinar, Part 2 of 3

In the face of a rapidly evolving...

Read more

Molecular diagnostics Genomics SARS-CoV-2

Scaling up COVID-19 viral testing

Updated : Tue, October 6, 2020 @ 6:45 PM

Following up with the panelists from our recent COVID-19 webinar, Part 1 of 3

The COVID-19 pandemic has presented...

Read more

Molecular diagnostics Genomics qPCR SARS-CoV-2

Enabling a rapid response to COVID-19 by Honeywell and LGC, Biosearch Technologies

Updated : Tue, October 6, 2020 @ 6:44 PM

As countries worldwide begin to ease lockdown restrictions during the pandemic and prepare to return to “normal”...

Read more

Agrigenomics Genomics PCR-based genotyping

Establishment of KASP marker library for genetic diversity analysis in Brassica rapa  crops

Updated : Tue, July 14, 2020 @ 1:30 PM

Brassica  rapa crops are important sources of food, feed, and fuel in many parts of the world and provide a unique...

Read more

Molecular diagnostics Genomics qPCR SARS-CoV-2

Robust supply chains and open testing systems: How our AgBio roots meet the FDA's EUA process to enable solutions to the COVID-19 pandemic

Updated : Fri, December 18, 2020 @ 8:49 PM

It may seem strange that a company known for transforming the global seed breeding industry is uniquely positioned...

Read more

Molecular diagnostics Oligo synthesis and modifications Genomics SARS-CoV-2 General science

Behind the scenes: How our oligo synthesis team contributes to the reliability of your assays

Updated : Wed, March 22, 2023 @ 1:52 PM

We’re not rejecting you, just your oligo

PCR is arguably one of the most enabling technologies of modern molecular...

Read more

Genomics Next generation sequencing (NGS) NGS-based genotyping

New NGS service lab now open in Middleton, WI for expanded global support

Updated : Wed, April 1, 2020 @ 8:12 PM

Back in September 2018, LGC acquired Lucigen Corporation. The ISO accredited site is based in Middleton, Wisconsin and...

Read more

Molecular diagnostics Oligo synthesis and modifications Genomics SARS-CoV-2

Addressing COVID-19 together: LGC, Biosearch Technologies and Shanghai Liferiver Biotechnology Co., Ltd.

Updated : Tue, October 6, 2020 @ 6:44 PM

In the nearly three months since the first confirmed case of COVID-19, the outbreak has become a global crisis, with...

Read more

Molecular diagnostics Genomics SARS-CoV-2 General science

What diagnostic test makers and CLIA labs in the US need to know about Emergency Use Authorization (EUA)

Updated : Tue, March 21, 2023 @ 3:41 PM

*Since the original publication of this blog, LGC Biosearch Technologies is now the only acceptable commercial supplier...

Read more

Molecular diagnostics Genomics SARS-CoV-2

Coronavirus outbreak: Collaboration to meet the challenge

{% video_player "embed_player" overrideable=False, type='scriptV4', hide_playlist=True, viral_sharing=False, embed_button=False, autoplay=False,...
Read more

Genomics PCR-based genotyping NGS-based genotyping

Back to basics - the crucial step of sample collection

Updated : Mon, January 13, 2020 @ 5:08 PM

Best practice in sample collection for SeqSNP targeted genotyping by sequencing projects

When good goes in, great...

Read more

Agrigenomics Genomics Next generation sequencing (NGS) NGS-based genotyping

Genomic selection: can it accelerate livestock breeding?

Updated : Wed, May 1, 2019 @ 3:59 PM

Livestock supports the livelihoods and food security of almost 1.3 billion people worldwide, contributing 40% of the...

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Genomics

The women of LGC, Biosearch Technologies

Updated : Fri, March 29, 2019 @ 4:39 PM

We've heard it said for years, "TV will rot your brain". But in the case of our three colleagues below, that definitely...

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Genomics NGS-based genotyping

Genomic selection: methods in crop and animal breeding

Updated : Wed, January 9, 2019 @ 5:03 PM

Genomic selection: 6 factors to consider when choosing between targeted GBS and microarrays

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Genomics General science

Revolutionising cancer treatment one Array at a time

Updated : Mon, September 19, 2022 @ 2:14 PM

While the science of pharmacogenomics has been around for years, its popularity is starting to pick up steam as...

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Genomics Nucleic acid extraction

Pack it up, pack it in, let me begin: A look at the future of DNA data storage

Updated : Thu, June 28, 2018 @ 4:28 PM

Imagine a time capsule the size of a shoebox that holds all the information currently on the internet that can be stored...

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RNA FISH Genomics

Warning! Pitfalls ahead: How to avoid the most common Stellaris RNA FISH mistakes

Updated : Tue, May 29, 2018 @ 3:47 PM

Ever wake up in the morning just feeling like a rock star, or maybe like Francis Crick, Rosalind Franklin or Maurice...

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RNA FISH Genomics

Shining a light on gene expression and regulation one cell at a time

Updated : Mon, April 30, 2018 @ 1:53 PM

To truly understand complex diseases such as cancer, scientists need access to tools that don’t just average data...

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Genomics

The Women of LGC

Updated : Thu, March 29, 2018 @ 4:00 PM

Ask any little girl what they want to be when they grow up and you may hear things like, princess, ballerina, pop star,...

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RNA FISH Genomics

In case you missed it: Stellaris RNA FISH lunch-and-learn

Updated : Tue, January 16, 2018 @ 4:50 PM

Stellaris® RNA FISH (fluorescence in situ hybridization) is an RNA visualization method that allows simultaneous...

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Agrigenomics Genomics NGS-based genotyping General science

Tackling food crisis through cost effective, target enriched sequencing

Updated : Mon, September 19, 2022 @ 2:16 PM

With the global population predicted to reach 9 billion people within the next 35 years, we will need to double the...

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Agrigenomics Genomics PCR-based genotyping

New SNPs identified in the hunt for new genetic weapons targeting leaf rust in wheat

Updated : Wed, November 22, 2017 @ 1:44 PM

Wheat is one of the three most important crops for human and livestock feed. With an ever-increasing global...

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Agrigenomics Genomics PCR-based genotyping

Super-crops helping to feed Africa

Updated : Tue, July 10, 2018 @ 9:08 PM

Our world population is growing at a tremendous rate and by 2050, Africa’s population alone is set to hit over 2.5...

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Genomics PCR-based genotyping Disease detection General science

How genotyping is aiding in the fight against malaria

Updated : Mon, September 19, 2022 @ 2:14 PM

3.2 billion people across 106 countries and territories, live in areas at risk of malaria transmission. The serious...

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RNA FISH Genomics General science

Lunch & Learn: Stellaris RNA FISH

Updated : Thu, July 6, 2017 @ 3:22 PM

Recently LGC Genomics hosted a lunch and learn Stellaris® seminar at the Helen Diller Cancer Institute at UCSF with our...

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Genomics qPCR General science

It’s official! Personal Health becomes first China demonstration laboratory site for LGC’s Nexar System

Updated : Mon, September 19, 2022 @ 2:07 PM

LGC's Genomics Division has signed a memorandum of understanding (MOU) with Chinese health management expert...

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qPCR General science

Digital PCR – improving reproducible molecular methods in the clinic

Updated : Thu, April 6, 2017 @ 3:40 PM

A recent study coordinated by LGC and published in the journal Analytical Chemistry, has demonstrated the potential of...

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RNA FISH Disease detection General science

Shining a light on how Zika virus may spread from mothers to human fetuses

Updated : Mon, March 6, 2017 @ 4:37 PM

New research has, for the first time, found evidence suggesting the molecular epidemiology of how the Zika virus spreads...

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Genomics PCR-based genotyping General science

Overcoming drought-intolerance in maize to feed the growing Asian population

Updated : Wed, February 15, 2017 @ 4:23 PM

Demand for maize is increasing due to an increased number of people transitioning to meat-based diets driving demand...

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Genomics General science

Automate to Accelerate and Scale-up SNP-based Genotyping Workflows!

Updated : Mon, September 19, 2022 @ 2:05 PM

The advent of and ongoing improvements to next-generation sequencing technologies is driving the continuing and...

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Genomics General science

Multiple Misunderstandings: Learning from Genetic Determinism

Updated : Mon, January 23, 2017 @ 4:27 PM

Nature versus nurture. It’s a tale as old as time.

When Craig Venter made the comment after the human genome sequence...

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Agrigenomics Genomics PCR-based genotyping NGS-based genotyping General science

Helping to Feed the World with Genotyping by Sequencing

Updated : Wed, January 18, 2017 @ 2:13 PM

Many areas critical to improved agricultural production require robust and scalable genotyping platforms to enable...

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Genomics qPCR General science

Multiplex your qPCR and Walk-away

Updated : Mon, September 19, 2022 @ 2:15 PM

It seems everyone wants to do more with less, and automate the process as well. But this can cause a number of...

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RNA FISH Genomics General science

A Stellar-is Year in the Making

Updated : Mon, September 19, 2022 @ 2:12 PM 

It wouldn't be fair to close out 2016 without showcasing the stellar year that Stellaris® RNA FISH has had. Take a...

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Genomics General science

Buddy Up: The Double Helix

Updated : Mon, November 28, 2016 @ 11:31 PM

The secret of life. That’s what Francis Crick and James Watson claimed they had discovered back in Cambridge,...

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Genomics General science

Genes, Proteins & DNA: Our Hereditary Software

Updated : Mon, November 21, 2016 @ 3:32 PM

In the early 1900s, scientists found that the function of genes was to make proteins, disproving the earlier idea...

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Genomics General science

"X" Marks the Spot: A closer look at chromosomes

Updated : Wed, March 29, 2023 @ 10:51 AM

The strands of DNA in your cells are organized into pieces called chromosomes. Chromosomes are further organized into...

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Genomics General science

Excel Autocorrect Fails the Genomics Community - Are your Results Excellent or Excel-not?

Updated : Mon, September 19, 2022 @ 2:13 PM

Researchers from the Baker IDI Heart and Diabetes Institute in Melbourne, Australia have blamed a default...

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qPCR General science

qPCR-based molecular diagnostics at the forefront of Zika surveillance

Updated : Wed, March 29, 2023 @ 11:04 AM

As the Zika virus outbreak spreads, a wave of international concern has grown, and scientists have scrambled to...

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Oligo synthesis and modifications General science

Know your oligo mod: Thio C6 linker

Updated : Wed, March 29, 2023 @ 10:55 AM

Thio C6 Linker (Thiohexyl) 

We continue our “Know Your Oligo Mod” series with another versatile custom oligonucleotide...

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Molecular diagnostics Oligo synthesis and modifications qPCR General science

Photoblog: Behind the scenes of oligo synthesis

Updated : Wed, December 14, 2022 @ 5:04 PM

OLIGO SYNTHESIS PHOTO GLIMPSE

We’ve recently captured our talented manufacturing teams hard at work building...

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qPCR General science

Nova is the new black

Updated : Mon, April 24, 2023 @ 8:54 AM

LGC Biosearch Technologies has developed a new qPCR probe format powered by Black Hole Quencher technology known as ...

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RNA FISH General science

Imaging Stellaris Assays Part III: Creating Professional, Publication-ready Images

Updated : Wed, August 16, 2017 @ 9:15 AM

Here is the final installment of our “Imaging Stellaris Assays” blog series. In our two previous posts, we’ve gone...

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RNA FISH General science

Designing Stellaris RNA FISH Probes Part I: Increasing Probe Count

Updated : Tue, September 27, 2022 @ 2:32 PM

Stellaris® RNA FISH is a novel technology that allows for the detection of single or clustered RNAs in fixed cells...

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Oligo synthesis and modifications qPCR General science

Know your oligo mod: 3' Spacer C3

Updated : Wed, March 29, 2023 @ 10:54 AM

This week, we continue our Know your oligo mod blog series and we will focus on a very basic, yet extremely versatile...

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RNA FISH General science

Imaging Stellaris Assays Part II: How to Acquire Stunning Images

Updated : Wed, August 16, 2017 @ 9:13 AM

Here we continue our “Imaging Stellaris Assays” blog series. We last left off talking about the most important...

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RNA FISH General science

Runaway RNA Stays Put

Updated : Tue, March 21, 2023 @ 3:53 PM

The cleavage and polyadenylation event, the final trimming in the molecular mRNA barbershop, normally releases both the...

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RNA FISH General science

Imaging Stellaris Assays Part I: Get to Know Your Microscope

Updated : Wed, August 16, 2017 @ 9:42 PM

Stellaris® FISH is an RNA detection technology performed by means of in situ hybridization. This technology and all of...

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Oligo synthesis and modifications General science

The AGCT’s of DNA synthesis

Updated : Wed, March 29, 2023 @ 10:38 AM

Chemically synthesized DNA has become an indispensable tool for molecular biologists in the fields of medicine,...

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Oligo synthesis and modifications General science

Know your oligo mod: BHQ® (Black Hole Quencher®) non-fluorescent quenchers

Updated : Fri, January 13, 2023 @ 11:35 AM

In this instalment, we will cover the basics of LGC Biosearch Technologies’ line of proprietary non-fluorescent...

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RNA FISH qPCR General science

And the Consensus (Sequence) is...

Updated : Fri, November 13, 2015 @ 9:25 PM

Studying the expression level of RNA transcripts is often complicated by the fact that many DNA sequences are...

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RNA FISH General science

Research Highlight: Bringing Vision Research into Focus

Updated : Tue, March 21, 2023 @ 3:37 PM

Gene expression and molecular biology research in vision and ophthalmology presents unique challenges to researchers...

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RNA FISH General science

FISH-ing for Fusions: A unique approach to fusion gene mRNA & pre-mRNA detection in cancer

Updated : Fri, November 13, 2015 @ 10:27 PM

This past April, Biosearch attended the American Association of Cancer Research (AACR) conference in Philadelphia,...

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qPCR General science

How Much is Your qPCR Assay Really Costing You?

Updated : Fri, November 13, 2015 @ 10:40 PM

In the setup of a qPCR experiment, one of the first decisions to make is which detection method to use. This...

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RNA FISH General science

The 4Cs of Stellaris® RNA FISH Buffers

Updated : Mon, November 16, 2015 @ 3:55 PM 

Buffers are often overlooked and taken for granted until the day comes when a peculiar result is observed and its...

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Oligo synthesis and modifications General science

Know your oligo mod: phosphorothioate bonds

Updated : Wed, March 29, 2023 @ 10:56 AM

This post in our continuing series, “Know your oligo mod” will cover phosphorothioate bonds, which are available for...

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qPCR General science

Optimising multiplex competitive qRT-PCR in diagnostics with BHQplus probes

Updated : Mon, November 16, 2015 @ 5:30 PM

In a webinar linked below, Dr. James Willey describes a two colour fluorometric assay for more robust quantitation...

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qPCR PCR-based genotyping General science

A Successful Duo for Accurate, Speedy, and Economical SNP Genotyping

Updated : Mon, September 19, 2022 @ 2:12 PM

Single Nucleotide Polymorphisms (SNPs) have been widely studied for over 15 years, and have applications in...

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About LGC, Biosearch Technologies

LGC, Biosearch Technologies is the complete Genomics portfolio from LGC. Providing genomic analysis tools, instrumentation and services to the genomic scientific discovery sector worldwide, with focus on across ag bio, pharma and molecular diagnostics. Visit our home page to view our products and services.

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