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The success of a nucleic acid therapeutic is highly dependent on the modifications made to the nucleotides. These mods...
- Agrigenomics
- CPG
- Disease detection
- Enzymes
- General science
- Genomics
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- Molecular diagnostics
- mRNA therapeutics
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- PCR-based genotyping
- qPCR
- RNA FISH
- SARS-CoV-2
- Targeted GBS
Human Healthcare
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General Science
New and Featured Enzymes mRNA therapeutics
The rapid development of the mRNA vaccines for COVID-19 was only possible thanks to earlier years of research into the...
In April 2025, the MIQE guidelines for quantitative real-time PCR (qPCR) were updated for the first time since their...
Agrigenomics Nucleic acid extraction
Rapid DNA purification kit reduces the seed genotyping workflow by almost a week
For many labs, the ability to deliver...
Getting multiple qPCR results at the same time in the same well is extremely valuable for assay developers. The time...
Multiplex qPCR is a popular way of enhancing assays by combining multiple reactions in a single well. This approach can...
Oligo synthesis and modifications Nucleic acid therapeutics
The core part of oligonucleotide therapeutics is the carefully refined sequence of nucleotides that precisely binds the...
Agrigenomics Next generation sequencing (NGS) Targeted GBS
By Dusty Vyas, Senior Scientist at LGC Biosearch Technologies
Genomics Enzymes mRNA therapeutics
Updated : Friday, 31 January, 2025 @ 9:10 AM CT
Just as enzymes are the workhorses of our cells, they continue to play...
Oligo synthesis and modifications
An amino linker is perhaps the most versatile of all the modifications you can add to an oligonucleotide. Its primary...
Oligo synthesis and modifications
Locked nucleic acids are an increasingly popular modification for tailoring and improving the performance of...
Although PCR remains the gold-standard technique for molecular diagnostics assays, PCR misses the mark for applications...
Agrigenomics Next generation sequencing (NGS) Targeted GBS
Environmental DNA (eDNA) is genetic material extracted from the environment from the likes of water, soil, sediment, sa...
Oligo synthesis and modifications
In our latest ‘Know your oligo mod’ post, we look at the impact of 5-methyl deoxycytidine – a modified nucleoside that...
Agrigenomics Next generation sequencing (NGS) Targeted GBS
By Austin Sheppe PhD, LGC Biosearch Technologies withcontributionsby Dusty Vyas, Senior Scientist LGC Biosearch T...
Molecular diagnostics NGS-based genotyping Nucleic acid extraction
Our scientists and product specialists work in close collaboration with a diverse range of customers to find solutions...
Genomics Nucleic acid therapeutics
Dozens of oligonucleotide-based therapeutics are already on the market, helping to treat a range of life-threatening...
Genomics Nucleic acid therapeutics
With the rapid deployment of the mRNA COVID-19 vaccines and the recent approval of the first CRISPR gene therapy, the...
African forest elephants are considered a keystone species due to their positive impact on the forest ecosystem. As the...
qPCR PCR-based genotyping oligos probes and primers
Need high specificity and shorter probes for your hybridisation assays? If you are considering Minor Groove Binder...
Sorghum[Sorghum bicolor (L.) Moench] is a diploid cereal crop used for food, drink (beer), livestock feed, fuel and as...
Molecular diagnostics Disease detection
Although PCR is often viewed as a gold standard for molecular diagnostic tests, the problem of non-specific primer...
Oligo synthesis and modifications qPCR NGS-based genotyping KASP CPG
Our scientists can’t agree!
Our portfolio covers a wide range of products supporting research, development and...
Oligo synthesis and modifications
The "Know your oligo mod" series continues with a deep dive into the 2'-O-methoxyethyl (2'-MOE) modification, a major...
Molecular diagnostics Disease detection
Detecting single nucleotide variations (SNVs) offers powerful actionable insights in diagnosing diseases, monitoring...
With more companies than ever innovating in precision medicine, drug discovery, therapeuticdevelopment and genetic...
Oligo synthesis and modifications
In this latest instalment of our 'Know Your Oligo Mod' blog series, we explore the benefits of high-performance ATTO...
Oligo synthesis and modifications
In November 2023, the UK became the first country in the world to approve a gene therapy based on CRISPR-Cas9...
Creating a crop that is more effective at meeting the needs of farmers and end consumers is the aim of every plant...
Molecular diagnostics Disease detection
Since Humira (adalimumab) became the first approved monoclonal antibody therapy developed using phage display in 2002,...
Agrigenomics Next generation sequencing (NGS) NGS-based genotyping
Potato (Solanum tuberosum) is the world’s third most important food crop after wheat and cereal and is a staple food...
Molecular diagnostics Genomics
Image credit: HIV Reverse Transcriptase. RCSB Protein Data Bank. The Wellcome Collection.
qPCR testing is usually the method of choice when high sensitivity and specificity are required. For instance, in...
Disease detection Nucleic acid therapeutics
While RNA-based therapeutics are taking the biotechnology world by storm following the rapid development of the...
Oligo synthesis and modifications Nucleic acid therapeutics
Considering bringing oligo synthesis in-house? Here are some commonly asked questions that we receive, grouped into...
The recent Nobel Prize awarded to Katalin Karikó and Drew Weissman underlined the impact their breakthroughs in mRNA...
Agrigenomics Next generation sequencing (NGS) NGS-based genotyping
How does genomic selection increase profitability?
Livestock farmers’ and breeders’ profitability is directly related...
Molecular diagnostics Disease detection
As the world scrambled to rapidly expand PCR testing capacity in 2020, it became increasingly clear that there was a...
Oligo synthesis and modifications
Labelling, linking or modifying biomolecules used to be a laborious process, requiring customised complex synthetic...
Antimicrobial resistance (AMR) across bacterial species is developing rapidly, compounded by the improper use of...
Agrigenomics NGS-based genotyping
Every year over 1.5 million tonnes of blueberries and over half a million tonnes of cranberries are produced. This is...
Oligo synthesis and modifications Nucleic acid therapeutics
Updated : Fri, July 7, 2023
Over the last few decades, researchers have made impressive strides in developing...
Molecular diagnostics Nucleic acid extraction
Updated : Thu, June 29, 2023
Whether you’re working with samples for PCR or sequencing, it's worth questioning...
Updated : Thu, June 1, 2023 @ 4:09 PM
Oil palm, Elaeis guineensis Jacq., is the most productive oil crop in the world1...
Updated : Fri, May 26, 2023 @ 10:18 AM
Designing a new assay and scaling it for commercial use takes thoughtful...
Updated : Tue, May 9, 2023 @ 11:03 AM
When it comes to oligonucleotide therapeutics, the challenge has always been how...
Molecular diagnostics Oligo synthesis and modifications qPCR
Updated : Fri, May 5, 2023 @ 2:34 PM
How does a BHQ dye contribute to producing superior data from your assays?
Oligo synthesis and modifications Nucleic acid therapeutics
Updated : Mon, June 26, 2023 @ 10:24 AM
Oligonucleotide therapeutics have unlocked new treatment possibilities for rare...
Agrigenomics PCR-based genotyping
Updated : Tue, May 9, 2023 @ 10:48 AM
Around 159,200 tonnes of strawberries are produced annually in Japan across 5,020...
Oligo synthesis and modifications
Updated : Tue, May 9, 2023 @ 10:51 AM
In the next edition of the “Know your oligo mod” series, we look at a universal...
Updated : Tue, May 9, 2023 @ 10:53 AM
This International Day of Women and Girls in Science (11 February) LGC Biosearch...
Agrigenomics PCR-based genotyping
Updated : Wed, March 22, 2023 @ 1:48 PM
Genotyping plants can be a complex and frustrating process
Molecular diagnostics SARS-CoV-2 Disease detection
Updated : Tue, May 9, 2023 @ 10:57 AM
We were delighted to attend the Association for Molecular Pathology (AMP) 2022...
Molecular diagnostics Oligo synthesis and modifications
Updated : Tue, May 9, 2023 @ 11:01 AM
Originally developed in the early 1990s, aptamers have long been heralded as an...
Molecular diagnostics Nucleic acid extraction
Updated : Tue, May 9, 2023 @ 11:05 AM
Molecular testing protocols for pathogen detection and diagnosing human diseases...
Agrigenomics PCR-based genotyping
Updated : Wed, March 22, 2023 @ 1:22 PM
Modern agriculture faces unprecedented challenges: increasing global...
Updated : Wed, December 14, 2022 @ 1:54 PM
When the polymerase chain reaction (PCR) was first described, the Klenow...
Oligo synthesis and modifications Nucleic acid therapeutics
Updated : Tue, August 9, 2022 @ 7:10 PM
New approaches that use aptamers as targeting agents may open the door to wider...
Molecular diagnostics Oligo synthesis and modifications qPCR
Updated : Tue, May 9, 2023 @ 10:40 AM
Let the application be your guide when deciding between LNA, MGB and BHQplus
The...
Molecular diagnostics Disease detection
Updated : Thu, July 7, 2022
Since 13 May 2022, reports of monkeypox cases began to appear globally in regions not...
Agrigenomics PCR-based genotyping NGS-based genotyping
Updated : Mon, April 17, 2023 @ 8:33 AM
This is the second blog in a two-part series exploring solutions for infectious...
SARS-CoV-2 Nucleic acid extraction Disease detection
Updated : Fri, December 16, 2022 @ 3:39 PM
Since early 2020, diagnostic laboratories have had to manage patient sample...
Updated : Mon, April 17, 2023 @ 1:33 PM
This is the first blog in a two-part series exploring solutions for infectious...
Updated : Tue, March 21, 2023 @ 3:23 PM
What’s changed for clinical labs as we enter the third year of COVID-19 testing?
Updated : Wed, March 30, 2022 @ 4:00 PM
While both centralised and decentralised molecular diagnostics (MDx) testing...
Oligo synthesis and modifications Nucleic acid therapeutics
Updated : Tue, March 21, 2023 @ 3:46 PM
This is the second blog in a two-part series exploring how oligonucleotide...
Agrigenomics qPCR PCR-based genotyping
Updated : Wed, March 9, 2022 @ 1:05 AM
African oil palm (Elaeis guineensis Jacq.) is a highly productive perennial crop...
Updated : Fri, April 15, 2022 @ 8:58 PM
The COVID-19 pandemic has accelerated the uptake of point of care testing...
Oligo synthesis and modifications Nucleic acid therapeutics
Updated : Tue, March 21, 2023 @ 3:44 PM
This is the first blog post in a two-part series exploring how oligonucleotide...
Updated : Fri, February 11, 2022 @ 10:58 PM
But measurement science could help steer us in a better, more informed...
Oligo synthesis and modifications
Updated : Tue, January 25, 2022 @ 8:30 PM
More innovative applications for Black Hole Quencher (BHQ) dyes
In imaging...
Updated : Wed, March 22, 2023 @ 1:23 PM
Stellaris controls, who needs ‘em? We all do. Especially if it’s your first...
Agrigenomics qPCR PCR-based genotyping
Updated : Thu, January 12, 2023 @ 5:10 PM
Rice is the primary staple for more than half the world's population.1 With...
Updated : Tue, January 11, 2022 @ 6:00 PM
What’s changed for clinical labs as we enter the third year of COVID-19...
Updated : Tue, December 28, 2021 @ 3:30 PM
What’s changed for clinical labs as we enter the third year of COVID-19...
Molecular diagnostics SARS-CoV-2
Updated : Wed, March 22, 2023 @ 2:01 PM
The emergence of the Omicron lineage has quickly escalated to be a variant of...
Updated : Thu, March 9, 2023 @ 5:39 PM
What’s changed for clinical labs as we enter the third year of COVID-19 testing?
Oligo synthesis and modifications
Updated : Wed, December 14, 2022 @ 4:45 PM
This is the final blog post in a three-part educational series about best...
Molecular diagnostics SARS-CoV-2
Updated : Fri, December 10, 2021 @ 2:34 AM
On 22 November 2021, The Network for Genomics Surveillance in South Africa...
Agrigenomics Next generation sequencing (NGS) NGS-based genotyping
Updated : Tue, December 7, 2021 @ 10:11 PM
The decisions made by molecular breeding programmes have a substantial...
| We're excited to announce that the proposal to extend certain key provisions of the In Vitro Diagnostic Regulation... |
Molecular diagnostics SARS-CoV-2 Disease detection
Updated : Tue, November 30, 2021 @ 10:29 PM
A fourth wave of COVID-19 has already emerged in many countries and a newly...
Agrigenomics NGS-based genotyping
Updated : Fri, June 30, 2023 @ 2:19 PM
Many cultivated crops with agronomic significance, including wheat, peanut, oat,...
Molecular diagnostics Oligo synthesis and modifications
Updated : Tue, January 25, 2022 @ 10:23 PM
This is the first blog post in a two-part series highlighting how Black Hole...
Oligo synthesis and modifications
Updated : Wed, December 14, 2022 @ 4:43 PM
This is the second blog post in a three-part educational series about best...
Molecular diagnostics SARS-CoV-2
Updated : Thu, October 14, 2021 @ 10:01 PM
SARS-CoV-2 mutations and associated new variants are being reported...
Updated : Thu, February 3, 2022 @ 6:10 PM
When results from your qPCR assays aren’t quite what you expected, it can be...
Molecular diagnostics qPCR SARS-CoV-2
Updated : Thu, March 31, 2022 @ 3:24 PM
In September 2021, Delta persists as the most prevalent variant worldwide1 due...
Updated : Wed, September 15, 2021 @ 4:40 AM
A shortcut to understanding how to prepare for IVDR
In today’s global...
Oligo synthesis and modifications
Updated : Wed, December 14, 2022 @ 4:43 PM
This is the first blog post in a three-part educational series about best...
Agrigenomics PCR-based genotyping Nucleic acid extraction
Updated : Tue, September 7, 2021 @ 7:59 PM
Aquaculture breeding programmes adopt genomic technologies, including...
Molecular diagnostics SARS-CoV-2
Updated : Wed, November 9, 2022 @ 8:20 PM
The COVID-19 pandemic brought tremendous change to the molecular diagnostics...
Updated : Thu, September 29, 2022 @ 7:57 PM
As SARS-CoV-2 variants continue to threaten public health, officials are...
Updated : Thu, December 16, 2021 @ 6:46 PM
Emerging SARS-CoV-2 variants of concern and variants of interest are defined...
Agrigenomics Next generation sequencing (NGS) Nucleic acid extraction
Updated : Thu, August 12, 2021 @ 11:51 PM
Informed plant breeding decisions help drive the field of agrigenomics...
Agrigenomics Nucleic acid extraction
Updated : Wed, August 4, 2021 @ 9:34 PM
A common mistake when initiating an agrigenomics project is failing to consider...
Updated : Wed, December 14, 2022 @ 1:44 PM
The global demand for fish and fish products continues to increase as...
Molecular diagnostics Genomics SARS-CoV-2
Updated : Thu, March 9, 2023 @ 5:37 PM
As the global population gains greater access to vaccines for COVID-19,...
Molecular diagnostics SARS-CoV-2
Updated : Thu, March 9, 2023 @ 5:34 PM
Researchers have identified several variants of SARS-CoV-2 since they sequenced...
Agrigenomics Genomics NGS-based genotyping
Updated : Fri, November 20, 2020 @ 5:16 PM
In breeding programmes, selections based on a single or small number of...
Molecular diagnostics Genomics SARS-CoV-2
Updated : Thu, February 3, 2022 @ 4:39 PM
Clinical and diagnostic labs worldwide are still experiencing supply chain...
Updated : Wed, October 7, 2020 @ 4:33 PM
“In July of 2015, I was a member of the radish genome project team. My task...
Agrigenomics Genomics PCR-based genotyping
Updated : Fri, September 11, 2020 @ 9:52 PM
Darshna "Dusty" Vyas has been a Senior Scientist at LGC specialising in...
Molecular diagnostics Genomics SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:45 PM
Following up with the panelists from our recent COVID-19 webinar, Part 3 of 3
...
Molecular diagnostics Genomics SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:42 PM
Following up with the panelists from our recent COVID-19 webinar, Part 2 of 3
...
Molecular diagnostics Genomics SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:45 PM
Following up with the panelists from our recent COVID-19 webinar, Part 1 of 3
...
Molecular diagnostics Genomics qPCR SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:44 PM
As countries worldwide begin to ease lockdown restrictions during the pandemic...
Agrigenomics Genomics PCR-based genotyping
Updated : Tue, July 14, 2020 @ 1:30 PM
Brassica rapa crops are important sources of food, feed, and fuel in many parts...
Molecular diagnostics Genomics qPCR SARS-CoV-2
Updated : Fri, December 18, 2020 @ 8:49 PM
It may seem strange that a company known for transforming the global seed...
Molecular diagnostics Oligo synthesis and modifications Genomics SARS-CoV-2
Updated : Wed, March 22, 2023 @ 1:52 PM
We’re not rejecting you, just your oligo
PCR is arguably one of the most...
Molecular diagnostics SARS-CoV-2
Updated : Wed, November 25, 2020 @ 8:23 PM
On March 25, 2020, the US Food and Drug Administration (FDA) held the first...
Genomics Next generation sequencing (NGS) NGS-based genotyping
Updated : Wed, April 1, 2020 @ 8:12 PM
Back in September 2018, LGC acquired Lucigen Corporation. The ISO accredited...
Molecular diagnostics Oligo synthesis and modifications Genomics SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:44 PM
In the nearly three months since the first confirmed case of COVID-19, the...
Molecular diagnostics Genomics SARS-CoV-2
Updated : Tue, March 21, 2023 @ 3:41 PM
*Since the original publication of this blog, LGC Biosearch Technologies is now...
Molecular diagnostics Genomics SARS-CoV-2
{% video_player "embed_player" overrideable=False, type='scriptV4', hide_playlist=True, viral_sharing=False,...
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Molecular diagnostics Next generation sequencing (NGS)
Updated : Tue, October 11, 2022 @ 8:43 PM
The development of new genomic sequencing techniques and bioinformatics...
Genomics PCR-based genotyping NGS-based genotyping
Updated : Mon, January 13, 2020 @ 5:08 PM
Best practice in sample collection for SeqSNP targeted genotyping by...
Agrigenomics Genomics Next generation sequencing (NGS) NGS-based genotyping
Updated : Wed, May 1, 2019 @ 3:59 PM
Livestock supports the livelihoods and food security of almost 1.3 billion people...
Updated : Fri, March 29, 2019 @ 4:39 PM
We've heard it said for years, "TV will rot your brain". But in the case of our...
Agrigenomics PCR-based genotyping Next generation sequencing (NGS) NGS-based genotyping
Updated : Fri, May 19, 2023 @ 8:53 AM
“Experience of artificial fertilisation, such as is effected with ornamental...
Agrigenomics Next generation sequencing (NGS) NGS-based genotyping
Updated : Thu, May 25, 2023 @ 11:32 AM
Plant and animal breeding programmes often take generations to improve quality...
Updated : Wed, January 9, 2019 @ 5:03 PM
Genomic selection: 6 factors to consider when choosing between targeted GBS...
Agrigenomics Next generation sequencing (NGS) NGS-based genotyping
Updated : Tue, December 11, 2018 @ 4:32 PM
Food security is a major global threat and traditional methods of plant and...
Updated : Thu, July 26, 2018 @ 4:41 PM
Diversity is the spice of life and is also key to breeding rice that delivers...
Updated : Mon, September 19, 2022 @ 2:14 PM
While the science of pharmacogenomics has been around for years, its...
Genomics Nucleic acid extraction
Updated : Thu, June 28, 2018 @ 4:28 PM
Imagine a time capsule the size of a shoebox that holds all the information...
Updated : Tue, May 29, 2018 @ 3:47 PM
Ever wake up in the morning just feeling like a rock star, or maybe like Francis...
Updated : Mon, April 30, 2018 @ 1:53 PM
To truly understand complex diseases such as cancer, scientists need access to...
Updated : Thu, March 29, 2018 @ 4:00 PM
Ask any little girl what they want to be when they grow up and you may hear...
Updated : Tue, January 16, 2018 @ 4:50 PM
Stellaris® RNA FISH (fluorescence in situ hybridization) is an RNA...
Agrigenomics Genomics PCR-based genotyping
Updated : Wed, November 22, 2017 @ 1:44 PM
Wheat is one of the three most important crops for human and livestock feed....
Agrigenomics Genomics PCR-based genotyping
Updated : Tue, July 10, 2018 @ 9:08 PM
Our world population is growing at a tremendous rate and by 2050, Africa’s...
Genomics PCR-based genotyping Disease detection
Updated : Mon, September 19, 2022 @ 2:14 PM
3.2 billion people across 106 countries and territories, live in areas at...
Updated : Thu, July 6, 2017 @ 3:22 PM
Recently LGC Genomics hosted a lunch and learn Stellaris® seminar at the Helen...
Updated : Mon, September 19, 2022 @ 2:07 PM
LGC's Genomics Division has signed a memorandum of understanding (MOU) with...
Updated : Mon, March 6, 2017 @ 4:37 PM
New research has, for the first time, found evidence suggesting the molecular...
Updated : Mon, September 19, 2022 @ 2:20 PM
It’s time to forget what you know about heating your PCR plates for...
Updated : Wed, February 15, 2017 @ 4:23 PM
Demand for maize is increasing due to an increased number of people...
Updated : Mon, September 19, 2022 @ 2:05 PM
The advent of and ongoing improvements to next-generation sequencing...
Updated : Mon, January 23, 2017 @ 4:27 PM
Nature versus nurture. It’s a tale as old as time.
When Craig Venter made the...
Agrigenomics Genomics PCR-based genotyping NGS-based genotyping
Updated : Wed, January 18, 2017 @ 2:13 PM
Many areas critical to improved agricultural production require robust and...
Updated : Mon, January 9, 2017 @ 3:20 PM
Screen more markers faster and bring crops with superior traits to the market...
Updated : Mon, September 19, 2022 @ 2:15 PM
It seems everyone wants to do more with less, and automate the process as...
Updated : Mon, September 19, 2022 @ 2:12 PM
It wouldn't be fair to close out 2016 without showcasing the stellar year...
Updated : Mon, November 28, 2016 @ 11:31 PM
The secret of life. That’s what Francis Crick and James Watson claimed they...
Updated : Mon, November 21, 2016 @ 3:32 PM
In the early 1900s, scientists found that the function of genes was to make...
Updated : Wed, March 29, 2023 @ 10:51 AM
The strands of DNA in your cells are organized into pieces called chromosomes....
Updated : Mon, September 19, 2022 @ 2:13 PM
Researchers from the Baker IDI Heart and Diabetes Institute in Melbourne,...
Updated : Wed, March 29, 2023 @ 11:04 AM
As the Zika virus outbreak spreads, a wave of international concern has grown,...
Oligo synthesis and modifications
Updated : Wed, March 29, 2023 @ 10:55 AM
Thio C6 Linker (Thiohexyl)
We continue our “Know Your Oligo Mod” series with...
![A Complete Ecosystem to Accelerate Breeding Programs [Infographic]](http://blog.biosearchtech.com/hubfs/images/ecosystem-hero-banner1600x712.jpg)
Updated : Tue, June 28, 2016 @ 9:00 PM
Modern breeding methods rely on the identification and utilization of molecular...
Molecular diagnostics Oligo synthesis and modifications qPCR
Updated : Wed, December 14, 2022 @ 5:04 PM
OLIGO SYNTHESIS PHOTO GLIMPSE
We’ve recently captured our talented...
Updated : Mon, April 24, 2023 @ 8:54 AM
LGC Biosearch Technologies has developed a new qPCR probe format powered by...
Updated : Thu, March 31, 2016 @ 9:01 PM
At this year’s 24th annual Plant & Animal Genome (PAG) conference, LGC...
Updated : Wed, August 16, 2017 @ 9:15 AM
Here is the final installment of our “Imaging Stellaris Assays” blog series....
Updated : Tue, September 27, 2022 @ 2:32 PM
Stellaris® RNA FISH is a novel technology that allows for the detection of...
Oligo synthesis and modifications qPCR
Updated : Wed, March 29, 2023 @ 10:54 AM
This week, we continue our Know your oligo mod blog series and we will focus...
Updated : Wed, August 16, 2017 @ 9:13 AM
Here we continue our “Imaging Stellaris Assays” blog series. We last left off...
Updated : Tue, March 21, 2023 @ 3:53 PM
The cleavage and polyadenylation event, the final trimming in the molecular...
Updated : Wed, August 16, 2017 @ 9:42 PM
Stellaris® FISH is an RNA detection technology performed by means of in situ...
Oligo synthesis and modifications
Updated : Wed, March 29, 2023 @ 10:38 AM
Chemically synthesized DNA has become an indispensable tool for molecular...
Oligo synthesis and modifications
Updated : Fri, January 13, 2023 @ 11:35 AM
In this instalment, we will cover the basics of LGC Biosearch Technologies’...
Updated : Fri, November 13, 2015 @ 9:25 PM
Studying the expression level of RNA transcripts is often complicated by the...
Updated : Tue, March 21, 2023 @ 3:37 PM
Gene expression and molecular biology research in vision and ophthalmology...
Updated : Fri, November 13, 2015 @ 10:27 PM
This past April, Biosearch attended the American Association of Cancer...
Updated : Fri, November 13, 2015 @ 10:40 PM
In the setup of a qPCR experiment, one of the first decisions to make is...
Updated : Mon, November 16, 2015 @ 3:55 PM
Buffers are often overlooked and taken for granted until the day comes when...
Oligo synthesis and modifications
Updated : Wed, March 29, 2023 @ 10:56 AM
As part of our “Know your oligo mod” blog series, we cover phosphorothioate...
Updated : Mon, November 16, 2015 @ 5:30 PM
In a webinar linked below, Dr. James Willey describes a two colour...
Updated : Mon, September 19, 2022 @ 2:12 PM
Single Nucleotide Polymorphisms (SNPs) have been widely studied for over 15...
Oligo synthesis and modifications
Updated : Wed, March 29, 2023 @ 10:56 AM
The chemical synthesis of oligonucleotides allows for the incorporation of a...
Updated : Mon, September 19, 2022 @ 2:14 PM
Neuroscience gene expression research can come with many hurdles,...
Oligo synthesis and modifications qPCR
Updated : Tue, October 14, 2014 @ 10:21 PM
Different oligonucleotide manufacturers deliver probes and primers in a...
Updated : Mon, September 19, 2022 @ 2:13 PM
The largest recorded Ebola Virus Disease outbreak in history continues to...
Updated : Mon, September 19, 2022 @ 2:12 PM
Don’t waste time performing an extra step. Cut back on pipetting and order...
Updated : Tue, March 21, 2023 @ 3:52 PM
Do you remember when the most popular method of DNA amplification involved...
Updated : Mon, September 19, 2022 @ 2:10 PM
A "Referral from the Doctor" Blog Article-
Quantitative reverse...
Updated : Mon, September 19, 2022 @ 2:13 PM
Biosearch Technologies, Inc. (Biosearch) announced today that the company...
Updated : Wed, October 1, 2014 @ 4:53 PM
Stellaris probe sets targeting glyceraldehyde-3-phosphate dehydrogenase...
Updated : Mon, September 19, 2022 @ 2:07 PM
Biosearch Technologies, Inc. (Biosearch), a leading supplier of...
Updated : Wed, October 1, 2014 @ 4:53 PM
Biosearch Technologies, Inc. (Biosearch), a leading supplier of...
Updated : Mon, September 19, 2022 @ 2:07 PM
Biosearch Technologies, Inc. (Biosearch), a leading supplier of...
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A...
Updated : Wed, October 1, 2014 @ 4:51 PM
Non-squamous, Non-small cell lung cancer (NSCLC), the most common cause of...
Updated : Fri, October 21, 2022 @ 10:24 AM
Fluorophores are molecules that can absorb light energy in a process called...
Updated : Mon, September 19, 2022 @ 2:10 PM
A "Referral from the Doctor" Blog Article-
The mathematical model of PCR...
Updated : Mon, September 19, 2022 @ 2:10 PM
A "Referral from the Doctor" Blog Article-
Fluorescent probes are used in...
Updated : Mon, September 19, 2022 @ 2:10 PM
A "Referral from the Doctor" Blog Article-
Quantitative real-time PCR...
Updated : Thu, May 11, 2023 @ 10:06 AM
If you run quantitative real-time PCR (qPCR) assays, the chances are that...
Updated : Mon, September 19, 2022 @ 2:10 PM
A "Referral from the Doctor" Blog Article-
ROX in qPCR
Quantitative...
Updated : Mon, September 19, 2022 @ 2:07 PM
Biosearch Technologies is proud to sponsor the first IVD Technology...
Updated : Wed, October 1, 2014 @ 4:42 PM
It can be difficult to transition a product from research to...
Updated : Mon, September 19, 2022 @ 2:14 PM
A "Referral from the Doctor" Blog Article-
Research trends in laboratories...
Updated : Thu, March 23, 2023 @ 11:57 AM
Scorpions™ Primers are dual-labeled FRET probes that combine a Molecular...
Updated : Mon, March 20, 2023 @ 9:54 PM
Molecular Beacons are a special type of dual-labeled oligonucleotide probe....
Updated : Mon, September 19, 2022 @ 2:10 PM
A "Referral from the Doctor" Blog Article
A BHQ® probe is a dual-labeled...
Updated : Mon, September 19, 2022 @ 2:10 PM
A "Referral from the Doctor" Blog Article-
The aim of the Polymerase...
Updated : Wed, October 1, 2014 @ 4:38 PM
At the third qPCR Symposium, held November 9th -12th in Millbrae, CA, ETS...
Updated : Wed, December 14, 2022 @ 4:20 PM
A "Referral from the Doctor" Blog Article-
Genomic DNA contamination has...
Updated : Thu, September 22, 2022 @ 5:16 PM
By now, you've no doubt read about the reductions in error, cost and time...
Updated : Mon, September 19, 2022 @ 2:10 PM
A "Referral from the Doctor" Blog Article-
ε = m.c.2 (shall I explain?...
Updated : Mon, September 19, 2022 @ 2:10 PM
A "Referral from the Doctor" Blog Article-
Competitive qRT-PCR has become...
Oligo synthesis and modifications qPCR
Updated : 2 May 2024 @ 2:10 PM
Quantitative reverse transcription PCR (RT-qPCR) is commonly used to measure gene...
Updated : Mon, September 19, 2022 @ 2:10 PM
A "Referral from the Doctor" Blog Article-
Top 10 Reference Genes for...
Oligo synthesis and modifications qPCR
Updated : Fri, January 13, 2023 @ 11:38 AM
When to use an internal Black Hole Quencher (BHQ) label in a...
Oligo synthesis and modifications qPCR
Updated : Mon, September 19, 2022 @ 2:12 PM
Biosearch Technologies will now be offering the option of salt-free...
Oligo synthesis and modifications Nucleic acid therapeutics
The success of a nucleic acid therapeutic is highly dependent on the modifications made to the nucleotides. These mods play a key role in providing the...
In April 2025, the MIQE guidelines for quantitative real-time PCR (qPCR) were updated for the first time since their initial release in 2009. This latest...
Getting multiple qPCR results at the same time in the same well is extremely valuable for assay developers. The time and cost saving of multiplexing is what...
Multiplex qPCR is a popular way of enhancing assays by combining multiple reactions in a single well. This approach can be extremely tempting, offering the...
Oligo synthesis and modifications Nucleic acid therapeutics
The core part of oligonucleotide therapeutics is the carefully refined sequence of nucleotides that precisely binds the intended target. However, beyond this,...
Although PCR remains the gold-standard technique for molecular diagnostics assays, PCR misses the mark for applications that require fast results or...
Molecular diagnostics NGS-based genotyping Nucleic acid extraction
Our scientists and product specialists work in close collaboration with a diverse range of customers to find solutions that meet their precise needs. Our...
Genomics Nucleic acid therapeutics
Dozens of oligonucleotide-based therapeutics are already on the market, helping to treat a range of life-threatening conditions. As we explored in our previous...
Genomics Nucleic acid therapeutics
With the rapid deployment of the mRNA COVID-19 vaccines and the recent approval of the first CRISPR gene therapy, the range of oligonucleotide-based...
Molecular diagnostics Disease detection
Although PCR is often viewed as a gold standard for molecular diagnostic tests, the problem of non-specific primer interactions can seriously limit its speed...
Molecular diagnostics Disease detection
Detecting single nucleotide variations (SNVs) offers powerful actionable insights in diagnosing diseases, monitoring cancer progression and identifyingpathogen...
Molecular diagnostics Disease detection
Since Humira (adalimumab) became the first approved monoclonal antibody therapy developed using phage display in 2002, it has sold more than any other drug in...
Molecular diagnostics Genomics
Image credit: HIV Reverse Transcriptase. RCSB Protein Data Bank. The Wellcome Collection.
Disease detection Nucleic acid therapeutics
While RNA-based therapeutics are taking the biotechnology world by storm following the rapid development of the COVID-19 vaccines, the next generation of...
Oligo synthesis and modifications Nucleic acid therapeutics
Considering bringing oligo synthesis in-house? Here are some commonly asked questions that we receive, grouped into four sections. You can jump to a section...
The recent Nobel Prize awarded to Katalin Karikó and Drew Weissman underlined the impact their breakthroughs in mRNA technology had in combating COVID-19....
Molecular diagnostics Disease detection
As the world scrambled to rapidly expand PCR testing capacity in 2020, it became increasingly clear that there was a need for cheaper, simpler, quicker...
Antimicrobial resistance (AMR) across bacterial species is developing rapidly, compounded by the improper use of antimicrobial agents that accelerates the...
Oligo synthesis and modifications Nucleic acid therapeutics
Updated : Fri, July 7, 2023
Over the last few decades, researchers have made impressive strides in developing methods to overcome the delivery, stability,...
Molecular diagnostics Nucleic acid extraction
Updated : Thu, June 29, 2023
Whether you’re working with samples for PCR or sequencing, it's worth questioning what type of extraction or purification...
Updated : Fri, May 26, 2023 @ 10:18 AM
Designing a new assay and scaling it for commercial use takes thoughtful planning, foresight, and engagement with...
Updated : Tue, May 9, 2023 @ 11:03 AM
When it comes to oligonucleotide therapeutics, the challenge has always been how to deliver an intact oligo to the right...
Molecular diagnostics Oligo synthesis and modifications qPCR General science
Updated : Fri, May 5, 2023 @ 2:34 PM
How does a BHQ dye contribute to producing superior data from your assays?
Oligo synthesis and modifications Nucleic acid therapeutics
Updated : Mon, June 26, 2023 @ 10:24 AM
Oligonucleotide therapeutics have unlocked new treatment possibilities for rare and fatal diseases often associated...
Molecular diagnostics SARS-CoV-2 Disease detection
Updated : Tue, May 9, 2023 @ 10:57 AM
We were delighted to attend the Association for Molecular Pathology (AMP) 2022 annual meeting, held in Phoenix, Arizona...
Molecular diagnostics Oligo synthesis and modifications
Updated : Tue, May 9, 2023 @ 11:01 AM
Originally developed in the early 1990s, aptamers have long been heralded as an antibody alternative for detection...
Molecular diagnostics Nucleic acid extraction General science
Updated : Tue, May 9, 2023 @ 11:05 AM
Molecular testing protocols for pathogen detection and diagnosing human diseases require reliable and high-quality...
Oligo synthesis and modifications Nucleic acid therapeutics General science
Updated : Tue, August 9, 2022 @ 7:10 PM
New approaches that use aptamers as targeting agents may open the door to wider clinical use in the future
Molecular diagnostics Oligo synthesis and modifications qPCR General science
Updated : Tue, May 9, 2023 @ 10:40 AM
Let the application be your guide when deciding between LNA, MGB and BHQplus
The many different chemistries available...
Molecular diagnostics Disease detection
Updated : Thu, July 7, 2022
Since 13 May 2022, reports of monkeypox cases began to appear globally in regions not endemic to the monkeypox virus.1 As the...
SARS-CoV-2 Nucleic acid extraction Disease detection General science
Updated : Fri, December 16, 2022 @ 3:39 PM
Since early 2020, diagnostic laboratories have had to manage patient sample quantities being in a state of flux....
Updated : Tue, March 21, 2023 @ 3:23 PM
What’s changed for clinical labs as we enter the third year of COVID-19 testing?
COVID-19, the illness caused by...
Molecular diagnostics qPCR General science
Updated : Wed, March 30, 2022 @ 4:00 PM
While both centralised and decentralised molecular diagnostics (MDx) testing models play an important role in patient...
Oligo synthesis and modifications Nucleic acid therapeutics
Updated : Tue, March 21, 2023 @ 3:46 PM
This is the second blog in a two-part series exploring how oligonucleotide modifications can support the advancement of...
Molecular diagnostics qPCR General science
Updated : Fri, April 15, 2022 @ 8:58 PM
The COVID-19 pandemic has accelerated the uptake of point of care testing (POCT), with simple, user-administered tests...
Oligo synthesis and modifications Nucleic acid therapeutics
Updated : Tue, March 21, 2023 @ 3:44 PM
This is the first blog post in a two-part series exploring how oligonucleotide modifications can support the...
qPCR SARS-CoV-2 General science
Updated : Fri, February 11, 2022 @ 10:58 PM
But measurement science could help steer us in a better, more informed direction
COVID-19 tests can indicate the...
Updated : Tue, January 11, 2022 @ 6:00 PM
What’s changed for clinical labs as we enter the third year of COVID-19 testing?
COVID-19, the illness caused by...
Updated : Tue, December 28, 2021 @ 3:30 PM
What’s changed for clinical labs as we enter the third year of COVID-19 testing?
COVID-19, the illness caused by...
Molecular diagnostics SARS-CoV-2
Updated : Wed, March 22, 2023 @ 2:01 PM
The emergence of the Omicron lineage has quickly escalated to be a variant of concern by the World Health Organization -
Updated : Thu, March 9, 2023 @ 5:39 PM
What’s changed for clinical labs as we enter the third year of COVID-19 testing?
Molecular diagnostics SARS-CoV-2
Updated : Fri, December 10, 2021 @ 2:34 AM
On 22 November 2021, The Network for Genomics Surveillance in South Africa detected a new SARS-CoV-2 variant, named...
| We're excited to announce that the proposal to extend certain key provisions of the In Vitro Diagnostic Regulation (IVDR) (EU) 2017/746 has been adopted... |
Molecular diagnostics SARS-CoV-2 Disease detection
Updated : Tue, November 30, 2021 @ 10:29 PM
A fourth wave of COVID-19 has already emerged in many countries and a newly classified variant of concern, Omicron...
Molecular diagnostics Oligo synthesis and modifications
Updated : Tue, January 25, 2022 @ 10:23 PM
This is the first blog post in a two-part series highlighting how Black Hole Quencher™ dyes can be incorporated into...
Molecular diagnostics SARS-CoV-2
Updated : Thu, October 14, 2021 @ 10:01 PM
SARS-CoV-2 mutations and associated new variants are being reported regularly in the media and scientific...
Molecular diagnostics qPCR SARS-CoV-2 General science
Updated : Thu, March 31, 2022 @ 3:24 PM
In September 2021, Delta persists as the most prevalent variant worldwide1 due to its high infectivity, causing surges...
Updated : Wed, September 15, 2021 @ 4:40 AM
A shortcut to understanding how to prepare for IVDR
In today’s global environment, even small regulatory changes in...
Molecular diagnostics SARS-CoV-2
Updated : Wed, November 9, 2022 @ 8:20 PM
The COVID-19 pandemic brought tremendous change to the molecular diagnostics (MDx) industry, delivering opportunities...
Updated : Thu, September 29, 2022 @ 7:57 PM
As SARS-CoV-2 variants continue to threaten public health, officials are looking beyond clinical tests to track...
Updated : Thu, December 16, 2021 @ 6:46 PM
Emerging SARS-CoV-2 variants of concern and variants of interest are defined by agencies such as the World Health...
Molecular diagnostics Genomics SARS-CoV-2 General science
Updated : Thu, March 9, 2023 @ 5:37 PM
As the global population gains greater access to vaccines for COVID-19, scientists and health officials continue to...
Molecular diagnostics SARS-CoV-2
Updated : Thu, March 9, 2023 @ 5:34 PM
Researchers have identified several variants of SARS-CoV-2 since they sequenced the original viral strain responsible...
Molecular diagnostics Genomics SARS-CoV-2 General science
Updated : Thu, February 3, 2022 @ 4:39 PM
Clinical and diagnostic labs worldwide are still experiencing supply chain challenges with their SARS-CoV-2 testing...
Molecular diagnostics Genomics SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:45 PM
Following up with the panelists from our recent COVID-19 webinar, Part 3 of 3
In the previous two blog posts in this...
Molecular diagnostics Genomics SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:42 PM
Following up with the panelists from our recent COVID-19 webinar, Part 2 of 3
In the face of a rapidly evolving...
Molecular diagnostics Genomics SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:45 PM
Following up with the panelists from our recent COVID-19 webinar, Part 1 of 3
The COVID-19 pandemic has presented...
Molecular diagnostics Genomics qPCR SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:44 PM
As countries worldwide begin to ease lockdown restrictions during the pandemic and prepare to return to “normal”...
Molecular diagnostics Genomics qPCR SARS-CoV-2
Updated : Fri, December 18, 2020 @ 8:49 PM
It may seem strange that a company known for transforming the global seed breeding industry is uniquely positioned...
Molecular diagnostics Oligo synthesis and modifications Genomics SARS-CoV-2 General science
Updated : Wed, March 22, 2023 @ 1:52 PM
We’re not rejecting you, just your oligo
PCR is arguably one of the most enabling technologies of modern molecular...
Molecular diagnostics SARS-CoV-2
Updated : Wed, November 25, 2020 @ 8:23 PM
On March 25, 2020, the US Food and Drug Administration (FDA) held the first of a series of virtual town halls they...
Molecular diagnostics Oligo synthesis and modifications Genomics SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:44 PM
In the nearly three months since the first confirmed case of COVID-19, the outbreak has become a global crisis, with...
Molecular diagnostics Genomics SARS-CoV-2 General science
Updated : Tue, March 21, 2023 @ 3:41 PM
*Since the original publication of this blog, LGC Biosearch Technologies is now the only acceptable commercial supplier...
Molecular diagnostics Genomics SARS-CoV-2
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Molecular diagnostics Next generation sequencing (NGS)
Updated : Tue, October 11, 2022 @ 8:43 PM
The development of new genomic sequencing techniques and bioinformatics analysis in the last decade has led to...
Genomics PCR-based genotyping Disease detection General science
Updated : Mon, September 19, 2022 @ 2:14 PM
3.2 billion people across 106 countries and territories, live in areas at risk of malaria transmission. The serious...
RNA FISH Disease detection General science
Updated : Mon, March 6, 2017 @ 4:37 PM
New research has, for the first time, found evidence suggesting the molecular epidemiology of how the Zika virus spreads...
Molecular diagnostics Oligo synthesis and modifications qPCR General science
Updated : Wed, December 14, 2022 @ 5:04 PM
OLIGO SYNTHESIS PHOTO GLIMPSE
We’ve recently captured our talented manufacturing teams hard at work building...
Molecular diagnostics qPCR General science
Updated : Mon, September 19, 2022 @ 2:13 PM
The largest recorded Ebola Virus Disease outbreak in history continues to devastate the West African region. This...
Molecular diagnostics qPCR General science
Updated : Wed, October 1, 2014 @ 4:51 PM
Non-squamous, Non-small cell lung cancer (NSCLC), the most common cause of death in the US and globally, has recently...
Updated : Mon, September 19, 2022 @ 2:07 PM
Biosearch Technologies is proud to sponsor the first IVD Technology Virtual Conference and Tradeshow. This free...
Updated : Wed, October 1, 2014 @ 4:42 PM
It can be difficult to transition a product from research to commercialization. It’s simply not feasible to conduct...
Agrigenomics Nucleic acid extraction
Rapid DNA purification kit reduces the seed genotyping workflow by almost a week
For many labs, the ability to deliver pure, high-quality DNA in just five...
Agrigenomics Next generation sequencing (NGS) Targeted GBS
By Dusty Vyas, Senior Scientist at LGC Biosearch Technologies
Agrigenomics Next generation sequencing (NGS) Targeted GBS
Environmental DNA (eDNA) is genetic material extracted from the environment from the likes of water, soil, sediment, sand,snowand ice where there is no sign of...
Agrigenomics Next generation sequencing (NGS) Targeted GBS
By Austin Sheppe PhD, LGC Biosearch Technologies withcontributionsby Dusty Vyas, Senior Scientist LGC Biosearch Technologies.
Molecular diagnostics NGS-based genotyping Nucleic acid extraction
Our scientists and product specialists work in close collaboration with a diverse range of customers to find solutions that meet their precise needs. Our...
African forest elephants are considered a keystone species due to their positive impact on the forest ecosystem. As the largest frugivores on earth, they have...
qPCR PCR-based genotyping oligos probes and primers
Need high specificity and shorter probes for your hybridisation assays? If you are considering Minor Groove Binder (MGB) Probes for your applications, here are...
Sorghum[Sorghum bicolor (L.) Moench] is a diploid cereal crop used for food, drink (beer), livestock feed, fuel and as an environmentally friendly building...
Oligo synthesis and modifications qPCR NGS-based genotyping KASP CPG
Our scientists can’t agree!
Our portfolio covers a wide range of products supporting research, development and manufacturing across the life sciences,...
Creating a crop that is more effective at meeting the needs of farmers and end consumers is the aim of every plant breeder. Using a targeted genotyping by...
Agrigenomics Next generation sequencing (NGS) NGS-based genotyping
Potato (Solanum tuberosum) is the world’s third most important food crop after wheat and cereal and is a staple food for over 1.3 billion people. The overall...
Agrigenomics Next generation sequencing (NGS) NGS-based genotyping
How does genomic selection increase profitability?
Livestock farmers’ and breeders’ profitability is directly related to the quality of their stock. But this...
Agrigenomics NGS-based genotyping
Every year over 1.5 million tonnes of blueberries and over half a million tonnes of cranberries are produced. This is expected to rise significantly over the...
Updated : Thu, June 1, 2023 @ 4:09 PM
Oil palm, Elaeis guineensis Jacq., is the most productive oil crop in the world1 supplying around 40% of all globally...
Agrigenomics PCR-based genotyping
Updated : Tue, May 9, 2023 @ 10:48 AM
Around 159,200 tonnes of strawberries are produced annually in Japan across 5,020 ha in various regions around the...
Agrigenomics PCR-based genotyping
Updated : Wed, March 22, 2023 @ 1:48 PM
Genotyping plants can be a complex and frustrating process
Agrigenomics PCR-based genotyping
Updated : Wed, March 22, 2023 @ 1:22 PM
Modern agriculture faces unprecedented challenges: increasing global temperatures, water scarcity, less arable land to...
Updated : Mon, April 17, 2023 @ 1:33 PM
This is the first blog in a two-part series exploring solutions for infectious diseases in aquaculture. This blog post...
Agrigenomics qPCR PCR-based genotyping General science
Updated : Wed, March 9, 2022 @ 1:05 AM
African oil palm (Elaeis guineensis Jacq.) is a highly productive perennial crop that is used widely in food, medicines,...
Agrigenomics qPCR PCR-based genotyping
Updated : Thu, January 12, 2023 @ 5:10 PM
Rice is the primary staple for more than half the world's population.1 With so many people relying on the crop for...
Agrigenomics Next generation sequencing (NGS) NGS-based genotyping
Updated : Tue, December 7, 2021 @ 10:11 PM
The decisions made by molecular breeding programmes have a substantial impact on the world around us, from...
Agrigenomics NGS-based genotyping
Updated : Fri, June 30, 2023 @ 2:19 PM
Many cultivated crops with agronomic significance, including wheat, peanut, oat, banana, potato, coffee, blueberry and...
Agrigenomics PCR-based genotyping Nucleic acid extraction
Updated : Tue, September 7, 2021 @ 7:59 PM
Aquaculture breeding programmes adopt genomic technologies, including genotyping, to increase genetic gain for...
Agrigenomics Next generation sequencing (NGS) Nucleic acid extraction
Updated : Thu, August 12, 2021 @ 11:51 PM
Informed plant breeding decisions help drive the field of agrigenomics towards ever-increasing agricultural...
Agrigenomics Nucleic acid extraction
Updated : Wed, August 4, 2021 @ 9:34 PM
A common mistake when initiating an agrigenomics project is failing to consider specific sample composition before...
Agrigenomics Genomics General science
Updated : Wed, December 14, 2022 @ 1:44 PM
The global demand for fish and fish products continues to increase as consumers focus on health-conscious ways to...
Agrigenomics Genomics NGS-based genotyping
Updated : Fri, November 20, 2020 @ 5:16 PM
In breeding programmes, selections based on a single or small number of markers to target traits in marker assisted...
Updated : Wed, October 7, 2020 @ 4:33 PM
“In July of 2015, I was a member of the radish genome project team. My task was to examine genetic diversity of radish...
Agrigenomics Genomics PCR-based genotyping
Updated : Fri, September 11, 2020 @ 9:52 PM
Darshna "Dusty" Vyas has been a Senior Scientist at LGC specialising in plant genetics for the past 8 years Her...
Agrigenomics Genomics PCR-based genotyping
Updated : Tue, July 14, 2020 @ 1:30 PM
Brassica rapa crops are important sources of food, feed, and fuel in many parts of the world and provide a unique...
Genomics Next generation sequencing (NGS) NGS-based genotyping
Updated : Wed, April 1, 2020 @ 8:12 PM
Back in September 2018, LGC acquired Lucigen Corporation. The ISO accredited site is based in Middleton, Wisconsin and...
Genomics PCR-based genotyping NGS-based genotyping
Updated : Mon, January 13, 2020 @ 5:08 PM
Best practice in sample collection for SeqSNP targeted genotyping by sequencing projects
When good goes in, great...
Agrigenomics Genomics Next generation sequencing (NGS) NGS-based genotyping
Updated : Wed, May 1, 2019 @ 3:59 PM
Livestock supports the livelihoods and food security of almost 1.3 billion people worldwide, contributing 40% of the...
Agrigenomics PCR-based genotyping Next generation sequencing (NGS) NGS-based genotyping
Updated : Fri, May 19, 2023 @ 8:53 AM
“Experience of artificial fertilisation, such as is effected with ornamental plants in order to obtain new variations in...
Agrigenomics Next generation sequencing (NGS) NGS-based genotyping
Updated : Thu, May 25, 2023 @ 11:32 AM
Plant and animal breeding programmes often take generations to improve quality and yield but using a genotyping protocol...
Updated : Wed, January 9, 2019 @ 5:03 PM
Genomic selection: 6 factors to consider when choosing between targeted GBS and microarrays
Agrigenomics Next generation sequencing (NGS) NGS-based genotyping
Updated : Tue, December 11, 2018 @ 4:32 PM
Food security is a major global threat and traditional methods of plant and animal breeding will not be sufficient...
Updated : Thu, July 26, 2018 @ 4:41 PM
Diversity is the spice of life and is also key to breeding rice that delivers increased yields. Rice is a crucial staple...
Agrigenomics Genomics PCR-based genotyping
Updated : Wed, November 22, 2017 @ 1:44 PM
Wheat is one of the three most important crops for human and livestock feed. With an ever-increasing global...
Agrigenomics Genomics PCR-based genotyping
Updated : Tue, July 10, 2018 @ 9:08 PM
Our world population is growing at a tremendous rate and by 2050, Africa’s population alone is set to hit over 2.5...
Genomics PCR-based genotyping Disease detection General science
Updated : Mon, September 19, 2022 @ 2:14 PM
3.2 billion people across 106 countries and territories, live in areas at risk of malaria transmission. The serious...
Genomics PCR-based genotyping General science
Updated : Wed, February 15, 2017 @ 4:23 PM
Demand for maize is increasing due to an increased number of people transitioning to meat-based diets driving demand...
Agrigenomics Genomics PCR-based genotyping NGS-based genotyping General science
Updated : Wed, January 18, 2017 @ 2:13 PM
Many areas critical to improved agricultural production require robust and scalable genotyping platforms to enable...
Updated : Mon, January 9, 2017 @ 3:20 PM
Screen more markers faster and bring crops with superior traits to the market quicker.
Updated : Tue, June 28, 2016 @ 9:00 PM
Modern breeding methods rely on the identification and utilization of molecular markers associated with traits...
qPCR PCR-based genotyping General science
Updated : Mon, September 19, 2022 @ 2:12 PM
Single Nucleotide Polymorphisms (SNPs) have been widely studied for over 15 years, and have applications in...
Oligo synthesis and modifications Nucleic acid therapeutics
The success of a nucleic acid therapeutic is highly dependent on the modifications made to the nucleotides. These mods play a key role in providing the...
In April 2025, the MIQE guidelines for quantitative real-time PCR (qPCR) were updated for the first time since their initial release in 2009. This latest...
Agrigenomics Nucleic acid extraction
Rapid DNA purification kit reduces the seed genotyping workflow by almost a week
For many labs, the ability to deliver pure, high-quality DNA in just five...
Getting multiple qPCR results at the same time in the same well is extremely valuable for assay developers. The time and cost saving of multiplexing is what...
Multiplex qPCR is a popular way of enhancing assays by combining multiple reactions in a single well. This approach can be extremely tempting, offering the...
Oligo synthesis and modifications Nucleic acid therapeutics
The core part of oligonucleotide therapeutics is the carefully refined sequence of nucleotides that precisely binds the intended target. However, beyond this,...
Oligo synthesis and modifications
An amino linker is perhaps the most versatile of all the modifications you can add to an oligonucleotide. Its primary amino group can attach a wide range of ...
Oligo synthesis and modifications
Locked nucleic acids are an increasingly popular modification for tailoring and improving the performance of oligonucleotides in a variety of ways. As part of...
Oligo synthesis and modifications
In our latest ‘Know your oligo mod’ post, we look at the impact of 5-methyl deoxycytidine – a modified nucleoside that increases the stability of the duplex...
Molecular diagnostics NGS-based genotyping Nucleic acid extraction
Our scientists and product specialists work in close collaboration with a diverse range of customers to find solutions that meet their precise needs. Our...
Genomics Nucleic acid therapeutics
Dozens of oligonucleotide-based therapeutics are already on the market, helping to treat a range of life-threatening conditions. As we explored in our previous...
Genomics Nucleic acid therapeutics
With the rapid deployment of the mRNA COVID-19 vaccines and the recent approval of the first CRISPR gene therapy, the range of oligonucleotide-based...
qPCR PCR-based genotyping oligos probes and primers
Need high specificity and shorter probes for your hybridisation assays? If you are considering Minor Groove Binder (MGB) Probes for your applications, here are...
Oligo synthesis and modifications qPCR NGS-based genotyping KASP CPG
Our scientists can’t agree!
Our portfolio covers a wide range of products supporting research, development and manufacturing across the life sciences,...
Oligo synthesis and modifications
The "Know your oligo mod" series continues with a deep dive into the 2'-O-methoxyethyl (2'-MOE) modification, a majoradvance in oligonucleotide therapeutic...
Oligo synthesis and modifications
In this latest instalment of our 'Know Your Oligo Mod' blog series, we explore the benefits of high-performance ATTO fluorescent dyes for labelling...
Oligo synthesis and modifications
In November 2023, the UK became the first country in the world to approve a gene therapy based on CRISPR-Cas9 technology. This Nobel prize-winning technique...
Molecular diagnostics Genomics
Image credit: HIV Reverse Transcriptase. RCSB Protein Data Bank. The Wellcome Collection.
qPCR testing is usually the method of choice when high sensitivity and specificity are required. For instance, in diagnostic and forensic applications, qPCR...
Oligo synthesis and modifications Nucleic acid therapeutics
Considering bringing oligo synthesis in-house? Here are some commonly asked questions that we receive, grouped into four sections. You can jump to a section...
Oligo synthesis and modifications General science
Labelling, linking or modifying biomolecules used to be a laborious process, requiring customised complex synthetic pathways that yield little product....
Antimicrobial resistance (AMR) across bacterial species is developing rapidly, compounded by the improper use of antimicrobial agents that accelerates the...
Oligo synthesis and modifications Nucleic acid therapeutics
Updated : Fri, July 7, 2023
Over the last few decades, researchers have made impressive strides in developing methods to overcome the delivery, stability,...
Molecular diagnostics Nucleic acid extraction
Updated : Thu, June 29, 2023
Whether you’re working with samples for PCR or sequencing, it's worth questioning what type of extraction or purification...
Molecular diagnostics Oligo synthesis and modifications qPCR General science
Updated : Fri, May 5, 2023 @ 2:34 PM
How does a BHQ dye contribute to producing superior data from your assays?
Oligo synthesis and modifications Nucleic acid therapeutics
Updated : Mon, June 26, 2023 @ 10:24 AM
Oligonucleotide therapeutics have unlocked new treatment possibilities for rare and fatal diseases often associated...
Oligo synthesis and modifications General science
Updated : Tue, May 9, 2023 @ 10:51 AM
In the next edition of the “Know your oligo mod” series, we look at a universal base analogue for oligonucleotide...
Molecular diagnostics Oligo synthesis and modifications
Updated : Tue, May 9, 2023 @ 11:01 AM
Originally developed in the early 1990s, aptamers have long been heralded as an antibody alternative for detection...
Molecular diagnostics Nucleic acid extraction General science
Updated : Tue, May 9, 2023 @ 11:05 AM
Molecular testing protocols for pathogen detection and diagnosing human diseases require reliable and high-quality...
Updated : Wed, December 14, 2022 @ 1:54 PM
When the polymerase chain reaction (PCR) was first described, the Klenow fragment of Escherichia coli DNA...
Oligo synthesis and modifications Nucleic acid therapeutics General science
Updated : Tue, August 9, 2022 @ 7:10 PM
New approaches that use aptamers as targeting agents may open the door to wider clinical use in the future
Molecular diagnostics Oligo synthesis and modifications qPCR General science
Updated : Tue, May 9, 2023 @ 10:40 AM
Let the application be your guide when deciding between LNA, MGB and BHQplus
The many different chemistries available...
SARS-CoV-2 Nucleic acid extraction Disease detection General science
Updated : Fri, December 16, 2022 @ 3:39 PM
Since early 2020, diagnostic laboratories have had to manage patient sample quantities being in a state of flux....
Molecular diagnostics qPCR General science
Updated : Wed, March 30, 2022 @ 4:00 PM
While both centralised and decentralised molecular diagnostics (MDx) testing models play an important role in patient...
Oligo synthesis and modifications Nucleic acid therapeutics
Updated : Tue, March 21, 2023 @ 3:46 PM
This is the second blog in a two-part series exploring how oligonucleotide modifications can support the advancement of...
Agrigenomics qPCR PCR-based genotyping General science
Updated : Wed, March 9, 2022 @ 1:05 AM
African oil palm (Elaeis guineensis Jacq.) is a highly productive perennial crop that is used widely in food, medicines,...
Molecular diagnostics qPCR General science
Updated : Fri, April 15, 2022 @ 8:58 PM
The COVID-19 pandemic has accelerated the uptake of point of care testing (POCT), with simple, user-administered tests...
Oligo synthesis and modifications Nucleic acid therapeutics
Updated : Tue, March 21, 2023 @ 3:44 PM
This is the first blog post in a two-part series exploring how oligonucleotide modifications can support the...
qPCR SARS-CoV-2 General science
Updated : Fri, February 11, 2022 @ 10:58 PM
But measurement science could help steer us in a better, more informed direction
COVID-19 tests can indicate the...
Oligo synthesis and modifications
Updated : Tue, January 25, 2022 @ 8:30 PM
More innovative applications for Black Hole Quencher (BHQ) dyes
In imaging and detection assay development,...
Updated : Wed, March 22, 2023 @ 1:23 PM
Stellaris controls, who needs ‘em? We all do. Especially if it’s your first time interrogating a sample with a new...
Agrigenomics qPCR PCR-based genotyping
Updated : Thu, January 12, 2023 @ 5:10 PM
Rice is the primary staple for more than half the world's population.1 With so many people relying on the crop for...
Oligo synthesis and modifications General science
Updated : Wed, December 14, 2022 @ 4:45 PM
This is the final blog post in a three-part educational series about best practices for in-house oligonucleotide...
Molecular diagnostics Oligo synthesis and modifications
Updated : Tue, January 25, 2022 @ 10:23 PM
This is the first blog post in a two-part series highlighting how Black Hole Quencher™ dyes can be incorporated into...
Oligo synthesis and modifications General science
Updated : Wed, December 14, 2022 @ 4:43 PM
This is the second blog post in a three-part educational series about best practices for in-house oligonucleotide...
Updated : Thu, February 3, 2022 @ 6:10 PM
When results from your qPCR assays aren’t quite what you expected, it can be challenging to understand what went...
Molecular diagnostics qPCR SARS-CoV-2 General science
Updated : Thu, March 31, 2022 @ 3:24 PM
In September 2021, Delta persists as the most prevalent variant worldwide1 due to its high infectivity, causing surges...
Oligo synthesis and modifications General science
Updated : Wed, December 14, 2022 @ 4:43 PM
This is the first blog post in a three-part educational series about best practices for in-house oligonucleotide...
Agrigenomics PCR-based genotyping Nucleic acid extraction
Updated : Tue, September 7, 2021 @ 7:59 PM
Aquaculture breeding programmes adopt genomic technologies, including genotyping, to increase genetic gain for...
Agrigenomics Next generation sequencing (NGS) Nucleic acid extraction
Updated : Thu, August 12, 2021 @ 11:51 PM
Informed plant breeding decisions help drive the field of agrigenomics towards ever-increasing agricultural...
Agrigenomics Nucleic acid extraction
Updated : Wed, August 4, 2021 @ 9:34 PM
A common mistake when initiating an agrigenomics project is failing to consider specific sample composition before...
Agrigenomics Genomics General science
Updated : Wed, December 14, 2022 @ 1:44 PM
The global demand for fish and fish products continues to increase as consumers focus on health-conscious ways to...
Molecular diagnostics Genomics SARS-CoV-2 General science
Updated : Thu, March 9, 2023 @ 5:37 PM
As the global population gains greater access to vaccines for COVID-19, scientists and health officials continue to...
Agrigenomics Genomics NGS-based genotyping
Updated : Fri, November 20, 2020 @ 5:16 PM
In breeding programmes, selections based on a single or small number of markers to target traits in marker assisted...
Molecular diagnostics Genomics SARS-CoV-2 General science
Updated : Thu, February 3, 2022 @ 4:39 PM
Clinical and diagnostic labs worldwide are still experiencing supply chain challenges with their SARS-CoV-2 testing...
Updated : Wed, October 7, 2020 @ 4:33 PM
“In July of 2015, I was a member of the radish genome project team. My task was to examine genetic diversity of radish...
Agrigenomics Genomics PCR-based genotyping
Updated : Fri, September 11, 2020 @ 9:52 PM
Darshna "Dusty" Vyas has been a Senior Scientist at LGC specialising in plant genetics for the past 8 years Her...
Molecular diagnostics Genomics SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:45 PM
Following up with the panelists from our recent COVID-19 webinar, Part 3 of 3
In the previous two blog posts in this...
Molecular diagnostics Genomics SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:42 PM
Following up with the panelists from our recent COVID-19 webinar, Part 2 of 3
In the face of a rapidly evolving...
Molecular diagnostics Genomics SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:45 PM
Following up with the panelists from our recent COVID-19 webinar, Part 1 of 3
The COVID-19 pandemic has presented...
Molecular diagnostics Genomics qPCR SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:44 PM
As countries worldwide begin to ease lockdown restrictions during the pandemic and prepare to return to “normal”...
Agrigenomics Genomics PCR-based genotyping
Updated : Tue, July 14, 2020 @ 1:30 PM
Brassica rapa crops are important sources of food, feed, and fuel in many parts of the world and provide a unique...
Molecular diagnostics Genomics qPCR SARS-CoV-2
Updated : Fri, December 18, 2020 @ 8:49 PM
It may seem strange that a company known for transforming the global seed breeding industry is uniquely positioned...
Molecular diagnostics Oligo synthesis and modifications Genomics SARS-CoV-2 General science
Updated : Wed, March 22, 2023 @ 1:52 PM
We’re not rejecting you, just your oligo
PCR is arguably one of the most enabling technologies of modern molecular...
Genomics Next generation sequencing (NGS) NGS-based genotyping
Updated : Wed, April 1, 2020 @ 8:12 PM
Back in September 2018, LGC acquired Lucigen Corporation. The ISO accredited site is based in Middleton, Wisconsin and...
Molecular diagnostics Oligo synthesis and modifications Genomics SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:44 PM
In the nearly three months since the first confirmed case of COVID-19, the outbreak has become a global crisis, with...
Molecular diagnostics Genomics SARS-CoV-2 General science
Updated : Tue, March 21, 2023 @ 3:41 PM
*Since the original publication of this blog, LGC Biosearch Technologies is now the only acceptable commercial supplier...
Molecular diagnostics Genomics SARS-CoV-2
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Genomics PCR-based genotyping NGS-based genotyping
Updated : Mon, January 13, 2020 @ 5:08 PM
Best practice in sample collection for SeqSNP targeted genotyping by sequencing projects
When good goes in, great...
Agrigenomics Genomics Next generation sequencing (NGS) NGS-based genotyping
Updated : Wed, May 1, 2019 @ 3:59 PM
Livestock supports the livelihoods and food security of almost 1.3 billion people worldwide, contributing 40% of the...
Updated : Fri, March 29, 2019 @ 4:39 PM
We've heard it said for years, "TV will rot your brain". But in the case of our three colleagues below, that definitely...
Updated : Wed, January 9, 2019 @ 5:03 PM
Genomic selection: 6 factors to consider when choosing between targeted GBS and microarrays
Updated : Mon, September 19, 2022 @ 2:14 PM
While the science of pharmacogenomics has been around for years, its popularity is starting to pick up steam as...
Genomics Nucleic acid extraction
Updated : Thu, June 28, 2018 @ 4:28 PM
Imagine a time capsule the size of a shoebox that holds all the information currently on the internet that can be stored...
Updated : Tue, May 29, 2018 @ 3:47 PM
Ever wake up in the morning just feeling like a rock star, or maybe like Francis Crick, Rosalind Franklin or Maurice...
Updated : Mon, April 30, 2018 @ 1:53 PM
To truly understand complex diseases such as cancer, scientists need access to tools that don’t just average data...
Updated : Thu, March 29, 2018 @ 4:00 PM
Ask any little girl what they want to be when they grow up and you may hear things like, princess, ballerina, pop star,...
Updated : Tue, January 16, 2018 @ 4:50 PM
Stellaris® RNA FISH (fluorescence in situ hybridization) is an RNA visualization method that allows simultaneous...
Agrigenomics Genomics PCR-based genotyping
Updated : Wed, November 22, 2017 @ 1:44 PM
Wheat is one of the three most important crops for human and livestock feed. With an ever-increasing global...
Agrigenomics Genomics PCR-based genotyping
Updated : Tue, July 10, 2018 @ 9:08 PM
Our world population is growing at a tremendous rate and by 2050, Africa’s population alone is set to hit over 2.5...
Genomics PCR-based genotyping Disease detection General science
Updated : Mon, September 19, 2022 @ 2:14 PM
3.2 billion people across 106 countries and territories, live in areas at risk of malaria transmission. The serious...
RNA FISH Genomics General science
Updated : Thu, July 6, 2017 @ 3:22 PM
Recently LGC Genomics hosted a lunch and learn Stellaris® seminar at the Helen Diller Cancer Institute at UCSF with our...
Updated : Mon, September 19, 2022 @ 2:07 PM
LGC's Genomics Division has signed a memorandum of understanding (MOU) with Chinese health management expert...
RNA FISH Disease detection General science
Updated : Mon, March 6, 2017 @ 4:37 PM
New research has, for the first time, found evidence suggesting the molecular epidemiology of how the Zika virus spreads...
Genomics PCR-based genotyping General science
Updated : Wed, February 15, 2017 @ 4:23 PM
Demand for maize is increasing due to an increased number of people transitioning to meat-based diets driving demand...
Updated : Mon, September 19, 2022 @ 2:05 PM
The advent of and ongoing improvements to next-generation sequencing technologies is driving the continuing and...
Updated : Mon, January 23, 2017 @ 4:27 PM
Nature versus nurture. It’s a tale as old as time.
When Craig Venter made the comment after the human genome sequence...
Agrigenomics Genomics PCR-based genotyping NGS-based genotyping General science
Updated : Wed, January 18, 2017 @ 2:13 PM
Many areas critical to improved agricultural production require robust and scalable genotyping platforms to enable...
Updated : Mon, September 19, 2022 @ 2:15 PM
It seems everyone wants to do more with less, and automate the process as well. But this can cause a number of...
RNA FISH Genomics General science
Updated : Mon, September 19, 2022 @ 2:12 PM
It wouldn't be fair to close out 2016 without showcasing the stellar year that Stellaris® RNA FISH has had. Take a...
Updated : Mon, November 28, 2016 @ 11:31 PM
The secret of life. That’s what Francis Crick and James Watson claimed they had discovered back in Cambridge,...
Updated : Mon, November 21, 2016 @ 3:32 PM
In the early 1900s, scientists found that the function of genes was to make proteins, disproving the earlier idea...
Updated : Wed, March 29, 2023 @ 10:51 AM
The strands of DNA in your cells are organized into pieces called chromosomes. Chromosomes are further organized into...
Updated : Mon, September 19, 2022 @ 2:13 PM
Researchers from the Baker IDI Heart and Diabetes Institute in Melbourne, Australia have blamed a default...
Updated : Wed, March 29, 2023 @ 11:04 AM
As the Zika virus outbreak spreads, a wave of international concern has grown, and scientists have scrambled to...
Oligo synthesis and modifications General science
Updated : Wed, March 29, 2023 @ 10:55 AM
Thio C6 Linker (Thiohexyl)
We continue our “Know Your Oligo Mod” series with another versatile custom oligonucleotide...
Molecular diagnostics Oligo synthesis and modifications qPCR General science
Updated : Wed, December 14, 2022 @ 5:04 PM
OLIGO SYNTHESIS PHOTO GLIMPSE
We’ve recently captured our talented manufacturing teams hard at work building...