The BiosearchTech Blog

Robust supply chains and open testing systems: How our AgBio roots enable solutions to the COVID-19 pandemic

Posted on Tue, May 19, 2020 @ 08:18 AM

It may seem strange that a company known for transforming the global seed breeding industry is uniquely positioned to help COVID-19 testing labs overcome bottlenecks and rapidly scale-up testing. However, when you look at the problems testing labs are facing, it becomes clear that LGC, Biosearch Technologies has all the right tools for a rapid and robust pandemic response, even with the need to validate our Research Use Only (RUO) products for diagnostic testing. Today’s significantly altered conditions require new approaches and new solutions.

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Topics: Genomics, qPCR, Coronavirus

Behind the scenes: How our oligo synthesis team contributes to the reliability of your assays

Posted on Thu, Apr 30, 2020 @ 02:13 PM

We’re not rejecting you, just your oligo

PCR is arguably one of the most enabling technologies of modern molecular biology, with a sensitivity that can detect incredibly small amounts of DNA. However, the sensitivity of the method is also one of the biggest challenges—when you can detect just a few molecules of DNA, inadvertent contamination can give you misleading data. Issues with contamination are especially critical in qPCR reactions for molecular diagnostics testing, such as for SARS-CoV-2 detection, where any contaminating template DNA, even if it’s just long fragments, can generate false positive results.

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Topics: Genomics, Coronavirus, Oligo synthesis

Expanded SeqSNP support with new NGS lab in Middleton, WI

Posted on Tue, Apr 14, 2020 @ 09:15 AM

LGC, Biosearch Technologies is excited to announce the expansion of SeqSNP targeted genotyping by sequencing (GBS) services in North America. Advancing AgBio projects from our Middleton, Wisconsin, USA, location, these services provide an all-inclusive, cost-effective targeted GBS solution that requires no setup costs or upfront sample number commitment.

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Topics: Agrigenomics, Genomics, GBS, SeqSNP, Genotyping by Sequencing (GBS), Targeted Genotyping by Sequencing

When you don’t need an EUA for SARS-CoV-2 testing

Posted on Fri, Apr 10, 2020 @ 03:00 PM

On March 25, 2020, the US Food and Drug Administration (FDA) held the first of a series of virtual town halls they will be holding to answer technical questions about developing, validating, and implementing tests to detect SARS-CoV-2. Elizabeth Hillebrenner and Timothy Stenzel, PhD, from the Center for Devices and Radiological Health (CDRH) provided an overview of the policies governing the development and deployment of SARS-CoV-2 tests as well as expanded guidance on the existing policies. One of the more interesting points they covered were the different scenarios where diagnostic test developers do not need to file for an emergency use authorisation (EUA), which the FDA put in place to expedite increased testing capabilities. We’ve summarised those scenarios here, although we recommend you use the links at the end of this post to see the source material from the FDA if you are considering any of these pathways.

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Topics: Coronavirus

New NGS service lab now open in Middleton, WI for expanded global support

Posted on Wed, Apr 01, 2020 @ 09:27 AM

Back in September 2018, LGC acquired Lucigen Corporation. The ISO accredited site is based in Middleton, Wisconsin and employs just over 75 people. Lucigen specialises in enzymes, competent cells, and cloning systems to support applications in diagnostics, drug discovery, synthetic biology and gene editing, and now as a part of the Biosearch Technologies portfolio, is expanding next generation sequencing (NGS) services in support of our agricultural biotechnology customers.

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Topics: Genomics, Targeted Genotyping, Next Generation Sequencing (NGS)

Addressing COVID-19 together: LGC, Biosearch Technologies and Shanghai Liferiver Biotechnology Co., Ltd.

Posted on Tue, Mar 31, 2020 @ 10:13 AM

In the nearly three months since the first confirmed case of COVID-19, the outbreak has become a global crisis, with the World Health Organization (WHO) reporting 113,702 confirmed cases of COVID-19 as of March 10, 2020, with 80,924 of those cases in China and the remaining 32,778 cases spread across 109 countries1.

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Topics: Custom Oligos, Genomics, Coronavirus

What diagnostic test makers and CLIA labs in the US need to know about Emergency Use Authorization (EUA)

Posted on Tue, Mar 24, 2020 @ 11:58 AM

As the COVID-19 pandemic challenges society with the largest public health crisis of modern times, testing is a crucial part of the response. In the United States (U.S.), getting tests into the community has been challenging, in part due to the need to obtain an Emergency Use Authorization (EUA) from the U.S. Food and Drug Administration (FDA); however, in recent weeks, the US government has been doing its best to partner with private industry where the FDA has been fast-tracking more EUAs in effort to making testing more widely available across the country.

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Topics: Genomics, Coronavirus

Coronavirus outbreak: Collaboration to meet the challenge

Posted on Mon, Mar 16, 2020 @ 12:30 PM

Petaluma video clip for coronavirus landing page 1-1

Coronavirus, or COVID-19, is an infectious virus that is spreading rapidly around the world and the World Health Organisation (WHO) declared the outbreak a global health emergency within weeks of its identification. As of 11 March, WHO announced that the Coronavirus outbreak has become a global pandemic.

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Topics: Genomics, Coronavirus

Molecular diagnostics: how can NGS live up to its promises?

Posted on Wed, Jan 29, 2020 @ 09:37 AM

The development of new genomic sequencing techniques and bioinformatics analysis in the last decade has led to massive advances in the diagnosis, prognosis and treatment of disease (1,2).

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Topics: Molecular Diagnostics, Genomics, Genotyping, Next Generation Sequencing (NGS)

Back to basics - the crucial step of sample collection

Posted on Wed, Jan 15, 2020 @ 09:37 AM

Best practice in sample collection for SeqSNP targeted genotyping by sequencing projects

When good goes in, great comes out

Great genotyping data begins with good sample collection. Sampling can be tedious work, so we’re providing tips on proper collection to lock down efficiency and ensure the best outcome.

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Topics: Genomics, Genotyping, Sequencing, SeqSNP

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About Biosearch Technologies

As the inventor of the BHQ dyes, Biosearch Technologies synthesizes sophisticated oligos for real time qPCR, molecular diagnostics, and more!  Visit our home page to view our products and services.

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