How to select an effective nucleic acid isolation method for human diagnostics

How to select an effective nucleic acid isolation method for human diagnostics

Molecular testing protocols for pathogen detection and diagnosing human diseases require reliable and high-quality isolation of genetic material from diverse sample types. There are many extraction and purification technologies available. Before deciding which isolation method best suits your application, read this blog that walks you through key considerations...

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Why genome-editing CRISPR/Cas offers hope for accelerated sustainable crop improvement in oil palm

Posted on Thu, Jun 01, 2023 @ 11:09 AM

Oil palm, Elaeis guineensis Jacq., is the most productive oil crop in the world1 supplying around 40% of all globally ...
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Topics: Agrigenomics

Mastering assay scale-up: 4 tips to help avoid the most common mistakes

Posted on Thu, May 25, 2023 @ 10:19 AM

Designing a new assay and scaling it for commercial use takes thoughtful planning, foresight, and engagement with ...
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Topics: Molecular diagnostics, Human healthcare

A knack for getting to the liver: GalNAc enables liver-targeted oligonucleotide therapeutics

Posted on Wed, May 24, 2023 @ 10:06 AM

When it comes to oligonucleotide therapeutics, the challenge has always been how to deliver an intact oligo to the ...
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Topics: Nucleic acid therapeutics, Human healthcare

A way to simplify design and interpretation of your qPCR assays

Posted on Fri, May 05, 2023 @ 09:34 AM

How does a BHQ dye contribute to producing superior data from your assays?
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Topics: Molecular diagnostics, Oligo synthesis and modifications, qPCR, Human healthcare, General science

Which controlled pore glass is right for your therapeutic application?

Posted on Fri, Mar 31, 2023 @ 10:48 AM

Oligonucleotide therapeutics have unlocked new treatment possibilities for rare and fatal diseases often associated ...
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Topics: Oligo synthesis and modifications, Nucleic acid therapeutics, Human healthcare

Enhancing strawberry breeding with predictive models, marker-assisted selection and genotyping automation

Posted on Wed, Mar 08, 2023 @ 06:09 AM

Around 159,200 tonnes of strawberries are produced annually in Japan across 5,020 ha in various regions around the ...
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Topics: Agrigenomics, PCR-based genotyping, Applied agrigenomics

5-Nitroindole – a universal base oligo modification

Posted on Thu, Feb 16, 2023 @ 09:27 AM

In the next edition of the “Know your oligo mod” series, we look at a universal base analogue for oligonucleotide ...
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Topics: Oligo synthesis and modifications, Human healthcare, General science

Celebrating the women of LGC 2023

Posted on Fri, Feb 10, 2023 @ 04:13 AM

This International Day of Women and Girls in Science (11 February) LGC Biosearch Technologies celebrates female ...
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How MGB probes could solve your complex plant genome genotyping issues

Posted on Thu, Jan 26, 2023 @ 01:34 PM

Genotyping plants can be a complex and frustrating process
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Topics: Agrigenomics, PCR-based genotyping, Applied agrigenomics

AMP conference 2022: Developing a 5-minute point-of-care PCR test

Posted on Wed, Jan 11, 2023 @ 08:15 AM

We were delighted to attend the Association for Molecular Pathology (AMP) 2022 annual meeting, held in Phoenix, Arizona ...
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Topics: Molecular diagnostics, SARS-CoV-2, Disease detection, Human healthcare

What’s next for aptamers in diagnostics?

Posted on Thu, Nov 10, 2022 @ 08:17 AM

Originally developed in the early 1990s, aptamers have long been heralded as an antibody alternative for detection ...
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Topics: Molecular diagnostics, Oligo synthesis and modifications, Human healthcare

How to select an effective nucleic acid isolation method for human diagnostics?

Posted on Tue, Oct 18, 2022 @ 10:19 AM

Molecular testing protocols for pathogen detection and diagnosing human diseases require reliable and high-quality ...
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Topics: Molecular diagnostics, Nucleic acid extraction, Human healthcare, Applied agrigenomics, General science

Explore the vast applications of KASP genotyping for plant breeding programmes

Posted on Tue, Sep 20, 2022 @ 06:45 AM

Modern agriculture faces unprecedented challenges: increasing global temperatures, water scarcity, less arable land to ...
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Topics: Agrigenomics, PCR-based genotyping, Applied agrigenomics

Taq Polymerase: What is it and its applications

Posted on Fri, Aug 26, 2022 @ 07:58 AM

When the polymerase chain reaction (PCR) was first described, the Klenow fragment of Escherichia coli DNA Polymerase I ...
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Topics: qPCR, General science

Where are all the therapeutic aptamers?

Posted on Tue, Aug 09, 2022 @ 02:10 PM

New approaches that use aptamers as targeting agents may open the door to wider clinical use in the future
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Topics: Oligo synthesis and modifications, Nucleic acid therapeutics, General science

Choosing the best qPCR probe chemistry for your assay

Posted on Thu, Jul 28, 2022 @ 10:15 AM

Let the application be your guide when deciding between LNA, MGB and BHQplus  The many different chemistries available ...
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Topics: Molecular diagnostics, Oligo synthesis and modifications, qPCR, Human healthcare, General science

Pivoting to monkeypox diagnostics

Posted on Thu, Jul 07, 2022 @ 05:38 PM

Since 13 May 2022, reports of monkeypox cases began to appear globally in regions not endemic to the monkeypox virus.1 ...
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Topics: Molecular diagnostics, Disease detection, Human healthcare

Genetic solutions to infectious diseases in aquaculture

Posted on Thu, Jun 30, 2022 @ 04:12 PM

This is the second blog in a two-part series exploring solutions for infectious diseases in aquaculture. In the first ...
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Topics: Agrigenomics, PCR-based genotyping, NGS-based genotyping, Applied agrigenomics

Make your diagnostic workflows more adaptable

Posted on Mon, Jun 06, 2022 @ 02:47 PM

Since early 2020, diagnostic laboratories have had to manage patient sample quantities being in a state of flux. Demand ...
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Topics: SARS-CoV-2, Nucleic acid extraction, Disease detection, Human healthcare, Applied agrigenomics, General science

Increasing resistance to aquaculture disease

Posted on Tue, Apr 19, 2022 @ 11:00 AM

This is the first blog in a two-part series exploring solutions for infectious diseases in aquaculture. This blog post ...
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Topics: Agrigenomics, Applied agrigenomics

Pandemic reflections: Adapting to testing priorities

Posted on Tue, Apr 05, 2022 @ 04:55 PM

What’s changed for clinical labs as we enter the third year of COVID-19 testing? COVID-19, the illness caused by ...
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Topics: SARS-CoV-2, Human healthcare

Optimising automated high-throughput pathogen detection workflows

Posted on Wed, Mar 30, 2022 @ 11:00 AM

While both centralised and decentralised molecular diagnostics (MDx) testing models play an important role in patient ...
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Topics: Molecular diagnostics, qPCR, Human healthcare, General science

Overcoming manufacturing challenges associated with nucleic acid therapeutics

Posted on Thu, Mar 24, 2022 @ 06:15 PM

This is the second blog in a two-part series exploring how oligonucleotide modifications can support the advancement of ...
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Topics: Oligo synthesis and modifications, Nucleic acid therapeutics, Human healthcare

Improving the sustainability of oil palm breeding programmes using marker-assisted selection

Posted on Tue, Mar 08, 2022 @ 03:00 PM

African oil palm (Elaeis guineensis Jacq.) is a highly productive perennial crop that is used widely in food, ...
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Topics: Agrigenomics, qPCR, PCR-based genotyping, Human healthcare, Applied agrigenomics, General science

Considerations for RT-qPCR in molecular point of care testing devices

Posted on Tue, Mar 01, 2022 @ 03:11 PM

The COVID-19 pandemic has accelerated the uptake of point of care testing (POCT), with simple, user-administered tests ...
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Topics: Molecular diagnostics, qPCR, Human healthcare, General science

Nucleic acid therapeutics for next-generation disease management

Posted on Fri, Feb 25, 2022 @ 02:47 PM

This is the first blog post in a two-part series exploring how oligonucleotide modifications can support the ...
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Topics: Oligo synthesis and modifications, Nucleic acid therapeutics, Human healthcare

Society can’t handle the caveats to each type of COVID-19 test

Posted on Fri, Feb 11, 2022 @ 04:58 PM

But measurement science could help steer us in a better, more informed direction COVID-19 tests can indicate the ...
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Topics: qPCR, SARS-CoV-2, Human healthcare, General science

Leveraging quenching efficiency of Black Hole Quencher dyes for PCR and beyond

Posted on Tue, Jan 25, 2022 @ 02:30 PM

More innovative applications for Black Hole Quencher (BHQ) dyes In imaging and detection assay development, innovative ...
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Topics: Oligo synthesis and modifications

Five ways controls can demystify your Stellaris™ RNA FISH experiment

Posted on Sun, Jan 23, 2022 @ 06:14 AM

Stellaris controls, who needs ‘em? We all do. Especially if it’s your first time interrogating a sample with a new ...
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Topics: RNA FISH, General science

Increasing hybrid rice breeding efficiency with high-throughput genotyping

Posted on Tue, Jan 18, 2022 @ 03:03 PM

Rice is the primary staple for more than half the world's population.1 With so many people relying on the crop for ...
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Topics: Agrigenomics, qPCR, PCR-based genotyping

Pandemic reflections: in the face of SARS-CoV-2 variants, COVID-19 testing remains essential

Posted on Tue, Jan 11, 2022 @ 12:00 PM

What’s changed for clinical labs as we enter the third year of COVID-19 testing? COVID-19, the illness caused by ...
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Topics: SARS-CoV-2

Pandemic reflections: unprecedented demand drives COVID-19 test developers to get creative

Posted on Tue, Dec 28, 2021 @ 09:30 AM

What’s changed for clinical labs as we enter the third year of COVID-19 testing? COVID-19, the illness caused by ...
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Topics: SARS-CoV-2

Technical bulletin: Omicron impact on SARS-CoV-2 mutation analysis and investigation

Posted on Thu, Dec 23, 2021 @ 11:45 AM

The emergence of the Omicron lineage has quickly escalated to be a variant of concern by the World Health Organization ...
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Topics: Molecular diagnostics, SARS-CoV-2, Human healthcare

Pandemic reflections: the world is short staffed

Posted on Tue, Dec 21, 2021 @ 06:52 PM

What’s changed for clinical labs as we enter the third year of COVID-19 testing?
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Topics: SARS-CoV-2, Human healthcare

Oligonucleotide synthesis basics: Key takeaways for post-synthesis processing

Posted on Thu, Dec 16, 2021 @ 04:39 PM

This is the final blog post in a three-part educational series about best practices for in-house oligonucleotide ...
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Topics: Oligo synthesis and modifications, Human healthcare, General science

Ensuring our diagnostic assays detect the Omicron variant

Posted on Thu, Dec 09, 2021 @ 04:24 PM

On 22 November 2021, The Network for Genomics Surveillance in South Africa detected a new SARS-CoV-2 variant, named the ...
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Topics: Molecular diagnostics, SARS-CoV-2

A targeted GBS technology for all breeding communities

Posted on Tue, Dec 07, 2021 @ 04:11 PM

The decisions made by molecular breeding programmes have a substantial impact on the world around us, from productivity ...
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Topics: Agrigenomics, Next generation sequencing (NGS), NGS-based genotyping

Extensions to the IVDR - what diagnostics manufacturers and suppliers need to know

Posted on Thu, Dec 02, 2021 @ 05:25 PM

We're excited to announce that the proposal to extend certain key provisions of the In Vitro Diagnostic Regulation ...
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Topics: Molecular diagnostics, Human healthcare

Streamlining diagnostic workflows for common respiratory diseases, such as SARS-CoV-2, influenza and RSV

Posted on Tue, Nov 30, 2021 @ 04:29 PM

A fourth wave of COVID-19 has already emerged in many countries and a newly classified variant of concern, Omicron ...
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Topics: Molecular diagnostics, SARS-CoV-2, Disease detection

NGS solutions for polyploid plant breeding challenges

Posted on Tue, Nov 23, 2021 @ 09:00 AM

Many cultivated crops with agronomic significance, including wheat, peanut, oat, banana, potato, coffee, blueberry ...
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Topics: Agrigenomics, NGS-based genotyping, Applied agrigenomics

Innovative applications for Black Hole Quencher dyes

Posted on Tue, Nov 16, 2021 @ 04:14 PM

This is the first blog post in a two-part series highlighting how Black Hole Quencher™ dyes can be incorporated into ...
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Topics: Molecular diagnostics, Oligo synthesis and modifications

Oligonucleotide synthesis basics: 4 key takeaways for in-house oligo production

Posted on Tue, Nov 02, 2021 @ 11:41 AM

This is the second blog post in a three-part educational series about best practices for in-house oligonucleotide ...
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Topics: Oligo synthesis and modifications, General science

Technical bulletin: SARS-CoV-2 mutation analysis and investigation

Posted on Thu, Oct 14, 2021 @ 05:01 PM

SARS-CoV-2 mutations and associated new variants are being reported regularly in the media and scientific literature. ...
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Topics: Molecular diagnostics, SARS-CoV-2

8 qPCR amplification plot questions answered

Posted on Thu, Sep 30, 2021 @ 10:00 AM

When results from your qPCR assays aren’t quite what you expected, it can be challenging to understand what went wrong. ...
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Topics: qPCR, Human healthcare, General science

Can COVID-19 testing be made more sustainable during prolonged uncertainty?

Posted on Mon, Sep 27, 2021 @ 02:36 PM

In September 2021, Delta persists as the most prevalent variant worldwide1 due to its high infectivity, causing surges ...
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Topics: Molecular diagnostics, qPCR, SARS-CoV-2, Human healthcare, General science

The surprising global impacts of Europe's In Vitro Diagnostic Regulation (IVDR)

Posted on Thu, Sep 16, 2021 @ 12:15 PM

A shortcut to understanding how to prepare for IVDR In today’s global environment, even small regulatory changes in one ...
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Topics: Molecular diagnostics

Oligonucleotide synthesis basics: Introduction to phosphoramidite chemistry

Posted on Tue, Sep 14, 2021 @ 02:00 PM

This is the first blog post in a three-part educational series about best practices for in-house oligonucleotide ...
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Topics: Oligo synthesis and modifications, Human healthcare, General science

4 steps to optimise sample collection for aquaculture genotyping

Posted on Tue, Sep 07, 2021 @ 02:59 PM

Aquaculture breeding programmes adopt genomic technologies, including genotyping, to increase genetic gain for specific ...
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Topics: Agrigenomics, PCR-based genotyping, Nucleic acid extraction

Tips for early-stage MDx companies launching new tests during COVID-19 times

Posted on Thu, Sep 02, 2021 @ 02:00 PM

The COVID-19 pandemic brought tremendous change to the molecular diagnostics (MDx) industry, delivering opportunities ...
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Topics: Molecular diagnostics, SARS-CoV-2, Human healthcare

Wastewater surveillance: a critical tool in pandemic management

Posted on Tue, Aug 31, 2021 @ 09:48 AM

As SARS-CoV-2 variants continue to threaten public health, officials are looking beyond clinical tests to track ...
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Topics: SARS-CoV-2, Human healthcare

Technical bulletin: Emerging SARS-CoV-2 mutations and their effect on the immune response

Posted on Wed, Aug 18, 2021 @ 03:45 PM

Emerging SARS-CoV-2 variants of concern and variants of interest are defined by agencies such as the World Health ...
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Topics: SARS-CoV-2

The importance of sample processing for successful plant genotyping by NGS

Posted on Thu, Aug 12, 2021 @ 06:51 PM

Informed plant breeding decisions help drive the field of agrigenomics towards ever-increasing agricultural ...
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Topics: Agrigenomics, Next generation sequencing (NGS), Nucleic acid extraction

Don't underestimate the complexity of your sample composition

Posted on Wed, Aug 04, 2021 @ 04:34 PM

A common mistake when initiating an agrigenomics project is failing to consider specific sample composition before ...
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Topics: Agrigenomics, Nucleic acid extraction

Selective breeding in aquaculture: advancing breeding programmes through genomics

Posted on Wed, Jun 09, 2021 @ 11:15 AM

The global demand for fish and fish products continues to increase as consumers focus on health-conscious ways to add ...
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Topics: Agrigenomics, Genomics, Applied agrigenomics, General science

Genomic surveillance: 3 techniques to detect and characterise SARS-CoV-2 variants

Posted on Wed, May 19, 2021 @ 11:34 AM

As the global population gains greater access to vaccines for COVID-19, scientists and health officials continue to ...
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Topics: Molecular diagnostics, Genomics, SARS-CoV-2, Human healthcare, General science

How do SARS-CoV-2 variants affect PCR assays for COVID-19 testing?

Posted on Tue, May 04, 2021 @ 11:03 AM

Researchers have identified several variants of SARS-CoV-2 since they sequenced the original viral strain responsible ...
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Topics: Molecular diagnostics, SARS-CoV-2, Human healthcare

Best practices for implementing targeted genotyping by sequencing

Posted on Wed, Dec 02, 2020 @ 10:53 AM

In breeding programmes, selections based on a single or small number of markers to target traits in marker assisted ...
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Topics: Agrigenomics, Genomics, NGS-based genotyping

Building resilience into SARS-CoV-2 testing workflows: considerations for choosing an RNA isolation method

Posted on Wed, Oct 21, 2020 @ 11:00 AM

Clinical and diagnostic labs worldwide are still experiencing supply chain challenges with their SARS-CoV-2 testing ...
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Topics: Molecular diagnostics, Genomics, SARS-CoV-2, Human healthcare, General science

How high-throughput genotyping automation and KASP marker libraries connect research labs with commercial breeders to accelerate crop improvement

Posted on Wed, Oct 07, 2020 @ 11:31 AM

“In July of 2015, I was a member of the radish genome project team. My task was to examine genetic diversity of radish ...
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Topics: Genomics, PCR-based genotyping

Employee spotlight: Meet Darshna "Dusty" Vyas

Posted on Mon, Sep 14, 2020 @ 10:15 AM

Darshna "Dusty" Vyas has been a Senior Scientist at LGC specialising in plant genetics for the past 8 years Her ...
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Topics: Agrigenomics, Genomics, PCR-based genotyping

Pressing COVID-19 testing issues of today and the near future

Posted on Wed, Aug 26, 2020 @ 09:57 AM

Following up with the panelists from our recent COVID-19 webinar, Part 3 of 3 In the previous two blog posts in this ...
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Topics: Molecular diagnostics, Genomics, SARS-CoV-2

Sensitivity and accuracy in COVID-19 testing

Posted on Wed, Aug 19, 2020 @ 09:56 AM

Following up with the panelists from our recent COVID-19 webinar, Part 2 of 3 In the face of a rapidly evolving ...
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Topics: Molecular diagnostics, Genomics, SARS-CoV-2

Scaling up COVID-19 viral testing

Posted on Wed, Aug 12, 2020 @ 09:47 AM

Following up with the panelists from our recent COVID-19 webinar, Part 1 of 3 The COVID-19 pandemic has presented ...
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Topics: Molecular diagnostics, Genomics, SARS-CoV-2

Enabling a rapid response to COVID-19 by Honeywell and LGC, Biosearch Technologies

Posted on Wed, Jul 29, 2020 @ 02:40 PM

As countries worldwide begin to ease lockdown restrictions during the pandemic and prepare to return to “normal” ...
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Topics: Molecular diagnostics, Genomics, qPCR, SARS-CoV-2

Establishment of KASP marker library for genetic diversity analysis in Brassica rapa  crops

Posted on Tue, Jul 14, 2020 @ 10:17 AM

Brassica  rapa crops are important sources of food, feed, and fuel in many parts of the world and provide a unique ...
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Topics: Agrigenomics, Genomics, PCR-based genotyping

Robust supply chains and open testing systems: How our AgBio roots meet the FDA's EUA process to enable solutions to the COVID-19 pandemic

Posted on Tue, May 19, 2020 @ 10:18 AM

It may seem strange that a company known for transforming the global seed breeding industry is uniquely positioned to ...
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Topics: Molecular diagnostics, Genomics, qPCR, SARS-CoV-2

Behind the scenes: How our oligo synthesis team contributes to the reliability of your assays

Posted on Thu, Apr 30, 2020 @ 04:13 PM

We’re not rejecting you, just your oligo PCR is arguably one of the most enabling technologies of modern molecular ...
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Topics: Molecular diagnostics, Oligo synthesis and modifications, Genomics, SARS-CoV-2, Human healthcare, General science

When you don’t need an EUA for SARS-CoV-2 testing

Posted on Fri, Apr 10, 2020 @ 05:00 PM

On March 25, 2020, the US Food and Drug Administration (FDA) held the first of a series of virtual town halls they will ...
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Topics: Molecular diagnostics, SARS-CoV-2

New NGS service lab now open in Middleton, WI for expanded global support

Posted on Wed, Apr 01, 2020 @ 11:27 AM

Back in September 2018, LGC acquired Lucigen Corporation. The ISO accredited site is based in Middleton, Wisconsin and ...
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Topics: Genomics, Next generation sequencing (NGS), NGS-based genotyping

Addressing COVID-19 together: LGC, Biosearch Technologies and Shanghai Liferiver Biotechnology Co., Ltd.

Posted on Tue, Mar 31, 2020 @ 12:13 PM

In the nearly three months since the first confirmed case of COVID-19, the outbreak has become a global crisis, with ...
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Topics: Molecular diagnostics, Oligo synthesis and modifications, Genomics, SARS-CoV-2

What diagnostic test makers and CLIA labs in the US need to know about Emergency Use Authorization (EUA)

Posted on Tue, Mar 24, 2020 @ 01:58 PM

*Since the original publication of this blog, LGC Biosearch Technologies is now the only acceptable commercial supplier ...
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Topics: Molecular diagnostics, Genomics, SARS-CoV-2, Human healthcare, General science

Coronavirus outbreak: Collaboration to meet the challenge

Posted on Mon, Mar 16, 2020 @ 02:30 PM

Coronavirus, or COVID-19, is an infectious virus that is spreading rapidly around the world and the World Health ...
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Topics: Molecular diagnostics, Genomics, SARS-CoV-2

Molecular diagnostics: how can NGS live up to its promises?

Posted on Wed, Jan 29, 2020 @ 11:37 AM

The development of new genomic sequencing techniques and bioinformatics analysis in the last decade has led to massive ...
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Topics: Molecular diagnostics, Next generation sequencing (NGS), Human healthcare

Back to basics - the crucial step of sample collection

Posted on Wed, Jan 15, 2020 @ 11:37 AM

Best practice in sample collection for SeqSNP targeted genotyping by sequencing projects When good goes in, great comes ...
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Topics: Genomics, PCR-based genotyping, NGS-based genotyping

Genomic selection: can it accelerate livestock breeding?

Posted on Wed, May 01, 2019 @ 10:44 AM

Livestock supports the livelihoods and food security of almost 1.3 billion people worldwide, contributing 40% of the ...
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Topics: Agrigenomics, Genomics, Next generation sequencing (NGS), NGS-based genotyping

The women of LGC, Biosearch Technologies

Posted on Fri, Mar 29, 2019 @ 11:24 AM

 We've heard it said for years, "TV will rot your brain". But in the case of our three colleagues below, that ...
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Topics: Genomics

Agrigenomics: how can NGS contribute to global food security?

Posted on Wed, Mar 06, 2019 @ 10:33 AM

“Experience of artificial fertilisation, such as is effected with ornamental plants in order to obtain new variations ...
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Topics: Agrigenomics, PCR-based genotyping, Next generation sequencing (NGS), NGS-based genotyping, Applied agrigenomics

A way to prevent type 1 diabetes?

Posted on Wed, Feb 13, 2019 @ 10:08 AM

Blindness, cardiovascular disease, and stroke are all long-term health problems that can be caused by type 1 diabetes ...
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Topics: Genomics, PCR-based genotyping, Disease detection

How targeted GBS-driven genomic selection can help you get to market faster

Posted on Wed, Jan 16, 2019 @ 01:22 PM

Plant and animal breeding programmes often take generations to improve quality and yield but using a genotyping ...
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Topics: Agrigenomics, Next generation sequencing (NGS), NGS-based genotyping, Applied agrigenomics

Genomic selection: methods in crop and animal breeding

Posted on Wed, Jan 09, 2019 @ 10:48 AM

Genomic selection: 6 factors to consider when choosing between targeted GBS and microarrays
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Topics: Genomics, NGS-based genotyping

Our hungry planet: new tools in agrigenomics are key to food security

Posted on Tue, Dec 11, 2018 @ 10:32 AM

Food security is a major global threat and traditional methods of plant and animal breeding will not be sufficient to ...
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Topics: Agrigenomics, Next generation sequencing (NGS), NGS-based genotyping

Accelerating rice improvement in South Asia

Posted on Thu, Jul 26, 2018 @ 11:26 AM

Diversity is the spice of life and is also key to breeding rice that delivers increased yields. Rice is a crucial ...
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Topics: PCR-based genotyping

Revolutionising cancer treatment one Array at a time

Posted on Tue, Jul 10, 2018 @ 11:05 AM

While the science of pharmacogenomics has been around for years, its popularity is starting to pick up steam as ...
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Topics: Genomics, General science

Pack it up, pack it in, let me begin: A look at the future of DNA data storage

Posted on Thu, Jun 28, 2018 @ 11:13 AM

Imagine a time capsule the size of a shoebox that holds all the information currently on the internet that can be ...
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Topics: Genomics, Nucleic acid extraction

Warning! Pitfalls ahead: How to avoid the most common Stellaris RNA FISH mistakes

Posted on Tue, May 29, 2018 @ 10:32 AM

Ever wake up in the morning just feeling like a rock star, or maybe like Francis Crick, Rosalind Franklin or Maurice ...
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Topics: RNA FISH, Genomics

Shining a light on gene expression and regulation one cell at a time

Posted on Thu, Apr 19, 2018 @ 12:51 PM

To truly understand complex diseases such as cancer, scientists need access to tools that don’t just average data ...
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Topics: RNA FISH, Genomics

The Women of LGC

Posted on Thu, Mar 29, 2018 @ 10:45 AM

Ask any little girl what they want to be when they grow up and you may hear things like, princess, ballerina, pop star, ...
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Topics: Genomics

In case you missed it: Stellaris RNA FISH lunch-and-learn

Posted on Tue, Jan 16, 2018 @ 10:35 AM

Stellaris® RNA FISH (fluorescence in situ hybridization) is an RNA visualization method that allows simultaneous ...
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Topics: RNA FISH, Genomics

Tackling food crisis through cost effective, target enriched sequencing

Posted on Wed, Dec 13, 2017 @ 10:07 AM

With the global population predicted to reach 9 billion people within the next 35 years, we will need to double the ...
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Topics: Agrigenomics, Genomics, NGS-based genotyping, Applied agrigenomics, General science

New SNPs identified in the hunt for new genetic weapons targeting leaf rust in wheat

Posted on Tue, Nov 21, 2017 @ 11:25 AM

Wheat is one of the three most important crops for human and livestock feed. With an ever-increasing global population, ...
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Topics: Agrigenomics, Genomics, PCR-based genotyping

Super-crops helping to feed Africa

Posted on Fri, Nov 03, 2017 @ 11:08 AM

Our world population is growing at a tremendous rate and by 2050, Africa’s population alone is set to hit over 2.5 ...
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Topics: Agrigenomics, Genomics, PCR-based genotyping

How genotyping is aiding in the fight against malaria

Posted on Wed, Sep 20, 2017 @ 10:11 AM

3.2 billion people across 106 countries and territories, live in areas at risk of malaria transmission. The serious and ...
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Topics: Genomics, PCR-based genotyping, Disease detection, Human healthcare, Applied agrigenomics, General science

Lunch & Learn: Stellaris RNA FISH

Posted on Thu, Jul 06, 2017 @ 10:07 AM

Recently LGC Genomics hosted a lunch and learn Stellaris® seminar at the Helen Diller Cancer Institute at UCSF with our ...
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Topics: RNA FISH, Genomics, General science

It’s official! Personal Health becomes first China demonstration laboratory site for LGC’s Nexar System

Posted on Wed, May 03, 2017 @ 09:05 AM

LGC's Genomics Division has signed a memorandum of understanding (MOU) with Chinese health management expert Personal ...
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Topics: Genomics, qPCR, Human healthcare, General science

Digital PCR – improving reproducible molecular methods in the clinic

Posted on Thu, Apr 06, 2017 @ 10:40 AM

A recent study coordinated by LGC and published in the journal Analytical Chemistry, has demonstrated the potential of ...
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Topics: qPCR, Human healthcare, General science

Shining a light on how Zika virus may spread from mothers to human fetuses

Posted on Mon, Mar 06, 2017 @ 10:37 AM

New research has, for the first time, found evidence suggesting the molecular epidemiology of how the Zika virus ...
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Topics: RNA FISH, Disease detection, Human healthcare, General science

Water – Back to Basics for Thermal Cycling

Posted on Tue, Feb 28, 2017 @ 10:13 AM

It’s time to forget what you know about heating your PCR plates for end-point PCR. Water is the way to go. Where ...
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Overcoming drought-intolerance in maize to feed the growing Asian population

Posted on Wed, Feb 15, 2017 @ 09:53 AM

  Demand for maize is increasing due to an increased number of people transitioning to meat-based diets driving demand ...
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Topics: Genomics, PCR-based genotyping, Applied agrigenomics, General science

Automate to Accelerate and Scale-up SNP-based Genotyping Workflows!

Posted on Thu, Feb 02, 2017 @ 09:14 AM

The advent of and ongoing improvements to next-generation sequencing technologies is driving the continuing and ...
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Topics: Genomics, General science

Multiple Misunderstandings: Learning from Genetic Determinism

Posted on Mon, Jan 23, 2017 @ 10:12 AM

Nature versus nurture. It’s a tale as old as time. When Craig Venter made the comment after the human genome sequence ...
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Topics: Genomics, General science

Helping to Feed the World with Genotyping by Sequencing

Posted on Tue, Jan 17, 2017 @ 09:42 PM

Many areas critical to improved agricultural production require robust and scalable genotyping platforms to enable the ...
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Topics: Agrigenomics, Genomics, PCR-based genotyping, NGS-based genotyping, Applied agrigenomics, General science

Faster, stronger, quicker: SSR to KASP will get you there

Posted on Mon, Jan 09, 2017 @ 09:05 AM

Screen more markers faster and bring crops with superior traits to the market quicker.
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Topics: PCR-based genotyping, Applied agrigenomics

Multiplex your qPCR and Walk-away

Posted on Thu, Dec 15, 2016 @ 10:17 AM

It seems everyone wants to do more with less, and automate the process as well.  But this can cause a number of ...
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Topics: Genomics, qPCR, General science

A Stellar-is Year in the Making

Posted on Wed, Dec 07, 2016 @ 10:05 AM

 It wouldn't be fair to close out 2016 without showcasing the stellar year that Stellaris® RNA FISH has had. Take a ...
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Topics: RNA FISH, Genomics, General science

Buddy Up: The Double Helix

Posted on Mon, Nov 28, 2016 @ 09:15 AM

The secret of life. That’s what Francis Crick and James Watson claimed they had discovered back in Cambridge, England ...
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Topics: Genomics, General science

Genes, Proteins & DNA: Our Hereditary Software

Posted on Mon, Nov 21, 2016 @ 09:17 AM

In the early 1900s, scientists found that the function of genes was to make proteins, disproving the earlier idea that ...
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Topics: Genomics, General science

"X" Marks the Spot: A closer look at chromosomes

Posted on Mon, Nov 14, 2016 @ 09:28 AM

The strands of DNA in your cells are organized into pieces called chromosomes. Chromosomes are further organized into ...
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Topics: Genomics, General science

Excel Autocorrect Fails the Genomics Community - Are your Results Excellent or Excel-not?

Posted on Thu, Sep 08, 2016 @ 11:30 AM

Researchers from the Baker IDI Heart and Diabetes Institute in Melbourne, Australia have blamed a default autocorrect ...
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Topics: Genomics, General science

qPCR-based molecular diagnostics at the forefront of Zika surveillance

Posted on Tue, Aug 23, 2016 @ 04:00 PM

As the Zika virus outbreak spreads, a wave of international concern has grown, and scientists have scrambled to ...
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Topics: qPCR, Human healthcare, General science

Know your oligo mod: Thio C6 linker

Posted on Thu, Jul 14, 2016 @ 04:00 PM

Thio C6 Linker (Thiohexyl)  We continue our “Know Your Oligo Mod” series with another versatile custom oligonucleotide ...
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Topics: Oligo synthesis and modifications, Human healthcare, General science

A Complete Ecosystem to Accelerate Breeding Programs [Infographic]

Posted on Tue, Jun 28, 2016 @ 04:00 PM

Modern breeding methods rely on the identification and utilization of molecular markers associated with traits ...
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Topics: Agrigenomics, Applied agrigenomics

Photoblog: Behind the scenes of oligo synthesis

Posted on Wed, May 18, 2016 @ 05:00 PM

OLIGO SYNTHESIS PHOTO GLIMPSE We’ve recently captured our talented manufacturing teams hard at work building oligos. ...
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Topics: Molecular diagnostics, Oligo synthesis and modifications, qPCR, General science

Nova is the new black

Posted on Thu, Apr 14, 2016 @ 04:00 PM

LGC Biosearch Technologies has developed a new qPCR probe format powered by Black Hole Quencher™ technology known as ...
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Topics: qPCR, Human healthcare, General science

Learn about the latest developments in technologies for molecular breeding programs

Posted on Thu, Mar 31, 2016 @ 04:00 PM

At this year’s 24th annual Plant & Animal Genome (PAG) conference, LGC Biosearch Technologies hosted a symposium ...
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Imaging Stellaris Assays Part III: Creating Professional, Publication-ready Images

Posted on Thu, Mar 10, 2016 @ 04:00 PM

Here is the final installment of our “Imaging Stellaris Assays” blog series. In our two previous posts, we’ve gone over ...
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Topics: RNA FISH, General science

Designing Stellaris RNA FISH Probes Part I: Increasing Probe Count

Posted on Thu, Jan 14, 2016 @ 04:00 PM

Stellaris® RNA FISH is a novel technology that allows for the detection of single or clustered RNAs in fixed cells and ...
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Topics: RNA FISH, General science

Know your oligo mod: 3' Spacer C3

Posted on Thu, Oct 15, 2015 @ 04:15 PM

This week, we continue our Know your oligo mod blog series and we will focus on a very basic, yet extremely versatile ...
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Topics: Oligo synthesis and modifications, qPCR, Human healthcare, General science

Imaging Stellaris Assays Part II: How to Acquire Stunning Images

Posted on Thu, Sep 24, 2015 @ 04:30 PM

Here we continue our “Imaging Stellaris Assays” blog series.  We last left off talking about the most important ...
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Topics: RNA FISH, General science

Runaway RNA Stays Put

Posted on Thu, Sep 17, 2015 @ 04:00 PM

The cleavage and polyadenylation event, the final trimming in the molecular mRNA barbershop, normally releases both the ...
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Topics: RNA FISH, General science

Imaging Stellaris Assays Part I: Get to Know Your Microscope

Posted on Thu, Aug 27, 2015 @ 07:00 PM

Stellaris® FISH is an RNA detection technology performed by means of in situ hybridization. This technology and all of ...
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Topics: RNA FISH, General science

The AGCT’s of DNA synthesis

Posted on Tue, Aug 11, 2015 @ 04:00 PM

Chemically synthesized DNA has become an indispensable tool for molecular biologists in the fields of medicine, ...
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Topics: Oligo synthesis and modifications, Human healthcare, General science

Know your oligo mod: BHQ® (Black Hole Quencher®) non-fluorescent quenchers

Posted on Thu, Jul 23, 2015 @ 04:00 PM

In this instalment, we will cover the basics of LGC Biosearch Technologies’ line of proprietary non-fluorescent ...
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Topics: Oligo synthesis and modifications, Human healthcare, General science

And the Consensus (Sequence) is...

Posted on Thu, Jun 11, 2015 @ 04:31 PM

Studying the expression level of RNA transcripts is often complicated by the fact that many DNA sequences are ...
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Topics: RNA FISH, qPCR, Human healthcare, General science

Research Highlight: Bringing Vision Research into Focus

Posted on Thu, May 28, 2015 @ 04:14 PM

Gene expression and molecular biology research in vision and ophthalmology presents unique challenges to researchers ...
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Topics: RNA FISH, General science

FISH-ing for Fusions: A unique approach to fusion gene mRNA & pre-mRNA detection in cancer

Posted on Fri, May 15, 2015 @ 03:00 PM

This past April, Biosearch attended the American Association of Cancer Research (AACR) conference in Philadelphia, PA ...
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Topics: RNA FISH, General science

How Much is Your qPCR Assay Really Costing You?

Posted on Thu, Apr 02, 2015 @ 04:00 PM

In the setup of a qPCR experiment, one of the first decisions to make is which detection method to use. This generally ...
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Topics: qPCR, Human healthcare, General science

The 4Cs of Stellaris® RNA FISH Buffers

Posted on Thu, Feb 26, 2015 @ 04:00 PM

Buffers are often overlooked and taken for granted until the day comes when a peculiar result is observed and its ...
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Topics: RNA FISH, General science

Know your oligo mod: phosphorothioate bonds

Posted on Thu, Feb 12, 2015 @ 04:00 PM

This post in our continuing series, “Know your oligo mod” will cover phosphorothioate bonds, which are available for ...
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Topics: Oligo synthesis and modifications, General science

Optimising multiplex competitive qRT-PCR in diagnostics with BHQplus probes

Posted on Thu, Jan 29, 2015 @ 04:00 PM

In a webinar linked below, Dr. James Willey describes a two colour fluorometric assay for more robust quantitation of ...
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Topics: qPCR, Human healthcare, General science

A Successful Duo for Accurate, Speedy, and Economical SNP Genotyping

Posted on Thu, Jan 08, 2015 @ 01:30 PM

Single Nucleotide Polymorphisms (SNPs) have been widely studied for over 15 years, and have applications in forensics, ...
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Topics: qPCR, PCR-based genotyping, Applied agrigenomics, General science

Know your oligo mod: Methylene Blue

Posted on Tue, Dec 09, 2014 @ 04:02 PM

The chemical synthesis of oligonucleotides allows for the incorporation of a wealth of modifications to an oligo ...
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Topics: Oligo synthesis and modifications, General science

Unraveling the Neural Web: Stellaris® RNA FISH for Neuroscience Research

Posted on Thu, Nov 13, 2014 @ 05:45 PM

Neuroscience gene expression research can come with many hurdles, especially when working with brain tissue or mixed ...
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Topics: RNA FISH, General science

Check out our new website qPCR Design Lab @ qPCRdesign.com

Posted on Thu, Oct 23, 2014 @ 04:00 PM

Biosearch Technologies has launched qPCRdesign.com, a microsite targeted specifically for your quantitative PCR needs. ...
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Topics: qPCR, Human healthcare, General science

Delivering Oligos by Nanomole Units

Posted on Wed, Oct 15, 2014 @ 01:00 PM

Different oligonucleotide manufacturers deliver probes and primers in a variety of different measured units including ...
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Topics: Oligo synthesis and modifications, qPCR, Human healthcare, General science

RT-qPCR Molecular Diagnostics Assist Workers at the Forefront of Ebola Outbreak.

Posted on Thu, Sep 25, 2014 @ 01:30 PM

The largest recorded Ebola Virus Disease outbreak in history continues to devastate the West African region. This ...
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Topics: Molecular diagnostics, qPCR, Human healthcare, General science

One Step too Many? Simplify your qPCR Protocol.

Posted on Thu, Feb 27, 2014 @ 12:02 PM

Don’t waste time performing an extra step. Cut back on pipetting and order a ValuMix™ Assay to have your probes and ...
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Topics: qPCR, Human healthcare, General science

30 Years: The Impact of PCR

Posted on Thu, Sep 05, 2013 @ 11:29 AM

Do you remember when the most popular method of DNA amplification involved multiple hybridizations, followed by single ...
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Topics: qPCR, Human healthcare, General science

RT-qPCR and the Stellaris FISH Method

Posted on Fri, Apr 26, 2013 @ 12:32 PM

A "Referral from the Doctor" Blog Article- Quantitative reverse transcription polymerase chain reaction (RT-qPCR) is a ...
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Topics: RNA FISH, qPCR, Human healthcare, General science

Biosearch Technologies Responds To China Influenza H7N9 Outbreak By Providing H7N9 Detection Panel

Posted on Mon, Apr 15, 2013 @ 08:00 AM

Biosearch Technologies, Inc. (Biosearch) announced today that the company has implemented a rapid response to the ...
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Stellaris® Foundation Genes: GAPDH

Posted on Thu, Apr 11, 2013 @ 11:30 AM

Stellaris probe sets targeting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) mRNA were among the first designed at ...
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Topics: RNA FISH, General science

Biosearch Technologies, UMDNJ Stellaris® Probe Alliance - NextGen Gene Expression™, SNP FISH™, and iceFISH™ in Research and Clinical Applications

Posted on Mon, Mar 18, 2013 @ 10:43 AM

Biosearch Technologies, Inc. (Biosearch), a leading supplier of sophisticated oligonucleotide components to the rapidly ...
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Topics: RNA FISH, General science

Biosearch Technologies Announces Acquisition of European Companies DNA Technology and VitraBio

Posted on Thu, Feb 21, 2013 @ 08:00 AM

Biosearch Technologies, Inc. (Biosearch), a leading supplier of sophisticated, custom-manufactured oligonucleotides and ...
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Biosearch Technologies Launches Catalogued Stellaris™ RNA FISH Assays

Posted on Mon, Jun 18, 2012 @ 10:08 AM

Biosearch Technologies, Inc. (Biosearch), a leading supplier of sophisticated oligonucleotide components to the rapidly ...
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Topics: RNA FISH, General science

Single molecule viral RNA analysis using Stellaris™ FISH technology

Posted on Wed, May 30, 2012 @ 03:00 PM

  Image courtesy of: http://www.cdc.gov/h1n1flu/images.htm A cooperative effort between researchers at Mount Sinai ...
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Topics: RNA FISH, General science

qPCR Probes at work: Innovative CLIA test for NSCLC staging

Posted on Tue, Mar 06, 2012 @ 01:00 PM

Non-squamous, Non-small cell lung cancer (NSCLC), the most common cause of death in the US and globally, has recently ...
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Topics: Molecular diagnostics, qPCR, Human healthcare, General science

Factors affecting fluorophore performance in qPCR

Posted on Wed, Jan 11, 2012 @ 11:00 AM

Fluorophores are molecules that can absorb light energy in a process called excitation and re-emit light energy at a ...
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Topics: qPCR, Human healthcare, General science

The 'Monte Carlo' Effect in qPCR

Posted on Wed, Nov 09, 2011 @ 01:00 PM

A "Referral from the Doctor" Blog Article- The mathematical model of PCR is based on the assumption that each DNA ...
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Fluorescence Quenching Mechanisms for Dual-Labeled Probes

Posted on Wed, Jun 29, 2011 @ 09:44 AM

A "Referral from the Doctor" Blog Article- Fluorescent probes are used in biochemical assays to monitor specific events ...
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Topics: qPCR, Human healthcare, General science

Multiplexing with Xanthenes

Posted on Wed, Jun 08, 2011 @ 11:13 AM

A "Referral from the Doctor" Blog Article- Quantitative real-time PCR (qPCR) was developed as a means to detect the ...
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Topics: qPCR, Human healthcare, General science

qPCR troubleshooting: interpreting amplification curves and diagnosing problems

Posted on Thu, May 05, 2011 @ 12:15 PM

If you run quantitative real-time PCR (qPCR) assays, the chances are that you’ve seen some strange looking ...
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Topics: qPCR, Human healthcare, General science

Between ROX and a Hard Place

Posted on Wed, Nov 10, 2010 @ 11:12 AM

A "Referral from the Doctor" Blog Article- ROX in qPCR Quantitative real-time RT-PCR was developed as a means of ...
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Topics: qPCR, Human healthcare, General science

Visit Biosearch at IVD Technology's Virtual Conference and Tradeshow

Posted on Thu, Sep 23, 2010 @ 04:32 PM

Biosearch Technologies is proud to sponsor the first IVD Technology Virtual Conference and Tradeshow. This free online ...
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Topics: Molecular diagnostics, Human healthcare

PilotDx Oligos: En Route to IVD

Posted on Thu, Jul 22, 2010 @ 10:07 AM

It can be difficult to transition a product from research to commercialization. It’s simply not feasible to conduct ...
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Topics: Molecular diagnostics, Human healthcare

Pipetting for qPCR

Posted on Wed, Jun 09, 2010 @ 10:41 AM

A "Referral from the Doctor" Blog Article- Research trends in laboratories today increasingly steer towards gene ...
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Topics: qPCR, Human healthcare, General science

Killer probes for qPCR: what is a Scorpions Primer?

Posted on Wed, Mar 24, 2010 @ 10:57 AM

Scorpions™ Primers are dual-labeled FRET probes that combine a Molecular Beacon-like probe structure and a PCR primer ...
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Topics: qPCR, Human healthcare, General science

A light in the storm: what is a Molecular Beacon?

Posted on Wed, Mar 10, 2010 @ 01:05 PM

Molecular Beacons are a special type of dual-labeled oligonucleotide probe. Beacons are hairpin loop structures with a ...
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Topics: qPCR, Human healthcare, General science

Dual-labeled BHQ probes - Performance to “dye” for

Posted on Wed, Feb 24, 2010 @ 12:20 PM

A "Referral from the Doctor" Blog Article A BHQ® probe is a dual-labeled oligonucleotide covalently labeled with a ...
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Topics: qPCR, Human healthcare, General science

This Year's MVP (Most Valuable Practice): Touchdown PCR

Posted on Thu, Feb 04, 2010 @ 12:39 PM

A "Referral from the Doctor" Blog Article-   The aim of the Polymerase Chain Reaction (PCR) method is to amplify or ...
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Topics: qPCR, Human healthcare, General science

The Grand Ballet: Wine and Biotechnology

Posted on Wed, Jan 27, 2010 @ 01:15 PM

At the third qPCR Symposium, held November 9th -12th in Millbrae, CA, ETS laboratories (ETS) scientist Rich DeScenzo ...
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Topics: qPCR, Human healthcare, General science

Alternative to DNAse I heat inactivation

Posted on Wed, Jan 13, 2010 @ 12:04 PM

A "Referral from the Doctor" Blog Article- Genomic DNA contamination has been a hot topic for qPCR researchers since ...
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Topics: qPCR, Human healthcare, General science

A Quick Jump Start to Multiplexing qPCR

Posted on Wed, Jan 06, 2010 @ 12:01 PM

By now, you've no doubt read about the reductions in error, cost and time that can be achieved by multiplexing ...
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Topics: qPCR, Human healthcare, General science

Slope Efficiency Equals Manageable and Corrected PCR

Posted on Wed, Dec 09, 2009 @ 02:01 PM

A "Referral from the Doctor" Blog Article-   ε = m.c.2 (shall I explain? slope efficiency equals manageable and ...
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Topics: qPCR, Human healthcare, General science

Bringing Back a Champion: Competitive Quantitative Real-time RT-PCR

Posted on Wed, Nov 18, 2009 @ 10:08 AM

A "Referral from the Doctor" Blog Article- Competitive qRT-PCR has become a lost art. Early titans of probe-based PCR ...
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Topics: qPCR, Human healthcare, General science

The New Favorite Reference Gene: 36B4, a.k.a. RPLP0

Posted on Wed, Oct 14, 2009 @ 10:06 AM

A "Referral from the Doctor" Blog Article- Ribosomes are comprised of two subunits, one small (40S) and one large ...
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Topics: Oligo synthesis and modifications, qPCR, Human healthcare, General science

What Genes are Hot, What Genes are Not

Posted on Wed, Oct 07, 2009 @ 04:41 PM

 A "Referral from the Doctor" Blog Article-  Top 10 Reference Genes for probe-based Real-time PCR in 2009: • Acidic ...
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Topics: qPCR, Human healthcare, General science

Labeling oligonucleotides with internal BHQ dyes

Posted on Tue, Sep 29, 2009 @ 10:16 AM

  When to use an internal Black Hole Quencher (BHQ) label in a fluorescence-quenched probe for real-time qPCR? When the ...
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Topics: Oligo synthesis and modifications, qPCR, Human healthcare, General science

Salt-Free Primer Pair Option Now Available

Posted on Tue, Sep 22, 2009 @ 10:08 AM

Biosearch Technologies will now be offering the option of salt-free primer pairs for purchase with any probe order. A ...
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Topics: Oligo synthesis and modifications, qPCR, Human healthcare, General science

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LGC, Biosearch Technologies is the complete Genomics portfolio from LGC. Providing genomic analysis tools, instrumentation and services to the genomic scientific discovery sector worldwide, with focus on across ag bio, pharma and molecular diagnostics. Visit our home page to view our products and services.

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