How to select an effective nucleic acid isolation method for human diagnostics

How to select an effective nucleic acid isolation method for human diagnostics

Molecular testing protocols for pathogen detection and diagnosing human diseases require reliable and high-quality isolation of genetic material from diverse sample types. There are many extraction and purification technologies available. Before deciding which isolation method best suits your application, read this blog that walks you through key considerations...

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A way to simplify design and interpretation of your qPCR assays

Posted on Fri, May 05, 2023 @ 09:34 AM

How does a BHQ dye contribute to producing superior data from your assays?
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Topics: Molecular diagnostics, Oligo synthesis and modifications, qPCR, Human healthcare, General science

Which controlled pore glass is right for your therapeutic application?

Posted on Fri, Mar 31, 2023 @ 10:48 AM

Oligonucleotide therapeutics have unlocked new treatment possibilities for rare and fatal diseases often associated ...
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Topics: Oligo synthesis and modifications, Nucleic acid therapeutics, Human healthcare

5-Nitroindole – a universal base oligo modification

Posted on Thu, Feb 16, 2023 @ 09:27 AM

In the next edition of the “Know your oligo mod” series, we look at a universal base analogue for oligonucleotide ...
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Topics: Oligo synthesis and modifications, Human healthcare, General science

What’s next for aptamers in diagnostics?

Posted on Thu, Nov 10, 2022 @ 08:17 AM

Originally developed in the early 1990s, aptamers have long been heralded as an antibody alternative for detection ...
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Topics: Molecular diagnostics, Oligo synthesis and modifications, Human healthcare

Where are all the therapeutic aptamers?

Posted on Tue, Aug 09, 2022 @ 02:10 PM

New approaches that use aptamers as targeting agents may open the door to wider clinical use in the future
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Topics: Oligo synthesis and modifications, Nucleic acid therapeutics, General science

Choosing the best qPCR probe chemistry for your assay

Posted on Thu, Jul 28, 2022 @ 10:15 AM

Let the application be your guide when deciding between LNA, MGB and BHQplus  The many different chemistries available ...
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Topics: Molecular diagnostics, Oligo synthesis and modifications, qPCR, Human healthcare, General science

Overcoming manufacturing challenges associated with nucleic acid therapeutics

Posted on Thu, Mar 24, 2022 @ 06:15 PM

This is the second blog in a two-part series exploring how oligonucleotide modifications can support the advancement of ...
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Topics: Oligo synthesis and modifications, Nucleic acid therapeutics, Human healthcare

Nucleic acid therapeutics for next-generation disease management

Posted on Fri, Feb 25, 2022 @ 02:47 PM

This is the first blog post in a two-part series exploring how oligonucleotide modifications can support the ...
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Topics: Oligo synthesis and modifications, Nucleic acid therapeutics, Human healthcare

Leveraging quenching efficiency of Black Hole Quencher dyes for PCR and beyond

Posted on Tue, Jan 25, 2022 @ 02:30 PM

More innovative applications for Black Hole Quencher (BHQ) dyes In imaging and detection assay development, innovative ...
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Topics: Oligo synthesis and modifications

Oligonucleotide synthesis basics: Key takeaways for post-synthesis processing

Posted on Thu, Dec 16, 2021 @ 04:39 PM

This is the final blog post in a three-part educational series about best practices for in-house oligonucleotide ...
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Topics: Oligo synthesis and modifications, Human healthcare, General science

Innovative applications for Black Hole Quencher dyes

Posted on Tue, Nov 16, 2021 @ 04:14 PM

This is the first blog post in a two-part series highlighting how Black Hole Quencher™ dyes can be incorporated into ...
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Topics: Molecular diagnostics, Oligo synthesis and modifications

Oligonucleotide synthesis basics: 4 key takeaways for in-house oligo production

Posted on Tue, Nov 02, 2021 @ 11:41 AM

This is the second blog post in a three-part educational series about best practices for in-house oligonucleotide ...
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Topics: Oligo synthesis and modifications, General science

Oligonucleotide synthesis basics: Introduction to phosphoramidite chemistry

Posted on Tue, Sep 14, 2021 @ 02:00 PM

This is the first blog post in a three-part educational series about best practices for in-house oligonucleotide ...
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Topics: Oligo synthesis and modifications, Human healthcare, General science

Behind the scenes: How our oligo synthesis team contributes to the reliability of your assays

Posted on Thu, Apr 30, 2020 @ 04:13 PM

We’re not rejecting you, just your oligo PCR is arguably one of the most enabling technologies of modern molecular ...
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Topics: Molecular diagnostics, Oligo synthesis and modifications, Genomics, SARS-CoV-2, Human healthcare, General science

Addressing COVID-19 together: LGC, Biosearch Technologies and Shanghai Liferiver Biotechnology Co., Ltd.

Posted on Tue, Mar 31, 2020 @ 12:13 PM

In the nearly three months since the first confirmed case of COVID-19, the outbreak has become a global crisis, with ...
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Topics: Molecular diagnostics, Oligo synthesis and modifications, Genomics, SARS-CoV-2

Know your oligo mod: Thio C6 linker

Posted on Thu, Jul 14, 2016 @ 04:00 PM

Thio C6 Linker (Thiohexyl)  We continue our “Know Your Oligo Mod” series with another versatile custom oligonucleotide ...
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Topics: Oligo synthesis and modifications, Human healthcare, General science

Photoblog: Behind the scenes of oligo synthesis

Posted on Wed, May 18, 2016 @ 05:00 PM

OLIGO SYNTHESIS PHOTO GLIMPSE We’ve recently captured our talented manufacturing teams hard at work building oligos. ...
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Topics: Molecular diagnostics, Oligo synthesis and modifications, qPCR, General science

Know your oligo mod: 3' Spacer C3

Posted on Thu, Oct 15, 2015 @ 04:15 PM

This week, we continue our Know your oligo mod blog series and we will focus on a very basic, yet extremely versatile ...
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Topics: Oligo synthesis and modifications, qPCR, Human healthcare, General science

The AGCT’s of DNA synthesis

Posted on Tue, Aug 11, 2015 @ 04:00 PM

Chemically synthesized DNA has become an indispensable tool for molecular biologists in the fields of medicine, ...
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Topics: Oligo synthesis and modifications, Human healthcare, General science

Know your oligo mod: BHQ® (Black Hole Quencher®) non-fluorescent quenchers

Posted on Thu, Jul 23, 2015 @ 04:00 PM

In this instalment, we will cover the basics of LGC Biosearch Technologies’ line of proprietary non-fluorescent ...
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Topics: Oligo synthesis and modifications, Human healthcare, General science

Know your oligo mod: phosphorothioate bonds

Posted on Thu, Feb 12, 2015 @ 04:00 PM

This post in our continuing series, “Know your oligo mod” will cover phosphorothioate bonds, which are available for ...
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Topics: Oligo synthesis and modifications, General science

Know your oligo mod: Methylene Blue

Posted on Tue, Dec 09, 2014 @ 04:02 PM

The chemical synthesis of oligonucleotides allows for the incorporation of a wealth of modifications to an oligo ...
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Topics: Oligo synthesis and modifications, General science

Delivering Oligos by Nanomole Units

Posted on Wed, Oct 15, 2014 @ 01:00 PM

Different oligonucleotide manufacturers deliver probes and primers in a variety of different measured units including ...
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Topics: Oligo synthesis and modifications, qPCR, Human healthcare, General science

The New Favorite Reference Gene: 36B4, a.k.a. RPLP0

Posted on Wed, Oct 14, 2009 @ 10:06 AM

A "Referral from the Doctor" Blog Article- Ribosomes are comprised of two subunits, one small (40S) and one large ...
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Topics: Oligo synthesis and modifications, qPCR, Human healthcare, General science

Labeling oligonucleotides with internal BHQ dyes

Posted on Tue, Sep 29, 2009 @ 10:16 AM

  When to use an internal Black Hole Quencher (BHQ) label in a fluorescence-quenched probe for real-time qPCR? When the ...
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Topics: Oligo synthesis and modifications, qPCR, Human healthcare, General science

Salt-Free Primer Pair Option Now Available

Posted on Tue, Sep 22, 2009 @ 10:08 AM

Biosearch Technologies will now be offering the option of salt-free primer pairs for purchase with any probe order. A ...
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Topics: Oligo synthesis and modifications, qPCR, Human healthcare, General science

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About LGC, Biosearch Technologies

LGC, Biosearch Technologies is the complete Genomics portfolio from LGC. Providing genomic analysis tools, instrumentation and services to the genomic scientific discovery sector worldwide, with focus on across ag bio, pharma and molecular diagnostics. Visit our home page to view our products and services.

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