Make your diagnostic workflows more adaptable

Updated : Fri, December 16, 2022 @ 3:39 PM

Since early 2020, diagnostic laboratories have had to manage patient sample quantities being in a state of flux. Demand for COVID-19 testing has once again decreased, leaving laboratory managers with the opportunity to re-evaluate their molecular diagnostic workflows. Many labs greatly increased their capacity for qPCR and RT-qPCR in response to the pandemic, but may face barriers to repurposing this infrastructure due to existing kits being incompatible with additional sample types or downstream applications. 

Using instruments and kits that allow you to adapt with changing priorities, such as a sudden increase or decrease in SARS-CoV-2 testing, or a different outbreak, offers great advantages. Laboratory staff can benefit from reduced bottlenecks and simplified training, while patients and clinicians can receive results with faster turnaround times. 

Choosing a nucleic acid isolation technology that can be applied across a range of sample matrices and pathogens allows you to realise these benefits, while also enabling a streamlined ordering and supply management process.

The LGC Biosearch Technologies sbeadex™ Pathogen Nucleic Acid Purification Kit is applicable for a wide range of matrices, making it suitable to be used for STI and gastrointestinal pathogen detection panels, alongside seamless scaling up and down of COVID-19 testing. It cuts out the need for multiple purification  kits, which is ideal for labs exploring their molecular testing portfolio. 


Have confidence in the quality of your purification  

The sbeadex Pathogen Nucleic Acid Purification Kit provides the highest analytical sensitivity to detect a wide range of viral, bacterial and yeast pathogens as it is based on a novel, unique two-step binding chemistry. Its wash buffers contain no ethanol – resulting in a final eluate with highly purified nucleic acids and no inhibitors that would normally impact PCR and NGS applications. 

Nucleic acid isolation can critically impact your data if the yield and purity are not suitable for your downstream application. By starting with a high-quality purification, you can avoid failed diagnostics and having to resample and repeat your tests.

Flexible nucleic acid purification for all your pathogens 

Previous verification studies demonstrated the applicability of the kit for purification of nucleic acid from a range of bacteria and viruses that cause common respiratory diseases and atypical pneumonia.

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 Further verification studies have since verified the kit for high-quality DNA and RNA purification from a broad range of human sample matrices and corresponding viral, bacterial and yeast pathogens. The list of pathogens verified for use with the kit include: SARS-CoV-2, influenza, RSV, Cytomegalovirus, Mycoplasma, Chlamydia, Salmonella, Mycobacterium, Clostridioides, Candida and more. 

The list of compatible matrices tested includes: 

  • Swabs (universal transport medium/viral transport medium) 
  • Sputum 
  • Saliva 
  • Blood 
  • Plasma 
  • Serum 
  • Urine 
  • Stool 
  • Cerebrospinal Fluid 

See our website for up-to-date information on the list of pathogens and matrices tested. 

How it works

LGC Biosearch Technologies’ sbeadex purification kits use magnetic separation for the purification of nucleic acids. They are versatile and can be used with a wide variety of sample types and automation instruments. Superparamagnetic particles coated with sbeadex surface chemistry use a novel two-step binding mechanism which, when combined with the washing steps, removes impurities from the preparation. The absence of organic solvents in the final wash step means no drying step is needed, which reduces time to results. After washing, the nucleic acid is eluted from the magnetic particles and is ready for use in downstream PCR, RT-PCR and NGS applications. 

Optimise your throughput 

The sbeadex Pathogen Nucleic Acid Purification Kit can be used for all scales of nucleic acid preparation, however it is particularly well suited for incorporation into automated high-throughput workflows. Our sbeadex kits are compatible with most popular robotic platforms, including the Kingfisher™ and our high-throughput oKtopure™ instrument, which can purify up to 4,000 samples per day with full walk-away automation after the lysis step. 


In this poster presented at the Association for Molecular Pathology Conference 2022 in Phoenix, AZ we demonstrate how the sbeadex Pathogen Nucleic Acid Purification Kit is suitable for high-throughput pathogen detection workflows and multiple downstream analyses. 

We’ve verified that the sbeadex kit can be used to purify nucleic acids from yeast, various bacterial and viral pathogens, including SARS-CoV-2, and from multiple sample matrices in a single protocol with an adjustable lysis step.

Depending upon sample type and pathogen of interest we show that the lysis step could be omitted or performed for 3 minutes or for ≥10 minutes. We found that pathogenic DNA in whole blood could be reliably detected for all analysed time points but pathogenic RNA was most efficiently detected when lysis time was limited to 3 minutes.
View poster here


With both short (25 minute) and standard (45 minute) protocols available, you can be sure that sbeadex will deliver fast turnaround times, easy automation and high-quality nucleic acids for your PCR and NGS applications. 

Supporting your services

As priorities shift from COVID-19 testing, our experts will partner with your lab to help you re-evaluate your service offerings. LGC Biosearch Technologies offers a comprehensive portfolio of off-the-shelf kits for use in PCR-based pathogen detection and high-quality individual assay components to support diagnostic assays. In addition, we also provide economic bulk amounts as well as customised solutions tailored to your specific needs. 


Related content

How to select an effective nucleic acid isolation method for human diagnostics?

Optimising automated high-throughput pathogen detection workflows

Choosing the best qPCR probe chemistry for your assay


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About LGC, Biosearch Technologies

LGC, Biosearch Technologies is the complete Genomics portfolio from LGC. Providing genomic analysis tools, instrumentation and services to the genomic scientific discovery sector worldwide, with focus on across ag bio, pharma and molecular diagnostics. Visit our home page to view our products and services.

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