By Austin Sheppe PhD, LGC Biosearch Technologies withcontributionsby Dusty Vyas, Senior Scientist LGC Biosearch T...
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The BiosearchTech Blog
Stay up to date on all matters assay development and optimisation whether you work within human healthcare or agrigenomics. Written and curated by scientists for scientists, receive new articles straight to your inbox twice monthly.
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The BiosearchTech Blog
Agrigenomics Next generation sequencing (NGS) Targeted GBS
A guide to selecting the optimum trait mapping genotyping tool within your budget
Posted on Mon, Oct 07, 2024 @ 09:15 AM
Molecular diagnostics NGS-based genotyping Nucleic acid extraction
From customer problems to custom solutions: our scientists reveal how it works
Posted on Wed, Sep 25, 2024 @ 10:00 AM
Our scientists and product specialists work in close collaboration with a diverse range of customers to find solutions...
Genomics Nucleic acid therapeutics
What’s next for nucleic acid therapeutics?
Posted on Tue, Sep 24, 2024 @ 12:48 PM
Dozens of oligonucleotide-based therapeutics are already on the market, helping to treat a range of life-threatening...
Genomics Nucleic acid therapeutics
The landscape of nucleic acid therapeutics
Posted on Fri, Aug 30, 2024 @ 09:00 AM
With the rapid deployment of the mRNA COVID-19 vaccines and the recent approval of the first CRISPR gene therapy, the...
Genotyping dung advances conservation of endangered forest elephants
Posted on Fri, Aug 23, 2024 @ 02:13 AM
African forest elephants are considered a keystone species due to their positive impact on the forest ecosystem. As the...
qPCR PCR-based genotyping oligos probes and primers
We answer your most common questions about MGB Probes
Posted on Mon, Aug 12, 2024 @ 11:22 AM
Need high specificity and shorter probes for your hybridisation assays? If you are considering Minor Groove Binder...
How the International Crops Research Institute for the Semi-Arid Tropics used KASP to advance genotyping solutions for sorghum breeding
Posted on Tue, Jul 30, 2024 @ 10:00 AM
Sorghum[Sorghum bicolor (L.) Moench] is a diploid cereal crop used for food, drink (beer), livestock feed, fuel and as...
Molecular diagnostics Disease detection
Overcoming the challenge of primer-dimers in multiplexed PCR assays
Posted on Tue, Jun 18, 2024 @ 09:30 AM
Although PCR is often viewed as a gold standard for molecular diagnostic tests, the problem of non-specific primer...
Oligo synthesis and modifications qPCR NGS-based genotyping KASP CPG
What are our team’s favourite products?
Posted on Fri, May 31, 2024 @ 04:03 AM
Our scientists can’t agree!
Our portfolio covers a wide range of products supporting research, development and...
Oligo synthesis and modifications
Know your oligo mod: 2ʹ-MOE
Posted on Mon, May 13, 2024 @ 03:49 AM
The "Know your oligo mod" series continues with a deep dive into the 2'-O-methoxyethyl (2'-MOE) modification, a major...
Molecular diagnostics Disease detection
How thermostable DNA ligase can help to detect rare point mutations
Posted on Tue, Apr 30, 2024 @ 07:25 AM
Detecting single nucleotide variations (SNVs) offers powerful actionable insights in diagnosing diseases, monitoring...
A new and greener approach for manufacturing CPGs
Posted on Mon, Apr 15, 2024 @ 12:28 PM
With more companies than ever innovating in precision medicine, drug discovery, therapeuticdevelopment and genetic...
Oligo synthesis and modifications
Know your oligo mod: ATTO dyes
Posted on Mon, Mar 11, 2024 @ 04:50 PM
In this latest instalment of our 'Know Your Oligo Mod' blog series, we explore the benefits of high-performance ATTO...
Oligo synthesis and modifications
Optimise oligo synthesis and design for effective CRISPR therapeutics
Posted on Wed, Feb 21, 2024 @ 09:41 AM
In November 2023, the UK became the first country in the world to approve a gene therapy based on CRISPR-Cas9...
Reduce SNP deserts when genotyping to inform breeding and trait stacking
Posted on Wed, Jan 31, 2024 @ 07:58 AM
Creating a crop that is more effective at meeting the needs of farmers and end consumers is the aim of every plant...
Molecular diagnostics Disease detection
How to choose the right competent cells for phage display
Posted on Wed, Jan 24, 2024 @ 11:42 AM
Since Humira (adalimumab) became the first approved monoclonal antibody therapy developed using phage display in 2002,...
Agrigenomics Next generation sequencing (NGS) NGS-based genotyping
How potato breeders use Flex-Seq to battle against late blight disease
Posted on Mon, Dec 18, 2023 @ 10:19 AM
Potato (Solanum tuberosum) is the world’s third most important food crop after wheat and cereal and is a staple food...
Molecular diagnostics Genomics
Molecular marvels: choosing the most suitable reverse transcriptase
Posted on Fri, Dec 01, 2023 @ 11:02 AM
Image credit: HIV Reverse Transcriptase. RCSB Protein Data Bank. The Wellcome Collection.
Controlling for contamination in qPCR testing
Posted on Fri, Dec 01, 2023 @ 10:26 AM
Disease detection Nucleic acid therapeutics
Why circular RNA could be the next revolution in RNA therapeutics
Posted on Wed, Nov 22, 2023 @ 10:47 AM
While RNA-based therapeutics are taking the biotechnology world by storm following the rapid development of the...
Oligo synthesis and modifications Nucleic acid therapeutics
Synthesizing your own oligonucleotides: FAQs
Posted on Tue, Nov 07, 2023 @ 08:30 AM
How to design mRNA therapeutics for scalable success
Posted on Thu, Oct 26, 2023 @ 11:09 AM
Agrigenomics Next generation sequencing (NGS) NGS-based genotyping
Increasing livestock breeding profitability with genomic selection
Posted on Tue, Oct 17, 2023 @ 01:23 PM
How does genomic selection increase profitability?
Molecular diagnostics Disease detection
The rise of LAMP for rapid point-of-need testing
Posted on Thu, Sep 28, 2023 @ 02:30 PM
As the world scrambled to rapidly expand PCR testing capacity in 2020, it became increasingly clear that there was a...
Oligo synthesis and modifications
“Click” your way towards discovery and innovation
Posted on Fri, Sep 08, 2023 @ 04:08 AM
Labelling, linking or modifying biomolecules used to be a laborious process, requiring customised complex synthetic...
Minimising antibiotic dependency for treating UTIs and STIs
Posted on Tue, Aug 15, 2023 @ 04:40 AM
Agrigenomics NGS-based genotyping
US Dept of Agriculture dives into blueberry and cranberry genotyping
Posted on Fri, Jul 28, 2023 @ 10:20 AM
Every year over 1.5 million tonnes of blueberries and over half a million tonnes of cranberries are produced. This is...
Oligo synthesis and modifications Nucleic acid therapeutics
What’s the latest in ASO and siRNA technologies?
Posted on Fri, Jul 07, 2023 @ 10:40 AM
Molecular diagnostics Nucleic acid extraction
Ditch the spin columns without compromising on nucleic acid quality
Posted on Thu, Jun 29, 2023 @ 11:41 AM
Why genome-editing CRISPR/Cas offers hope for accelerated sustainable crop improvement in oil palm
Posted on Thu, Jun 01, 2023 @ 11:09 AM
Updated : Thu, June 1, 2023 @ 4:09 PM
Oil palm, Elaeis guineensis Jacq., is the most productive oil crop in the world1...
Mastering assay scale-up: 4 tips to help avoid the most common mistakes
Posted on Thu, May 25, 2023 @ 10:19 AM
Updated : Fri, May 26, 2023 @ 10:18 AM
Designing a new assay and scaling it for commercial use takes thoughtful...
A knack for getting to the liver: GalNAc enables liver-targeted oligonucleotide therapeutics
Posted on Wed, May 24, 2023 @ 10:06 AM
Updated : Tue, May 9, 2023 @ 11:03 AM
When it comes to oligonucleotide therapeutics, the challenge has always been how...
Molecular diagnostics Oligo synthesis and modifications qPCR
A way to simplify design and interpretation of your qPCR assays
Posted on Fri, May 05, 2023 @ 09:34 AM
Updated : Fri, May 5, 2023 @ 2:34 PM
How does a BHQ dye contribute to producing superior data from your assays?
Oligo synthesis and modifications Nucleic acid therapeutics
Which controlled pore glass is right for your therapeutic application?
Posted on Fri, Mar 31, 2023 @ 10:48 AM
Updated : Mon, June 26, 2023 @ 10:24 AM
Oligonucleotide therapeutics have unlocked new treatment possibilities for rare...
Agrigenomics PCR-based genotyping
Enhancing strawberry breeding with predictive models, marker-assisted selection and genotyping automation
Posted on Wed, Mar 08, 2023 @ 06:09 AM
Updated : Tue, May 9, 2023 @ 10:48 AM
Around 159,200 tonnes of strawberries are produced annually in Japan across 5,020...
Oligo synthesis and modifications
5-Nitroindole – a universal base oligo modification
Posted on Thu, Feb 16, 2023 @ 09:27 AM
Updated : Tue, May 9, 2023 @ 10:51 AM
In the next edition of the “Know your oligo mod” series, we look at a universal...
Celebrating the women of LGC 2023
Posted on Fri, Feb 10, 2023 @ 04:13 AM
Updated : Tue, May 9, 2023 @ 10:53 AM
This International Day of Women and Girls in Science (11 February) LGC Biosearch...
Agrigenomics PCR-based genotyping
How MGB probes could solve your complex plant genome genotyping issues
Posted on Thu, Jan 26, 2023 @ 01:34 PM
Updated : Wed, March 22, 2023 @ 1:48 PM
Genotyping plants can be a complex and frustrating process
Molecular diagnostics SARS-CoV-2 Disease detection
AMP conference 2022: Developing a 5-minute point-of-care PCR test
Posted on Wed, Jan 11, 2023 @ 08:15 AM
Updated : Tue, May 9, 2023 @ 10:57 AM
We were delighted to attend the Association for Molecular Pathology (AMP) 2022...
Molecular diagnostics Oligo synthesis and modifications
What’s next for aptamers in diagnostics?
Posted on Thu, Nov 10, 2022 @ 07:25 AM
Updated : Tue, May 9, 2023 @ 11:01 AM
Originally developed in the early 1990s, aptamers have long been heralded as an...
Molecular diagnostics Nucleic acid extraction
How to select an effective nucleic acid isolation method for human diagnostics?
Posted on Tue, Oct 18, 2022 @ 10:19 AM
Updated : Tue, May 9, 2023 @ 11:05 AM
Molecular testing protocols for pathogen detection and diagnosing human diseases...
Agrigenomics PCR-based genotyping
Explore the vast applications of KASP genotyping for plant breeding programmes
Posted on Tue, Sep 20, 2022 @ 06:45 AM
Updated : Wed, March 22, 2023 @ 1:22 PM
Modern agriculture faces unprecedented challenges: increasing global...
Taq Polymerase: what is it and its applications
Posted on Fri, Aug 26, 2022 @ 07:58 AM
Updated : Wed, December 14, 2022 @ 1:54 PM
When the polymerase chain reaction (PCR) was first described, the Klenow...
Oligo synthesis and modifications Nucleic acid therapeutics
Where are all the therapeutic aptamers?
Posted on Tue, Aug 09, 2022 @ 02:10 PM
Updated : Tue, August 9, 2022 @ 7:10 PM
New approaches that use aptamers as targeting agents may open the door to wider...
Molecular diagnostics Oligo synthesis and modifications qPCR
Choosing the best qPCR probe chemistry for your assay
Posted on Thu, Jul 28, 2022 @ 10:15 AM
Updated : Tue, May 9, 2023 @ 10:40 AM
Let the application be your guide when deciding between LNA, MGB and BHQplus
The...
Molecular diagnostics Disease detection
Pivoting to monkeypox diagnostics
Posted on Thu, Jul 07, 2022 @ 05:38 PM
Updated : Thu, July 7, 2022
Since 13 May 2022, reports of monkeypox cases began to appear globally in regions not...
Agrigenomics PCR-based genotyping NGS-based genotyping
Genetic solutions to infectious diseases in aquaculture
Posted on Thu, Jun 30, 2022 @ 04:12 PM
Updated : Mon, April 17, 2023 @ 8:33 AM
This is the second blog in a two-part series exploring solutions for infectious...
SARS-CoV-2 Nucleic acid extraction Disease detection
Make your diagnostic workflows more adaptable
Posted on Mon, Jun 06, 2022 @ 02:47 PM
Updated : Fri, December 16, 2022 @ 3:39 PM
Since early 2020, diagnostic laboratories have had to manage patient sample...
Increasing resistance to aquaculture disease
Posted on Tue, Apr 19, 2022 @ 11:00 AM
Updated : Mon, April 17, 2023 @ 1:33 PM
This is the first blog in a two-part series exploring solutions for infectious...
Pandemic reflections: Adapting to testing priorities
Posted on Tue, Apr 05, 2022 @ 04:55 PM
Updated : Tue, March 21, 2023 @ 3:23 PM
What’s changed for clinical labs as we enter the third year of COVID-19 testing?
Optimising automated high-throughput pathogen detection workflows
Posted on Wed, Mar 30, 2022 @ 11:00 AM
Updated : Wed, March 30, 2022 @ 4:00 PM
While both centralised and decentralised molecular diagnostics (MDx) testing...
Oligo synthesis and modifications Nucleic acid therapeutics
Overcoming manufacturing challenges associated with nucleic acid therapeutics
Posted on Thu, Mar 24, 2022 @ 06:15 PM
Updated : Tue, March 21, 2023 @ 3:46 PM
This is the second blog in a two-part series exploring how oligonucleotide...
Agrigenomics qPCR PCR-based genotyping
Improving the sustainability of oil palm breeding programmes using marker-assisted selection
Posted on Tue, Mar 08, 2022 @ 03:00 PM
Updated : Wed, March 9, 2022 @ 1:05 AM
African oil palm (Elaeis guineensis Jacq.) is a highly productive perennial crop...
Considerations for RT-qPCR in molecular point of care testing devices
Posted on Tue, Mar 01, 2022 @ 03:11 PM
Updated : Fri, April 15, 2022 @ 8:58 PM
The COVID-19 pandemic has accelerated the uptake of point of care testing...
Oligo synthesis and modifications Nucleic acid therapeutics
Nucleic acid therapeutics for next-generation disease management
Posted on Fri, Feb 25, 2022 @ 02:47 PM
Updated : Tue, March 21, 2023 @ 3:44 PM
This is the first blog post in a two-part series exploring how oligonucleotide...
Society can’t handle the caveats to each type of COVID-19 test
Posted on Fri, Feb 11, 2022 @ 04:58 PM
Updated : Fri, February 11, 2022 @ 10:58 PM
But measurement science could help steer us in a better, more informed...
Oligo synthesis and modifications
Leveraging quenching efficiency of Black Hole Quencher dyes for PCR and beyond
Posted on Tue, Jan 25, 2022 @ 02:30 PM
Updated : Tue, January 25, 2022 @ 8:30 PM
More innovative applications for Black Hole Quencher (BHQ) dyes
In imaging...
Five ways controls can demystify your Stellaris™ RNA FISH experiment
Posted on Sun, Jan 23, 2022 @ 06:14 AM
Updated : Wed, March 22, 2023 @ 1:23 PM
Stellaris controls, who needs ‘em? We all do. Especially if it’s your first...
Agrigenomics qPCR PCR-based genotyping
Increasing hybrid rice breeding efficiency with high-throughput genotyping
Posted on Tue, Jan 18, 2022 @ 03:03 PM
Updated : Thu, January 12, 2023 @ 5:10 PM
Rice is the primary staple for more than half the world's population.1 With...
Pandemic reflections: in the face of SARS-CoV-2 variants, COVID-19 testing remains essential
Posted on Tue, Jan 11, 2022 @ 12:00 PM
Updated : Tue, January 11, 2022 @ 6:00 PM
What’s changed for clinical labs as we enter the third year of COVID-19...
Pandemic reflections: unprecedented demand drives COVID-19 test developers to get creative
Posted on Tue, Dec 28, 2021 @ 09:30 AM
Updated : Tue, December 28, 2021 @ 3:30 PM
What’s changed for clinical labs as we enter the third year of COVID-19...
Molecular diagnostics SARS-CoV-2
Technical bulletin: Omicron impact on SARS-CoV-2 mutation analysis and investigation
Posted on Thu, Dec 23, 2021 @ 11:45 AM
Updated : Wed, March 22, 2023 @ 2:01 PM
The emergence of the Omicron lineage has quickly escalated to be a variant of...
Pandemic reflections: the world is short staffed
Posted on Tue, Dec 21, 2021 @ 06:52 PM
Updated : Thu, March 9, 2023 @ 5:39 PM
What’s changed for clinical labs as we enter the third year of COVID-19 testing?
Oligo synthesis and modifications
Oligonucleotide synthesis basics: Key takeaways for post-synthesis processing
Posted on Thu, Dec 16, 2021 @ 04:39 PM
Updated : Wed, December 14, 2022 @ 4:45 PM
This is the final blog post in a three-part educational series about best...
Molecular diagnostics SARS-CoV-2
Ensuring our diagnostic assays detect the Omicron variant
Posted on Thu, Dec 09, 2021 @ 04:24 PM
Updated : Fri, December 10, 2021 @ 2:34 AM
On 22 November 2021, The Network for Genomics Surveillance in South Africa...
Agrigenomics Next generation sequencing (NGS) NGS-based genotyping
A targeted GBS technology for all breeding communities
Posted on Tue, Dec 07, 2021 @ 04:11 PM
Updated : Tue, December 7, 2021 @ 10:11 PM
The decisions made by molecular breeding programmes have a substantial...
Extensions to the IVDR - what diagnostics manufacturers and suppliers need to know
Posted on Thu, Dec 02, 2021 @ 05:25 PM
We're excited to announce that the proposal to extend certain key provisions of the In Vitro Diagnostic Regulation... |
Molecular diagnostics SARS-CoV-2 Disease detection
Streamlining diagnostic workflows for common respiratory diseases, such as SARS-CoV-2, influenza and RSV
Posted on Tue, Nov 30, 2021 @ 04:29 PM
Updated : Tue, November 30, 2021 @ 10:29 PM
A fourth wave of COVID-19 has already emerged in many countries and a newly...
Agrigenomics NGS-based genotyping
NGS solutions for polyploid plant breeding challenges
Posted on Tue, Nov 23, 2021 @ 09:00 AM
Updated : Fri, June 30, 2023 @ 2:19 PM
Many cultivated crops with agronomic significance, including wheat, peanut, oat,...
Molecular diagnostics Oligo synthesis and modifications
Innovative applications for Black Hole Quencher dyes
Posted on Tue, Nov 16, 2021 @ 04:14 PM
Updated : Tue, January 25, 2022 @ 10:23 PM
This is the first blog post in a two-part series highlighting how Black Hole...
Oligo synthesis and modifications
Oligonucleotide synthesis basics: 4 key takeaways for in-house oligo production
Posted on Tue, Nov 02, 2021 @ 11:41 AM
Updated : Wed, December 14, 2022 @ 4:43 PM
This is the second blog post in a three-part educational series about best...
Molecular diagnostics SARS-CoV-2
Technical bulletin: SARS-CoV-2 mutation analysis and investigation
Posted on Thu, Oct 14, 2021 @ 05:01 PM
Updated : Thu, October 14, 2021 @ 10:01 PM
SARS-CoV-2 mutations and associated new variants are being reported...
8 qPCR amplification plot questions answered
Posted on Thu, Sep 30, 2021 @ 10:00 AM
Updated : Thu, February 3, 2022 @ 6:10 PM
When results from your qPCR assays aren’t quite what you expected, it can be...
Molecular diagnostics qPCR SARS-CoV-2
Can COVID-19 testing be made more sustainable during prolonged uncertainty?
Posted on Mon, Sep 27, 2021 @ 02:36 PM
Updated : Thu, March 31, 2022 @ 3:24 PM
In September 2021, Delta persists as the most prevalent variant worldwide1 due...
The surprising global impacts of Europe's In Vitro Diagnostic Regulation (IVDR)
Posted on Thu, Sep 16, 2021 @ 12:15 PM
Updated : Wed, September 15, 2021 @ 4:40 AM
A shortcut to understanding how to prepare for IVDR
In today’s global...
Oligo synthesis and modifications
Oligonucleotide synthesis basics: Introduction to phosphoramidite chemistry
Posted on Tue, Sep 14, 2021 @ 02:00 PM
Updated : Wed, December 14, 2022 @ 4:43 PM
This is the first blog post in a three-part educational series about best...
Agrigenomics PCR-based genotyping Nucleic acid extraction
4 steps to optimise sample collection for aquaculture genotyping
Posted on Tue, Sep 07, 2021 @ 02:59 PM
Updated : Tue, September 7, 2021 @ 7:59 PM
Aquaculture breeding programmes adopt genomic technologies, including...
Molecular diagnostics SARS-CoV-2
Tips for early-stage MDx companies launching new tests during COVID-19 times
Posted on Thu, Sep 02, 2021 @ 02:00 PM
Updated : Wed, November 9, 2022 @ 8:20 PM
The COVID-19 pandemic brought tremendous change to the molecular diagnostics...
Wastewater surveillance: a critical tool in pandemic management
Posted on Tue, Aug 31, 2021 @ 09:48 AM
Updated : Thu, September 29, 2022 @ 7:57 PM
As SARS-CoV-2 variants continue to threaten public health, officials are...
Technical bulletin: Emerging SARS-CoV-2 mutations and their effect on the immune response
Posted on Wed, Aug 18, 2021 @ 03:45 PM
Updated : Thu, December 16, 2021 @ 6:46 PM
Emerging SARS-CoV-2 variants of concern and variants of interest are defined...
Agrigenomics Next generation sequencing (NGS) Nucleic acid extraction
The importance of sample processing for successful plant genotyping by NGS
Posted on Thu, Aug 12, 2021 @ 06:51 PM
Updated : Thu, August 12, 2021 @ 11:51 PM
Informed plant breeding decisions help drive the field of agrigenomics...
Agrigenomics Nucleic acid extraction
Don't underestimate the complexity of your sample composition
Posted on Wed, Aug 04, 2021 @ 04:34 PM
Updated : Wed, August 4, 2021 @ 9:34 PM
A common mistake when initiating an agrigenomics project is failing to consider...
Selective breeding in aquaculture: advancing breeding programmes through genomics
Posted on Wed, Jun 09, 2021 @ 11:15 AM
Updated : Wed, December 14, 2022 @ 1:44 PM
The global demand for fish and fish products continues to increase as...
Molecular diagnostics Genomics SARS-CoV-2
Genomic surveillance: 3 techniques to detect and characterise SARS-CoV-2 variants
Posted on Wed, May 19, 2021 @ 11:34 AM
Updated : Thu, March 9, 2023 @ 5:37 PM
As the global population gains greater access to vaccines for COVID-19,...
Molecular diagnostics SARS-CoV-2
How do SARS-CoV-2 variants affect PCR assays for COVID-19 testing?
Posted on Tue, May 04, 2021 @ 11:03 AM
Updated : Thu, March 9, 2023 @ 5:34 PM
Researchers have identified several variants of SARS-CoV-2 since they sequenced...
Agrigenomics Genomics NGS-based genotyping
Best practices for implementing targeted genotyping by sequencing
Posted on Wed, Dec 02, 2020 @ 10:53 AM
Updated : Fri, November 20, 2020 @ 5:16 PM
In breeding programmes, selections based on a single or small number of...
Molecular diagnostics Genomics SARS-CoV-2
Building resilience into SARS-CoV-2 testing workflows: considerations for choosing an RNA isolation method
Posted on Wed, Oct 21, 2020 @ 11:00 AM
Updated : Thu, February 3, 2022 @ 4:39 PM
Clinical and diagnostic labs worldwide are still experiencing supply chain...
How high-throughput genotyping automation and KASP marker libraries connect research labs with commercial breeders to accelerate crop improvement
Posted on Wed, Oct 07, 2020 @ 11:31 AM
Updated : Wed, October 7, 2020 @ 4:33 PM
“In July of 2015, I was a member of the radish genome project team. My task...
Agrigenomics Genomics PCR-based genotyping
Employee spotlight: Meet Darshna "Dusty" Vyas
Posted on Mon, Sep 14, 2020 @ 10:15 AM
Updated : Fri, September 11, 2020 @ 9:52 PM
Darshna "Dusty" Vyas has been a Senior Scientist at LGC specialising in...
Molecular diagnostics Genomics SARS-CoV-2
Pressing COVID-19 testing issues of today and the near future
Posted on Wed, Aug 26, 2020 @ 09:57 AM
Updated : Tue, October 6, 2020 @ 6:45 PM
Following up with the panelists from our recent COVID-19 webinar, Part 3 of 3
...
Molecular diagnostics Genomics SARS-CoV-2
Sensitivity and accuracy in COVID-19 testing
Posted on Wed, Aug 19, 2020 @ 09:56 AM
Updated : Tue, October 6, 2020 @ 6:42 PM
Following up with the panelists from our recent COVID-19 webinar, Part 2 of 3
...
Molecular diagnostics Genomics SARS-CoV-2
Scaling up COVID-19 viral testing
Posted on Wed, Aug 12, 2020 @ 09:47 AM
Updated : Tue, October 6, 2020 @ 6:45 PM
Following up with the panelists from our recent COVID-19 webinar, Part 1 of 3
...
Molecular diagnostics Genomics qPCR SARS-CoV-2
Enabling a rapid response to COVID-19 by Honeywell and LGC, Biosearch Technologies
Posted on Wed, Jul 29, 2020 @ 02:40 PM
Updated : Tue, October 6, 2020 @ 6:44 PM
As countries worldwide begin to ease lockdown restrictions during the pandemic...
Agrigenomics Genomics PCR-based genotyping
Establishment of KASP marker library for genetic diversity analysis in Brassica rapa crops
Posted on Tue, Jul 14, 2020 @ 10:17 AM
Updated : Tue, July 14, 2020 @ 1:30 PM
Brassica rapa crops are important sources of food, feed, and fuel in many parts...
Molecular diagnostics Genomics qPCR SARS-CoV-2
Robust supply chains and open testing systems: How our AgBio roots meet the FDA's EUA process to enable solutions to the COVID-19 pandemic
Posted on Tue, May 19, 2020 @ 10:18 AM
Updated : Fri, December 18, 2020 @ 8:49 PM
It may seem strange that a company known for transforming the global seed...
Molecular diagnostics Oligo synthesis and modifications Genomics SARS-CoV-2
Behind the scenes: How our oligo synthesis team contributes to the reliability of your assays
Posted on Thu, Apr 30, 2020 @ 04:13 PM
Updated : Wed, March 22, 2023 @ 1:52 PM
We’re not rejecting you, just your oligo
PCR is arguably one of the most...
Molecular diagnostics SARS-CoV-2
When you don’t need an EUA for SARS-CoV-2 testing
Posted on Fri, Apr 10, 2020 @ 05:00 PM
Updated : Wed, November 25, 2020 @ 8:23 PM
On March 25, 2020, the US Food and Drug Administration (FDA) held the first...
Genomics Next generation sequencing (NGS) NGS-based genotyping
New NGS service lab now open in Middleton, WI for expanded global support
Posted on Wed, Apr 01, 2020 @ 11:27 AM
Updated : Wed, April 1, 2020 @ 8:12 PM
Back in September 2018, LGC acquired Lucigen Corporation. The ISO accredited...
Molecular diagnostics Oligo synthesis and modifications Genomics SARS-CoV-2
Addressing COVID-19 together: LGC, Biosearch Technologies and Shanghai Liferiver Biotechnology Co., Ltd.
Posted on Tue, Mar 31, 2020 @ 12:13 PM
Updated : Tue, October 6, 2020 @ 6:44 PM
In the nearly three months since the first confirmed case of COVID-19, the...
Molecular diagnostics Genomics SARS-CoV-2
What diagnostic test makers and CLIA labs in the US need to know about Emergency Use Authorization (EUA)
Posted on Tue, Mar 24, 2020 @ 01:58 PM
Updated : Tue, March 21, 2023 @ 3:41 PM
*Since the original publication of this blog, LGC Biosearch Technologies is now...
Molecular diagnostics Genomics SARS-CoV-2
Coronavirus outbreak: Collaboration to meet the challenge
Posted on Mon, Mar 16, 2020 @ 02:30 PM
Molecular diagnostics Next generation sequencing (NGS)
Molecular diagnostics: how can NGS live up to its promises?
Posted on Wed, Jan 29, 2020 @ 11:37 AM
Updated : Tue, October 11, 2022 @ 8:43 PM
The development of new genomic sequencing techniques and bioinformatics...
Genomics PCR-based genotyping NGS-based genotyping
Back to basics - the crucial step of sample collection
Posted on Wed, Jan 15, 2020 @ 11:37 AM
Updated : Mon, January 13, 2020 @ 5:08 PM
Best practice in sample collection for SeqSNP targeted genotyping by...
Agrigenomics Genomics Next generation sequencing (NGS) NGS-based genotyping
Genomic selection: can it accelerate livestock breeding?
Posted on Wed, May 01, 2019 @ 10:44 AM
Updated : Wed, May 1, 2019 @ 3:59 PM
Livestock supports the livelihoods and food security of almost 1.3 billion people...
The women of LGC, Biosearch Technologies
Posted on Fri, Mar 29, 2019 @ 11:24 AM
Updated : Fri, March 29, 2019 @ 4:39 PM
We've heard it said for years, "TV will rot your brain". But in the case of our...
Agrigenomics PCR-based genotyping Next generation sequencing (NGS) NGS-based genotyping
Agrigenomics: how can NGS contribute to global food security?
Posted on Wed, Mar 06, 2019 @ 10:33 AM
Updated : Fri, May 19, 2023 @ 8:53 AM
“Experience of artificial fertilisation, such as is effected with ornamental...
Agrigenomics Next generation sequencing (NGS) NGS-based genotyping
How targeted GBS-driven genomic selection can help you get to market faster
Posted on Wed, Jan 16, 2019 @ 01:22 PM
Updated : Thu, May 25, 2023 @ 11:32 AM
Plant and animal breeding programmes often take generations to improve quality...
Genomic selection: methods in crop and animal breeding
Posted on Wed, Jan 09, 2019 @ 10:48 AM
Updated : Wed, January 9, 2019 @ 5:03 PM
Genomic selection: 6 factors to consider when choosing between targeted GBS...
Agrigenomics Next generation sequencing (NGS) NGS-based genotyping
Our hungry planet: new tools in agrigenomics are key to food security
Posted on Tue, Dec 11, 2018 @ 10:32 AM
Updated : Tue, December 11, 2018 @ 4:32 PM
Food security is a major global threat and traditional methods of plant and...
Accelerating rice improvement in South Asia
Posted on Thu, Jul 26, 2018 @ 11:26 AM
Updated : Thu, July 26, 2018 @ 4:41 PM
Diversity is the spice of life and is also key to breeding rice that delivers...
Revolutionising cancer treatment one Array at a time
Posted on Tue, Jul 10, 2018 @ 11:05 AM
Updated : Mon, September 19, 2022 @ 2:14 PM
While the science of pharmacogenomics has been around for years, its...
Genomics Nucleic acid extraction
Pack it up, pack it in, let me begin: A look at the future of DNA data storage
Posted on Thu, Jun 28, 2018 @ 11:13 AM
Updated : Thu, June 28, 2018 @ 4:28 PM
Imagine a time capsule the size of a shoebox that holds all the information...
Warning! Pitfalls ahead: How to avoid the most common Stellaris RNA FISH mistakes
Posted on Tue, May 29, 2018 @ 10:32 AM
Updated : Tue, May 29, 2018 @ 3:47 PM
Ever wake up in the morning just feeling like a rock star, or maybe like Francis...
Shining a light on gene expression and regulation one cell at a time
Posted on Thu, Apr 19, 2018 @ 12:51 PM
Updated : Mon, April 30, 2018 @ 1:53 PM
To truly understand complex diseases such as cancer, scientists need access to...
The Women of LGC
Posted on Thu, Mar 29, 2018 @ 10:45 AM
Updated : Thu, March 29, 2018 @ 4:00 PM
Ask any little girl what they want to be when they grow up and you may hear...
In case you missed it: Stellaris RNA FISH lunch-and-learn
Posted on Tue, Jan 16, 2018 @ 10:35 AM
Updated : Tue, January 16, 2018 @ 4:50 PM
Stellaris® RNA FISH (fluorescence in situ hybridization) is an RNA...
Agrigenomics Genomics NGS-based genotyping
Tackling food crisis through cost effective, target enriched sequencing
Posted on Wed, Dec 13, 2017 @ 10:07 AM
Updated : Mon, September 19, 2022 @ 2:16 PM
With the global population predicted to reach 9 billion people within the...
Agrigenomics Genomics PCR-based genotyping
New SNPs identified in the hunt for new genetic weapons targeting leaf rust in wheat
Posted on Tue, Nov 21, 2017 @ 11:25 AM
Updated : Wed, November 22, 2017 @ 1:44 PM
Wheat is one of the three most important crops for human and livestock feed....
Agrigenomics Genomics PCR-based genotyping
Super-crops helping to feed Africa
Posted on Fri, Nov 03, 2017 @ 11:08 AM
Updated : Tue, July 10, 2018 @ 9:08 PM
Our world population is growing at a tremendous rate and by 2050, Africa’s...
Genomics PCR-based genotyping Disease detection
How genotyping is aiding in the fight against malaria
Posted on Wed, Sep 20, 2017 @ 10:11 AM
Updated : Mon, September 19, 2022 @ 2:14 PM
3.2 billion people across 106 countries and territories, live in areas at...
Lunch & Learn: Stellaris RNA FISH
Posted on Thu, Jul 06, 2017 @ 10:07 AM
Updated : Thu, July 6, 2017 @ 3:22 PM
Recently LGC Genomics hosted a lunch and learn Stellaris® seminar at the Helen...
It’s official! Personal Health becomes first China demonstration laboratory site for LGC’s Nexar System
Posted on Wed, May 03, 2017 @ 09:05 AM
Updated : Mon, September 19, 2022 @ 2:07 PM
LGC's Genomics Division has signed a memorandum of understanding (MOU) with...
Digital PCR – improving reproducible molecular methods in the clinic
Posted on Thu, Apr 06, 2017 @ 10:40 AM
Shining a light on how Zika virus may spread from mothers to human fetuses
Posted on Mon, Mar 06, 2017 @ 10:37 AM
Updated : Mon, March 6, 2017 @ 4:37 PM
New research has, for the first time, found evidence suggesting the molecular...
Water – Back to Basics for Thermal Cycling
Posted on Tue, Feb 28, 2017 @ 10:13 AM
Updated : Mon, September 19, 2022 @ 2:20 PM
It’s time to forget what you know about heating your PCR plates for...
Overcoming drought-intolerance in maize to feed the growing Asian population
Posted on Wed, Feb 15, 2017 @ 09:53 AM
Updated : Wed, February 15, 2017 @ 4:23 PM
Demand for maize is increasing due to an increased number of people...
Automate to Accelerate and Scale-up SNP-based Genotyping Workflows!
Posted on Thu, Feb 02, 2017 @ 09:14 AM
Updated : Mon, September 19, 2022 @ 2:05 PM
The advent of and ongoing improvements to next-generation sequencing...
Multiple Misunderstandings: Learning from Genetic Determinism
Posted on Mon, Jan 23, 2017 @ 10:12 AM
Updated : Mon, January 23, 2017 @ 4:27 PM
Nature versus nurture. It’s a tale as old as time.
When Craig Venter made the...
Agrigenomics Genomics PCR-based genotyping NGS-based genotyping
Helping to Feed the World with Genotyping by Sequencing
Posted on Tue, Jan 17, 2017 @ 09:42 PM
Updated : Wed, January 18, 2017 @ 2:13 PM
Many areas critical to improved agricultural production require robust and...
Faster, stronger, quicker: SSR to KASP will get you there
Posted on Mon, Jan 09, 2017 @ 09:05 AM
Updated : Mon, January 9, 2017 @ 3:20 PM
Screen more markers faster and bring crops with superior traits to the market...
Multiplex your qPCR and Walk-away
Posted on Thu, Dec 15, 2016 @ 10:17 AM
Updated : Mon, September 19, 2022 @ 2:15 PM
It seems everyone wants to do more with less, and automate the process as...
A Stellar-is Year in the Making
Posted on Wed, Dec 07, 2016 @ 10:05 AM
Updated : Mon, September 19, 2022 @ 2:12 PM
It wouldn't be fair to close out 2016 without showcasing the stellar year...
Buddy Up: The Double Helix
Posted on Mon, Nov 28, 2016 @ 09:15 AM
Updated : Mon, November 28, 2016 @ 11:31 PM
The secret of life. That’s what Francis Crick and James Watson claimed they...
Genes, Proteins & DNA: Our Hereditary Software
Posted on Mon, Nov 21, 2016 @ 09:17 AM
Updated : Mon, November 21, 2016 @ 3:32 PM
In the early 1900s, scientists found that the function of genes was to make...
"X" Marks the Spot: A closer look at chromosomes
Posted on Mon, Nov 14, 2016 @ 09:28 AM
Updated : Wed, March 29, 2023 @ 10:51 AM
The strands of DNA in your cells are organized into pieces called chromosomes....
Excel Autocorrect Fails the Genomics Community - Are your Results Excellent or Excel-not?
Posted on Thu, Sep 08, 2016 @ 11:30 AM
Updated : Mon, September 19, 2022 @ 2:13 PM
Researchers from the Baker IDI Heart and Diabetes Institute in Melbourne,...
qPCR-based molecular diagnostics at the forefront of Zika surveillance
Posted on Tue, Aug 23, 2016 @ 04:00 PM
Updated : Wed, March 29, 2023 @ 11:04 AM
As the Zika virus outbreak spreads, a wave of international concern has grown,...
Oligo synthesis and modifications
Know your oligo mod: Thio C6 linker
Posted on Thu, Jul 14, 2016 @ 04:00 PM
Updated : Wed, March 29, 2023 @ 10:55 AM
Thio C6 Linker (Thiohexyl)
We continue our “Know Your Oligo Mod” series with...
A Complete Ecosystem to Accelerate Breeding Programs [Infographic]
Posted on Tue, Jun 28, 2016 @ 04:00 PM
Updated : Tue, June 28, 2016 @ 9:00 PM
Modern breeding methods rely on the identification and utilization of molecular...
Molecular diagnostics Oligo synthesis and modifications qPCR
Photoblog: Behind the scenes of oligo synthesis
Posted on Wed, May 18, 2016 @ 05:00 PM
Updated : Wed, December 14, 2022 @ 5:04 PM
OLIGO SYNTHESIS PHOTO GLIMPSE
We’ve recently captured our talented...
Nova is the new black
Posted on Thu, Apr 14, 2016 @ 04:00 PM
Updated : Mon, April 24, 2023 @ 8:54 AM
LGC Biosearch Technologies has developed a new qPCR probe format powered by...
Learn about the latest developments in technologies for molecular breeding programs
Posted on Thu, Mar 31, 2016 @ 04:00 PM
Updated : Thu, March 31, 2016 @ 9:01 PM
At this year’s 24th annual Plant & Animal Genome (PAG) conference, LGC...
Imaging Stellaris Assays Part III: Creating Professional, Publication-ready Images
Posted on Thu, Mar 10, 2016 @ 04:00 PM
Updated : Wed, August 16, 2017 @ 9:15 AM
Here is the final installment of our “Imaging Stellaris Assays” blog series....
Designing Stellaris RNA FISH Probes Part I: Increasing Probe Count
Posted on Thu, Jan 14, 2016 @ 04:00 PM
Updated : Tue, September 27, 2022 @ 2:32 PM
Stellaris® RNA FISH is a novel technology that allows for the detection of...
Oligo synthesis and modifications qPCR
Know your oligo mod: 3' Spacer C3
Posted on Thu, Oct 15, 2015 @ 04:15 PM
Updated : Wed, March 29, 2023 @ 10:54 AM
This week, we continue our Know your oligo mod blog series and we will focus...
Imaging Stellaris Assays Part II: How to Acquire Stunning Images
Posted on Thu, Sep 24, 2015 @ 04:30 PM
Updated : Wed, August 16, 2017 @ 9:13 AM
Here we continue our “Imaging Stellaris Assays” blog series. We last left off...
Runaway RNA Stays Put
Posted on Thu, Sep 17, 2015 @ 04:00 PM
Updated : Tue, March 21, 2023 @ 3:53 PM
The cleavage and polyadenylation event, the final trimming in the molecular...
Imaging Stellaris Assays Part I: Get to Know Your Microscope
Posted on Thu, Aug 27, 2015 @ 07:00 PM
Updated : Wed, August 16, 2017 @ 9:42 PM
Stellaris® FISH is an RNA detection technology performed by means of in situ...
Oligo synthesis and modifications
The AGCT’s of DNA synthesis
Posted on Tue, Aug 11, 2015 @ 04:00 PM
Updated : Wed, March 29, 2023 @ 10:38 AM
Chemically synthesized DNA has become an indispensable tool for molecular...
Oligo synthesis and modifications
Know your oligo mod: BHQ (Black Hole Quencher) non-fluorescent quenchers
Posted on Thu, Jul 23, 2015 @ 04:00 PM
Updated : Fri, January 13, 2023 @ 11:35 AM
In this instalment, we will cover the basics of LGC Biosearch Technologies’...
And the Consensus (Sequence) is...
Posted on Thu, Jun 11, 2015 @ 04:31 PM
Updated : Fri, November 13, 2015 @ 9:25 PM
Studying the expression level of RNA transcripts is often complicated by the...
Research Highlight: Bringing Vision Research into Focus
Posted on Thu, May 28, 2015 @ 04:14 PM
Updated : Tue, March 21, 2023 @ 3:37 PM
Gene expression and molecular biology research in vision and ophthalmology...
FISH-ing for Fusions: A unique approach to fusion gene mRNA & pre-mRNA detection in cancer
Posted on Fri, May 15, 2015 @ 03:00 PM
Updated : Fri, November 13, 2015 @ 10:27 PM
This past April, Biosearch attended the American Association of Cancer...
How Much is Your qPCR Assay Really Costing You?
Posted on Thu, Apr 02, 2015 @ 04:00 PM
Updated : Fri, November 13, 2015 @ 10:40 PM
In the setup of a qPCR experiment, one of the first decisions to make is...
The 4Cs of Stellaris® RNA FISH Buffers
Posted on Thu, Feb 26, 2015 @ 04:00 PM
Updated : Mon, November 16, 2015 @ 3:55 PM
Buffers are often overlooked and taken for granted until the day comes when...
Oligo synthesis and modifications
Know your oligo mod: phosphorothioate bonds
Posted on Thu, Feb 12, 2015 @ 04:00 PM
Updated : Wed, March 29, 2023 @ 10:56 AM
As part of our “Know your oligo mod” blog series, we cover phosphorothioate...
Optimising multiplex competitive qRT-PCR in diagnostics with BHQplus probes
Posted on Thu, Jan 29, 2015 @ 04:00 PM
Updated : Mon, November 16, 2015 @ 5:30 PM
In a webinar linked below, Dr. James Willey describes a two colour...
A Successful Duo for Accurate, Speedy, and Economical SNP Genotyping
Posted on Thu, Jan 08, 2015 @ 01:30 PM
Updated : Mon, September 19, 2022 @ 2:12 PM
Single Nucleotide Polymorphisms (SNPs) have been widely studied for over 15...
Oligo synthesis and modifications
Know your oligo mod: Methylene Blue
Posted on Tue, Dec 09, 2014 @ 04:02 PM
Updated : Wed, March 29, 2023 @ 10:56 AM
The chemical synthesis of oligonucleotides allows for the incorporation of a...
Unraveling the Neural Web: Stellaris® RNA FISH for Neuroscience Research
Posted on Thu, Nov 13, 2014 @ 05:45 PM
Updated : Mon, September 19, 2022 @ 2:14 PM
Neuroscience gene expression research can come with many hurdles,...
Check out our new website qPCR Design Lab @ qPCRdesign.com
Posted on Thu, Oct 23, 2014 @ 04:00 PM
Updated : Tue, March 28, 2023 @ 9:02 PM
Biosearch Technologies has launched qPCRdesign.com, a microsite targeted...
Oligo synthesis and modifications qPCR
Delivering Oligos by Nanomole Units
Posted on Wed, Oct 15, 2014 @ 01:00 PM
Updated : Tue, October 14, 2014 @ 10:21 PM
Different oligonucleotide manufacturers deliver probes and primers in a...
RT-qPCR Molecular Diagnostics Assist Workers at the Forefront of Ebola Outbreak.
Posted on Thu, Sep 25, 2014 @ 01:30 PM
Updated : Mon, September 19, 2022 @ 2:13 PM
The largest recorded Ebola Virus Disease outbreak in history continues to...
One step too many? Simplify your qPCR protocol
Posted on Thu, Feb 27, 2014 @ 12:02 PM
Updated : Mon, September 19, 2022 @ 2:12 PM
Don’t waste time performing an extra step. Cut back on pipetting and order...
30 Years: The Impact of PCR
Posted on Thu, Sep 05, 2013 @ 11:29 AM
Updated : Tue, March 21, 2023 @ 3:52 PM
Do you remember when the most popular method of DNA amplification involved...
RT-qPCR and the Stellaris FISH Method
Posted on Fri, Apr 26, 2013 @ 12:32 PM
Updated : Mon, September 19, 2022 @ 2:10 PM
A "Referral from the Doctor" Blog Article-
Quantitative reverse...
Biosearch Technologies Responds To China Influenza H7N9 Outbreak By Providing H7N9 Detection Panel
Posted on Mon, Apr 15, 2013 @ 08:00 AM
Updated : Mon, September 19, 2022 @ 2:13 PM
Biosearch Technologies, Inc. (Biosearch) announced today that the company...
Stellaris® Foundation Genes: GAPDH
Posted on Thu, Apr 11, 2013 @ 11:30 AM
Updated : Wed, October 1, 2014 @ 4:53 PM
Stellaris probe sets targeting glyceraldehyde-3-phosphate dehydrogenase...
Biosearch Technologies, UMDNJ Stellaris® Probe Alliance - NextGen Gene Expression™, SNP FISH™, and iceFISH™ in Research and Clinical Applications
Posted on Mon, Mar 18, 2013 @ 10:43 AM
Updated : Mon, September 19, 2022 @ 2:07 PM
Biosearch Technologies, Inc. (Biosearch), a leading supplier of...
Biosearch Technologies Announces Acquisition of European Companies DNA Technology and VitraBio
Posted on Thu, Feb 21, 2013 @ 08:00 AM
Updated : Wed, October 1, 2014 @ 4:53 PM
Biosearch Technologies, Inc. (Biosearch), a leading supplier of...
Biosearch Technologies Launches Catalogued Stellaris™ RNA FISH Assays
Posted on Mon, Jun 18, 2012 @ 10:08 AM
Updated : Mon, September 19, 2022 @ 2:07 PM
Biosearch Technologies, Inc. (Biosearch), a leading supplier of...
Single molecule viral RNA analysis using Stellaris™ FISH technology
Posted on Wed, May 30, 2012 @ 03:00 PM
Image courtesy of: http://www.cdc.gov/h1n1flu/images.htm |
Updated : Mon, September 19, 2022 @ 2:13 PM
A...
qPCR Probes at work: Innovative CLIA test for NSCLC staging
Posted on Tue, Mar 06, 2012 @ 01:00 PM
Updated : Wed, October 1, 2014 @ 4:51 PM
Non-squamous, Non-small cell lung cancer (NSCLC), the most common cause of...
Factors affecting fluorophore performance in qPCR
Posted on Wed, Jan 11, 2012 @ 11:00 AM
Updated : Fri, October 21, 2022 @ 10:24 AM
Fluorophores are molecules that can absorb light energy in a process called...
The 'Monte Carlo' Effect in qPCR
Posted on Wed, Nov 09, 2011 @ 01:00 PM
Updated : Mon, September 19, 2022 @ 2:10 PM
A "Referral from the Doctor" Blog Article-
The mathematical model of PCR...
Fluorescence Quenching Mechanisms for Dual-Labeled Probes
Posted on Wed, Jun 29, 2011 @ 09:44 AM
Updated : Mon, September 19, 2022 @ 2:10 PM
A "Referral from the Doctor" Blog Article-
Fluorescent probes are used in...
Multiplexing with Xanthenes
Posted on Wed, Jun 08, 2011 @ 11:13 AM
Updated : Mon, September 19, 2022 @ 2:10 PM
A "Referral from the Doctor" Blog Article-
Quantitative real-time PCR...
qPCR troubleshooting: interpreting amplification curves and diagnosing problems
Posted on Thu, May 05, 2011 @ 12:15 PM
Updated : Thu, May 11, 2023 @ 10:06 AM
If you run quantitative real-time PCR (qPCR) assays, the chances are that...
Between ROX and a Hard Place
Posted on Wed, Nov 10, 2010 @ 11:12 AM
Updated : Mon, September 19, 2022 @ 2:10 PM
A "Referral from the Doctor" Blog Article-
ROX in qPCR
Quantitative...
Visit Biosearch at IVD Technology's Virtual Conference and Tradeshow
Posted on Thu, Sep 23, 2010 @ 04:32 PM
Updated : Mon, September 19, 2022 @ 2:07 PM
Biosearch Technologies is proud to sponsor the first IVD Technology...
PilotDx Oligos: En Route to IVD
Posted on Thu, Jul 22, 2010 @ 10:07 AM
Updated : Wed, October 1, 2014 @ 4:42 PM
It can be difficult to transition a product from research to...
Pipetting for qPCR
Posted on Wed, Jun 09, 2010 @ 10:41 AM
Updated : Mon, September 19, 2022 @ 2:14 PM
A "Referral from the Doctor" Blog Article-
Research trends in laboratories...
Killer probes for qPCR: what is a Scorpions Primer?
Posted on Wed, Mar 24, 2010 @ 10:57 AM
Updated : Thu, March 23, 2023 @ 11:57 AM
Scorpions™ Primers are dual-labeled FRET probes that combine a Molecular...
A light in the storm: what is a Molecular Beacon?
Posted on Wed, Mar 10, 2010 @ 12:00 PM
Updated : Mon, March 20, 2023 @ 9:54 PM
Molecular Beacons are a special type of dual-labeled oligonucleotide probe....
Dual-labeled BHQ probes - Performance to “dye” for
Posted on Wed, Feb 24, 2010 @ 12:20 PM
Updated : Mon, September 19, 2022 @ 2:10 PM
A BHQ® probe is a dual-labeled...
This Year's MVP (Most Valuable Practice): Touchdown PCR
Posted on Thu, Feb 04, 2010 @ 12:39 PM
Updated : Mon, September 19, 2022 @ 2:10 PM
A "Referral from the Doctor" Blog Article-
The aim of the Polymerase...
The Grand Ballet: Wine and Biotechnology
Posted on Wed, Jan 27, 2010 @ 01:15 PM
Updated : Wed, October 1, 2014 @ 4:38 PM
Alternative to DNAse I heat inactivation
Posted on Wed, Jan 13, 2010 @ 12:04 PM
Updated : Wed, December 14, 2022 @ 4:20 PM
A "Referral from the Doctor" Blog Article-
Genomic DNA contamination has...
A Quick Jump Start to Multiplexing qPCR
Posted on Wed, Jan 06, 2010 @ 12:01 PM
Updated : Thu, September 22, 2022 @ 5:16 PM
Slope Efficiency Equals Manageable and Corrected PCR
Posted on Wed, Dec 09, 2009 @ 02:01 PM
Updated : Mon, September 19, 2022 @ 2:10 PM
A "Referral from the Doctor" Blog Article-
ε = m.c.2 (shall I explain?...
Bringing Back a Champion: Competitive Quantitative Real-time RT-PCR
Posted on Wed, Nov 18, 2009 @ 10:08 AM
Updated : Mon, September 19, 2022 @ 2:10 PM
A "Referral from the Doctor" Blog Article-
Competitive qRT-PCR has become...
Oligo synthesis and modifications qPCR
RPLP0 housekeeping gene for normalising RT-PCR assays
Posted on Wed, Oct 14, 2009 @ 10:06 AM
Updated : 2 May 2024 @ 2:10 PM
Quantitative reverse transcription PCR (RT-qPCR) is commonly used to measure gene...
What Genes are Hot, What Genes are Not
Posted on Wed, Oct 07, 2009 @ 04:41 PM
Updated : Mon, September 19, 2022 @ 2:10 PM
A "Referral from the Doctor" Blog Article-
Top 10 Reference Genes for...
Oligo synthesis and modifications qPCR
Labeling oligonucleotides with internal BHQ dyes
Posted on Tue, Sep 29, 2009 @ 10:16 AM
Updated : Fri, January 13, 2023 @ 11:38 AM
When to use an internal Black Hole Quencher (BHQ) label in a...
Oligo synthesis and modifications qPCR
Salt-Free Primer Pair Option Now Available
Posted on Tue, Sep 22, 2009 @ 10:08 AM
Updated : Mon, September 19, 2022 @ 2:12 PM
Molecular diagnostics NGS-based genotyping Nucleic acid extraction
Our scientists and product specialists work in close collaboration with a diverse range of customers to find solutions that meet their precise needs. Our...
Genomics Nucleic acid therapeutics
Dozens of oligonucleotide-based therapeutics are already on the market, helping to treat a range of life-threatening conditions. As we explored in our previous...
Genomics Nucleic acid therapeutics
With the rapid deployment of the mRNA COVID-19 vaccines and the recent approval of the first CRISPR gene therapy, the range of oligonucleotide-based...
Molecular diagnostics Disease detection
Although PCR is often viewed as a gold standard for molecular diagnostic tests, the problem of non-specific primer interactions can seriously limit its speed...
Molecular diagnostics Disease detection
Detecting single nucleotide variations (SNVs) offers powerful actionable insights in diagnosing diseases, monitoring cancer progression and identifyingpathogen...
Molecular diagnostics Disease detection
Since Humira (adalimumab) became the first approved monoclonal antibody therapy developed using phage display in 2002, it has sold more than any other drug in...
Molecular diagnostics Genomics
Image credit: HIV Reverse Transcriptase. RCSB Protein Data Bank. The Wellcome Collection.
Disease detection Nucleic acid therapeutics
While RNA-based therapeutics are taking the biotechnology world by storm following the rapid development of the COVID-19 vaccines, the next generation of...
Oligo synthesis and modifications Nucleic acid therapeutics
Molecular diagnostics Disease detection
As the world scrambled to rapidly expand PCR testing capacity in 2020, it became increasingly clear that there was a need for cheaper, simpler, quicker...
Oligo synthesis and modifications Nucleic acid therapeutics
Molecular diagnostics Nucleic acid extraction
Updated : Fri, May 26, 2023 @ 10:18 AM
Designing a new assay and scaling it for commercial use takes thoughtful planning, foresight, and engagement with...
Updated : Tue, May 9, 2023 @ 11:03 AM
When it comes to oligonucleotide therapeutics, the challenge has always been how to deliver an intact oligo to the right...
Molecular diagnostics Oligo synthesis and modifications qPCR General science
Updated : Fri, May 5, 2023 @ 2:34 PM
How does a BHQ dye contribute to producing superior data from your assays?
Oligo synthesis and modifications Nucleic acid therapeutics
Updated : Mon, June 26, 2023 @ 10:24 AM
Oligonucleotide therapeutics have unlocked new treatment possibilities for rare and fatal diseases often associated...
Molecular diagnostics SARS-CoV-2 Disease detection
Updated : Tue, May 9, 2023 @ 10:57 AM
We were delighted to attend the Association for Molecular Pathology (AMP) 2022 annual meeting, held in Phoenix, Arizona...
Molecular diagnostics Oligo synthesis and modifications
Updated : Tue, May 9, 2023 @ 11:01 AM
Originally developed in the early 1990s, aptamers have long been heralded as an antibody alternative for detection...
Molecular diagnostics Nucleic acid extraction General science
Updated : Tue, May 9, 2023 @ 11:05 AM
Molecular testing protocols for pathogen detection and diagnosing human diseases require reliable and high-quality...
Oligo synthesis and modifications Nucleic acid therapeutics General science
Updated : Tue, August 9, 2022 @ 7:10 PM
New approaches that use aptamers as targeting agents may open the door to wider clinical use in the future
Molecular diagnostics Oligo synthesis and modifications qPCR General science
Updated : Tue, May 9, 2023 @ 10:40 AM
Let the application be your guide when deciding between LNA, MGB and BHQplus
The many different chemistries available...
Molecular diagnostics Disease detection
Updated : Thu, July 7, 2022
Since 13 May 2022, reports of monkeypox cases began to appear globally in regions not endemic to the monkeypox virus.1 As the...
SARS-CoV-2 Nucleic acid extraction Disease detection General science
Updated : Fri, December 16, 2022 @ 3:39 PM
Since early 2020, diagnostic laboratories have had to manage patient sample quantities being in a state of flux....
Updated : Tue, March 21, 2023 @ 3:23 PM
What’s changed for clinical labs as we enter the third year of COVID-19 testing?
COVID-19, the illness caused by...
Molecular diagnostics qPCR General science
Updated : Wed, March 30, 2022 @ 4:00 PM
While both centralised and decentralised molecular diagnostics (MDx) testing models play an important role in patient...
Oligo synthesis and modifications Nucleic acid therapeutics
Updated : Tue, March 21, 2023 @ 3:46 PM
This is the second blog in a two-part series exploring how oligonucleotide modifications can support the advancement of...
Molecular diagnostics qPCR General science
Updated : Fri, April 15, 2022 @ 8:58 PM
The COVID-19 pandemic has accelerated the uptake of point of care testing (POCT), with simple, user-administered tests...
Oligo synthesis and modifications Nucleic acid therapeutics
Updated : Tue, March 21, 2023 @ 3:44 PM
This is the first blog post in a two-part series exploring how oligonucleotide modifications can support the...
qPCR SARS-CoV-2 General science
Updated : Fri, February 11, 2022 @ 10:58 PM
But measurement science could help steer us in a better, more informed direction
COVID-19 tests can indicate the...
Updated : Tue, January 11, 2022 @ 6:00 PM
What’s changed for clinical labs as we enter the third year of COVID-19 testing?
COVID-19, the illness caused by...
Updated : Tue, December 28, 2021 @ 3:30 PM
What’s changed for clinical labs as we enter the third year of COVID-19 testing?
COVID-19, the illness caused by...
Molecular diagnostics SARS-CoV-2
Updated : Wed, March 22, 2023 @ 2:01 PM
The emergence of the Omicron lineage has quickly escalated to be a variant of concern by the World Health Organization -
Updated : Thu, March 9, 2023 @ 5:39 PM
What’s changed for clinical labs as we enter the third year of COVID-19 testing?
Molecular diagnostics SARS-CoV-2
Updated : Fri, December 10, 2021 @ 2:34 AM
On 22 November 2021, The Network for Genomics Surveillance in South Africa detected a new SARS-CoV-2 variant, named...
We're excited to announce that the proposal to extend certain key provisions of the In Vitro Diagnostic Regulation (IVDR) (EU) 2017/746 has been adopted... |
Molecular diagnostics SARS-CoV-2 Disease detection
Updated : Tue, November 30, 2021 @ 10:29 PM
A fourth wave of COVID-19 has already emerged in many countries and a newly classified variant of concern, Omicron...
Molecular diagnostics Oligo synthesis and modifications
Updated : Tue, January 25, 2022 @ 10:23 PM
This is the first blog post in a two-part series highlighting how Black Hole Quencher™ dyes can be incorporated into...
Molecular diagnostics SARS-CoV-2
Updated : Thu, October 14, 2021 @ 10:01 PM
SARS-CoV-2 mutations and associated new variants are being reported regularly in the media and scientific...
Molecular diagnostics qPCR SARS-CoV-2 General science
Updated : Thu, March 31, 2022 @ 3:24 PM
In September 2021, Delta persists as the most prevalent variant worldwide1 due to its high infectivity, causing surges...
Updated : Wed, September 15, 2021 @ 4:40 AM
A shortcut to understanding how to prepare for IVDR
In today’s global environment, even small regulatory changes in...
Molecular diagnostics SARS-CoV-2
Updated : Wed, November 9, 2022 @ 8:20 PM
The COVID-19 pandemic brought tremendous change to the molecular diagnostics (MDx) industry, delivering opportunities...
Updated : Thu, September 29, 2022 @ 7:57 PM
As SARS-CoV-2 variants continue to threaten public health, officials are looking beyond clinical tests to track...
Updated : Thu, December 16, 2021 @ 6:46 PM
Emerging SARS-CoV-2 variants of concern and variants of interest are defined by agencies such as the World Health...
Molecular diagnostics Genomics SARS-CoV-2 General science
Updated : Thu, March 9, 2023 @ 5:37 PM
As the global population gains greater access to vaccines for COVID-19, scientists and health officials continue to...
Molecular diagnostics SARS-CoV-2
Updated : Thu, March 9, 2023 @ 5:34 PM
Researchers have identified several variants of SARS-CoV-2 since they sequenced the original viral strain responsible...
Molecular diagnostics Genomics SARS-CoV-2 General science
Updated : Thu, February 3, 2022 @ 4:39 PM
Clinical and diagnostic labs worldwide are still experiencing supply chain challenges with their SARS-CoV-2 testing...
Molecular diagnostics Genomics SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:45 PM
Following up with the panelists from our recent COVID-19 webinar, Part 3 of 3
In the previous two blog posts in this...
Molecular diagnostics Genomics SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:42 PM
Following up with the panelists from our recent COVID-19 webinar, Part 2 of 3
In the face of a rapidly evolving...
Molecular diagnostics Genomics SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:45 PM
Following up with the panelists from our recent COVID-19 webinar, Part 1 of 3
The COVID-19 pandemic has presented...
Molecular diagnostics Genomics qPCR SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:44 PM
As countries worldwide begin to ease lockdown restrictions during the pandemic and prepare to return to “normal”...
Molecular diagnostics Genomics qPCR SARS-CoV-2
Updated : Fri, December 18, 2020 @ 8:49 PM
It may seem strange that a company known for transforming the global seed breeding industry is uniquely positioned...
Molecular diagnostics Oligo synthesis and modifications Genomics SARS-CoV-2 General science
Updated : Wed, March 22, 2023 @ 1:52 PM
We’re not rejecting you, just your oligo
PCR is arguably one of the most enabling technologies of modern molecular...
Molecular diagnostics SARS-CoV-2
Updated : Wed, November 25, 2020 @ 8:23 PM
On March 25, 2020, the US Food and Drug Administration (FDA) held the first of a series of virtual town halls they...
Molecular diagnostics Oligo synthesis and modifications Genomics SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:44 PM
In the nearly three months since the first confirmed case of COVID-19, the outbreak has become a global crisis, with...
Molecular diagnostics Genomics SARS-CoV-2 General science
Updated : Tue, March 21, 2023 @ 3:41 PM
*Since the original publication of this blog, LGC Biosearch Technologies is now the only acceptable commercial supplier...
Molecular diagnostics Genomics SARS-CoV-2
Molecular diagnostics Next generation sequencing (NGS)
Updated : Tue, October 11, 2022 @ 8:43 PM
The development of new genomic sequencing techniques and bioinformatics analysis in the last decade has led to...
Genomics PCR-based genotyping Disease detection General science
Updated : Mon, September 19, 2022 @ 2:14 PM
3.2 billion people across 106 countries and territories, live in areas at risk of malaria transmission. The serious...
RNA FISH Disease detection General science
Updated : Mon, March 6, 2017 @ 4:37 PM
New research has, for the first time, found evidence suggesting the molecular epidemiology of how the Zika virus spreads...
Molecular diagnostics Oligo synthesis and modifications qPCR General science
Updated : Wed, December 14, 2022 @ 5:04 PM
OLIGO SYNTHESIS PHOTO GLIMPSE
We’ve recently captured our talented manufacturing teams hard at work building...
Molecular diagnostics qPCR General science
Updated : Mon, September 19, 2022 @ 2:13 PM
The largest recorded Ebola Virus Disease outbreak in history continues to devastate the West African region. This...
Molecular diagnostics qPCR General science
Updated : Wed, October 1, 2014 @ 4:51 PM
Non-squamous, Non-small cell lung cancer (NSCLC), the most common cause of death in the US and globally, has recently...
Updated : Mon, September 19, 2022 @ 2:07 PM
Biosearch Technologies is proud to sponsor the first IVD Technology Virtual Conference and Tradeshow. This free...
Updated : Wed, October 1, 2014 @ 4:42 PM
It can be difficult to transition a product from research to commercialization. It’s simply not feasible to conduct...
Agrigenomics Next generation sequencing (NGS) Targeted GBS
By Austin Sheppe PhD, LGC Biosearch Technologies withcontributionsby Dusty Vyas, Senior Scientist LGC Biosearch Technologies.
Molecular diagnostics NGS-based genotyping Nucleic acid extraction
Our scientists and product specialists work in close collaboration with a diverse range of customers to find solutions that meet their precise needs. Our...
African forest elephants are considered a keystone species due to their positive impact on the forest ecosystem. As the largest frugivores on earth, they have...
qPCR PCR-based genotyping oligos probes and primers
Need high specificity and shorter probes for your hybridisation assays? If you are considering Minor Groove Binder (MGB) Probes for your applications, here are...
Sorghum[Sorghum bicolor (L.) Moench] is a diploid cereal crop used for food, drink (beer), livestock feed, fuel and as an environmentally friendly building...
Oligo synthesis and modifications qPCR NGS-based genotyping KASP CPG
Our scientists can’t agree!
Our portfolio covers a wide range of products supporting research, development and manufacturing across the life sciences,...
Creating a crop that is more effective at meeting the needs of farmers and end consumers is the aim of every plant breeder. Using a targeted genotyping by...
Agrigenomics Next generation sequencing (NGS) NGS-based genotyping
Potato (Solanum tuberosum) is the world’s third most important food crop after wheat and cereal and is a staple food for over 1.3 billion people. The overall...
Agrigenomics Next generation sequencing (NGS) NGS-based genotyping
How does genomic selection increase profitability?
Agrigenomics NGS-based genotyping
Every year over 1.5 million tonnes of blueberries and over half a million tonnes of cranberries are produced. This is expected to rise significantly over the...
Updated : Thu, June 1, 2023 @ 4:09 PM
Oil palm, Elaeis guineensis Jacq., is the most productive oil crop in the world1 supplying around 40% of all globally...
Agrigenomics PCR-based genotyping
Updated : Tue, May 9, 2023 @ 10:48 AM
Around 159,200 tonnes of strawberries are produced annually in Japan across 5,020 ha in various regions around the...
Agrigenomics PCR-based genotyping
Updated : Wed, March 22, 2023 @ 1:48 PM
Genotyping plants can be a complex and frustrating process
Agrigenomics PCR-based genotyping
Updated : Wed, March 22, 2023 @ 1:22 PM
Modern agriculture faces unprecedented challenges: increasing global temperatures, water scarcity, less arable land to...
Updated : Mon, April 17, 2023 @ 1:33 PM
This is the first blog in a two-part series exploring solutions for infectious diseases in aquaculture. This blog post...
Agrigenomics qPCR PCR-based genotyping General science
Updated : Wed, March 9, 2022 @ 1:05 AM
African oil palm (Elaeis guineensis Jacq.) is a highly productive perennial crop that is used widely in food, medicines,...
Agrigenomics qPCR PCR-based genotyping
Updated : Thu, January 12, 2023 @ 5:10 PM
Rice is the primary staple for more than half the world's population.1 With so many people relying on the crop for...
Agrigenomics Next generation sequencing (NGS) NGS-based genotyping
Updated : Tue, December 7, 2021 @ 10:11 PM
The decisions made by molecular breeding programmes have a substantial impact on the world around us, from...
Agrigenomics NGS-based genotyping
Updated : Fri, June 30, 2023 @ 2:19 PM
Many cultivated crops with agronomic significance, including wheat, peanut, oat, banana, potato, coffee, blueberry and...
Agrigenomics PCR-based genotyping Nucleic acid extraction
Updated : Tue, September 7, 2021 @ 7:59 PM
Aquaculture breeding programmes adopt genomic technologies, including genotyping, to increase genetic gain for...
Agrigenomics Next generation sequencing (NGS) Nucleic acid extraction
Updated : Thu, August 12, 2021 @ 11:51 PM
Informed plant breeding decisions help drive the field of agrigenomics towards ever-increasing agricultural...
Agrigenomics Nucleic acid extraction
Updated : Wed, August 4, 2021 @ 9:34 PM
A common mistake when initiating an agrigenomics project is failing to consider specific sample composition before...
Agrigenomics Genomics General science
Updated : Wed, December 14, 2022 @ 1:44 PM
The global demand for fish and fish products continues to increase as consumers focus on health-conscious ways to...
Agrigenomics Genomics NGS-based genotyping
Updated : Fri, November 20, 2020 @ 5:16 PM
In breeding programmes, selections based on a single or small number of markers to target traits in marker assisted...
Updated : Wed, October 7, 2020 @ 4:33 PM
“In July of 2015, I was a member of the radish genome project team. My task was to examine genetic diversity of radish...
Agrigenomics Genomics PCR-based genotyping
Updated : Fri, September 11, 2020 @ 9:52 PM
Darshna "Dusty" Vyas has been a Senior Scientist at LGC specialising in plant genetics for the past 8 years Her...
Agrigenomics Genomics PCR-based genotyping
Updated : Tue, July 14, 2020 @ 1:30 PM
Brassica rapa crops are important sources of food, feed, and fuel in many parts of the world and provide a unique...
Genomics Next generation sequencing (NGS) NGS-based genotyping
Updated : Wed, April 1, 2020 @ 8:12 PM
Back in September 2018, LGC acquired Lucigen Corporation. The ISO accredited site is based in Middleton, Wisconsin and...
Genomics PCR-based genotyping NGS-based genotyping
Updated : Mon, January 13, 2020 @ 5:08 PM
Best practice in sample collection for SeqSNP targeted genotyping by sequencing projects
When good goes in, great...
Agrigenomics Genomics Next generation sequencing (NGS) NGS-based genotyping
Updated : Wed, May 1, 2019 @ 3:59 PM
Livestock supports the livelihoods and food security of almost 1.3 billion people worldwide, contributing 40% of the...
Agrigenomics PCR-based genotyping Next generation sequencing (NGS) NGS-based genotyping
Updated : Fri, May 19, 2023 @ 8:53 AM
“Experience of artificial fertilisation, such as is effected with ornamental plants in order to obtain new variations in...
Agrigenomics Next generation sequencing (NGS) NGS-based genotyping
Updated : Thu, May 25, 2023 @ 11:32 AM
Plant and animal breeding programmes often take generations to improve quality and yield but using a genotyping protocol...
Updated : Wed, January 9, 2019 @ 5:03 PM
Genomic selection: 6 factors to consider when choosing between targeted GBS and microarrays
Agrigenomics Next generation sequencing (NGS) NGS-based genotyping
Updated : Tue, December 11, 2018 @ 4:32 PM
Food security is a major global threat and traditional methods of plant and animal breeding will not be sufficient...
Updated : Thu, July 26, 2018 @ 4:41 PM
Diversity is the spice of life and is also key to breeding rice that delivers increased yields. Rice is a crucial staple...
Agrigenomics Genomics NGS-based genotyping General science
Updated : Mon, September 19, 2022 @ 2:16 PM
With the global population predicted to reach 9 billion people within the next 35 years, we will need to double the...
Agrigenomics Genomics PCR-based genotyping
Updated : Wed, November 22, 2017 @ 1:44 PM
Wheat is one of the three most important crops for human and livestock feed. With an ever-increasing global...
Agrigenomics Genomics PCR-based genotyping
Updated : Tue, July 10, 2018 @ 9:08 PM
Our world population is growing at a tremendous rate and by 2050, Africa’s population alone is set to hit over 2.5...
Genomics PCR-based genotyping Disease detection General science
Updated : Mon, September 19, 2022 @ 2:14 PM
3.2 billion people across 106 countries and territories, live in areas at risk of malaria transmission. The serious...
Genomics PCR-based genotyping General science
Updated : Wed, February 15, 2017 @ 4:23 PM
Demand for maize is increasing due to an increased number of people transitioning to meat-based diets driving demand...
Agrigenomics Genomics PCR-based genotyping NGS-based genotyping General science
Updated : Wed, January 18, 2017 @ 2:13 PM
Many areas critical to improved agricultural production require robust and scalable genotyping platforms to enable...
Updated : Mon, January 9, 2017 @ 3:20 PM
Screen more markers faster and bring crops with superior traits to the market quicker.
Updated : Tue, June 28, 2016 @ 9:00 PM
Modern breeding methods rely on the identification and utilization of molecular markers associated with traits...
qPCR PCR-based genotyping General science
Updated : Mon, September 19, 2022 @ 2:12 PM
Single Nucleotide Polymorphisms (SNPs) have been widely studied for over 15 years, and have applications in...
Molecular diagnostics NGS-based genotyping Nucleic acid extraction
Our scientists and product specialists work in close collaboration with a diverse range of customers to find solutions that meet their precise needs. Our...
Genomics Nucleic acid therapeutics
Dozens of oligonucleotide-based therapeutics are already on the market, helping to treat a range of life-threatening conditions. As we explored in our previous...
Genomics Nucleic acid therapeutics
With the rapid deployment of the mRNA COVID-19 vaccines and the recent approval of the first CRISPR gene therapy, the range of oligonucleotide-based...
qPCR PCR-based genotyping oligos probes and primers
Need high specificity and shorter probes for your hybridisation assays? If you are considering Minor Groove Binder (MGB) Probes for your applications, here are...
Oligo synthesis and modifications qPCR NGS-based genotyping KASP CPG
Our scientists can’t agree!
Our portfolio covers a wide range of products supporting research, development and manufacturing across the life sciences,...
Oligo synthesis and modifications
The "Know your oligo mod" series continues with a deep dive into the 2'-O-methoxyethyl (2'-MOE) modification, a majoradvance in oligonucleotide therapeutic...
Oligo synthesis and modifications
In this latest instalment of our 'Know Your Oligo Mod' blog series, we explore the benefits of high-performance ATTO fluorescent dyes for labelling...
Oligo synthesis and modifications
In November 2023, the UK became the first country in the world to approve a gene therapy based on CRISPR-Cas9 technology. This Nobel prize-winning technique...
Molecular diagnostics Genomics
Image credit: HIV Reverse Transcriptase. RCSB Protein Data Bank. The Wellcome Collection.
Oligo synthesis and modifications Nucleic acid therapeutics
Oligo synthesis and modifications General science
Labelling, linking or modifying biomolecules used to be a laborious process, requiring customised complex synthetic pathways that yield little product....
Oligo synthesis and modifications Nucleic acid therapeutics
Molecular diagnostics Nucleic acid extraction
Molecular diagnostics Oligo synthesis and modifications qPCR General science
Updated : Fri, May 5, 2023 @ 2:34 PM
How does a BHQ dye contribute to producing superior data from your assays?
Oligo synthesis and modifications Nucleic acid therapeutics
Updated : Mon, June 26, 2023 @ 10:24 AM
Oligonucleotide therapeutics have unlocked new treatment possibilities for rare and fatal diseases often associated...
Oligo synthesis and modifications General science
Updated : Tue, May 9, 2023 @ 10:51 AM
In the next edition of the “Know your oligo mod” series, we look at a universal base analogue for oligonucleotide...
Molecular diagnostics Oligo synthesis and modifications
Updated : Tue, May 9, 2023 @ 11:01 AM
Originally developed in the early 1990s, aptamers have long been heralded as an antibody alternative for detection...
Molecular diagnostics Nucleic acid extraction General science
Updated : Tue, May 9, 2023 @ 11:05 AM
Molecular testing protocols for pathogen detection and diagnosing human diseases require reliable and high-quality...
Updated : Wed, December 14, 2022 @ 1:54 PM
When the polymerase chain reaction (PCR) was first described, the Klenow fragment of Escherichia coli DNA...
Oligo synthesis and modifications Nucleic acid therapeutics General science
Updated : Tue, August 9, 2022 @ 7:10 PM
New approaches that use aptamers as targeting agents may open the door to wider clinical use in the future
Molecular diagnostics Oligo synthesis and modifications qPCR General science
Updated : Tue, May 9, 2023 @ 10:40 AM
Let the application be your guide when deciding between LNA, MGB and BHQplus
The many different chemistries available...
SARS-CoV-2 Nucleic acid extraction Disease detection General science
Updated : Fri, December 16, 2022 @ 3:39 PM
Since early 2020, diagnostic laboratories have had to manage patient sample quantities being in a state of flux....
Molecular diagnostics qPCR General science
Updated : Wed, March 30, 2022 @ 4:00 PM
While both centralised and decentralised molecular diagnostics (MDx) testing models play an important role in patient...
Oligo synthesis and modifications Nucleic acid therapeutics
Updated : Tue, March 21, 2023 @ 3:46 PM
This is the second blog in a two-part series exploring how oligonucleotide modifications can support the advancement of...
Agrigenomics qPCR PCR-based genotyping General science
Updated : Wed, March 9, 2022 @ 1:05 AM
African oil palm (Elaeis guineensis Jacq.) is a highly productive perennial crop that is used widely in food, medicines,...
Molecular diagnostics qPCR General science
Updated : Fri, April 15, 2022 @ 8:58 PM
The COVID-19 pandemic has accelerated the uptake of point of care testing (POCT), with simple, user-administered tests...
Oligo synthesis and modifications Nucleic acid therapeutics
Updated : Tue, March 21, 2023 @ 3:44 PM
This is the first blog post in a two-part series exploring how oligonucleotide modifications can support the...
qPCR SARS-CoV-2 General science
Updated : Fri, February 11, 2022 @ 10:58 PM
But measurement science could help steer us in a better, more informed direction
COVID-19 tests can indicate the...
Oligo synthesis and modifications
Updated : Tue, January 25, 2022 @ 8:30 PM
More innovative applications for Black Hole Quencher (BHQ) dyes
In imaging and detection assay development,...
Updated : Wed, March 22, 2023 @ 1:23 PM
Stellaris controls, who needs ‘em? We all do. Especially if it’s your first time interrogating a sample with a new...
Agrigenomics qPCR PCR-based genotyping
Updated : Thu, January 12, 2023 @ 5:10 PM
Rice is the primary staple for more than half the world's population.1 With so many people relying on the crop for...
Oligo synthesis and modifications General science
Updated : Wed, December 14, 2022 @ 4:45 PM
This is the final blog post in a three-part educational series about best practices for in-house oligonucleotide...
Molecular diagnostics Oligo synthesis and modifications
Updated : Tue, January 25, 2022 @ 10:23 PM
This is the first blog post in a two-part series highlighting how Black Hole Quencher™ dyes can be incorporated into...
Oligo synthesis and modifications General science
Updated : Wed, December 14, 2022 @ 4:43 PM
This is the second blog post in a three-part educational series about best practices for in-house oligonucleotide...
Updated : Thu, February 3, 2022 @ 6:10 PM
When results from your qPCR assays aren’t quite what you expected, it can be challenging to understand what went...
Molecular diagnostics qPCR SARS-CoV-2 General science
Updated : Thu, March 31, 2022 @ 3:24 PM
In September 2021, Delta persists as the most prevalent variant worldwide1 due to its high infectivity, causing surges...
Oligo synthesis and modifications General science
Updated : Wed, December 14, 2022 @ 4:43 PM
This is the first blog post in a three-part educational series about best practices for in-house oligonucleotide...
Agrigenomics PCR-based genotyping Nucleic acid extraction
Updated : Tue, September 7, 2021 @ 7:59 PM
Aquaculture breeding programmes adopt genomic technologies, including genotyping, to increase genetic gain for...
Agrigenomics Next generation sequencing (NGS) Nucleic acid extraction
Updated : Thu, August 12, 2021 @ 11:51 PM
Informed plant breeding decisions help drive the field of agrigenomics towards ever-increasing agricultural...
Agrigenomics Nucleic acid extraction
Updated : Wed, August 4, 2021 @ 9:34 PM
A common mistake when initiating an agrigenomics project is failing to consider specific sample composition before...
Agrigenomics Genomics General science
Updated : Wed, December 14, 2022 @ 1:44 PM
The global demand for fish and fish products continues to increase as consumers focus on health-conscious ways to...
Molecular diagnostics Genomics SARS-CoV-2 General science
Updated : Thu, March 9, 2023 @ 5:37 PM
As the global population gains greater access to vaccines for COVID-19, scientists and health officials continue to...
Agrigenomics Genomics NGS-based genotyping
Updated : Fri, November 20, 2020 @ 5:16 PM
In breeding programmes, selections based on a single or small number of markers to target traits in marker assisted...
Molecular diagnostics Genomics SARS-CoV-2 General science
Updated : Thu, February 3, 2022 @ 4:39 PM
Clinical and diagnostic labs worldwide are still experiencing supply chain challenges with their SARS-CoV-2 testing...
Updated : Wed, October 7, 2020 @ 4:33 PM
“In July of 2015, I was a member of the radish genome project team. My task was to examine genetic diversity of radish...
Agrigenomics Genomics PCR-based genotyping
Updated : Fri, September 11, 2020 @ 9:52 PM
Darshna "Dusty" Vyas has been a Senior Scientist at LGC specialising in plant genetics for the past 8 years Her...
Molecular diagnostics Genomics SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:45 PM
Following up with the panelists from our recent COVID-19 webinar, Part 3 of 3
In the previous two blog posts in this...
Molecular diagnostics Genomics SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:42 PM
Following up with the panelists from our recent COVID-19 webinar, Part 2 of 3
In the face of a rapidly evolving...
Molecular diagnostics Genomics SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:45 PM
Following up with the panelists from our recent COVID-19 webinar, Part 1 of 3
The COVID-19 pandemic has presented...
Molecular diagnostics Genomics qPCR SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:44 PM
As countries worldwide begin to ease lockdown restrictions during the pandemic and prepare to return to “normal”...
Agrigenomics Genomics PCR-based genotyping
Updated : Tue, July 14, 2020 @ 1:30 PM
Brassica rapa crops are important sources of food, feed, and fuel in many parts of the world and provide a unique...
Molecular diagnostics Genomics qPCR SARS-CoV-2
Updated : Fri, December 18, 2020 @ 8:49 PM
It may seem strange that a company known for transforming the global seed breeding industry is uniquely positioned...
Molecular diagnostics Oligo synthesis and modifications Genomics SARS-CoV-2 General science
Updated : Wed, March 22, 2023 @ 1:52 PM
We’re not rejecting you, just your oligo
PCR is arguably one of the most enabling technologies of modern molecular...
Genomics Next generation sequencing (NGS) NGS-based genotyping
Updated : Wed, April 1, 2020 @ 8:12 PM
Back in September 2018, LGC acquired Lucigen Corporation. The ISO accredited site is based in Middleton, Wisconsin and...
Molecular diagnostics Oligo synthesis and modifications Genomics SARS-CoV-2
Updated : Tue, October 6, 2020 @ 6:44 PM
In the nearly three months since the first confirmed case of COVID-19, the outbreak has become a global crisis, with...
Molecular diagnostics Genomics SARS-CoV-2 General science
Updated : Tue, March 21, 2023 @ 3:41 PM
*Since the original publication of this blog, LGC Biosearch Technologies is now the only acceptable commercial supplier...
Molecular diagnostics Genomics SARS-CoV-2
Genomics PCR-based genotyping NGS-based genotyping
Updated : Mon, January 13, 2020 @ 5:08 PM
Best practice in sample collection for SeqSNP targeted genotyping by sequencing projects
When good goes in, great...
Agrigenomics Genomics Next generation sequencing (NGS) NGS-based genotyping
Updated : Wed, May 1, 2019 @ 3:59 PM
Livestock supports the livelihoods and food security of almost 1.3 billion people worldwide, contributing 40% of the...
Updated : Fri, March 29, 2019 @ 4:39 PM
We've heard it said for years, "TV will rot your brain". But in the case of our three colleagues below, that definitely...
Updated : Wed, January 9, 2019 @ 5:03 PM
Genomic selection: 6 factors to consider when choosing between targeted GBS and microarrays
Updated : Mon, September 19, 2022 @ 2:14 PM
While the science of pharmacogenomics has been around for years, its popularity is starting to pick up steam as...
Genomics Nucleic acid extraction
Updated : Thu, June 28, 2018 @ 4:28 PM
Imagine a time capsule the size of a shoebox that holds all the information currently on the internet that can be stored...
Updated : Tue, May 29, 2018 @ 3:47 PM
Ever wake up in the morning just feeling like a rock star, or maybe like Francis Crick, Rosalind Franklin or Maurice...
Updated : Mon, April 30, 2018 @ 1:53 PM
To truly understand complex diseases such as cancer, scientists need access to tools that don’t just average data...
Updated : Thu, March 29, 2018 @ 4:00 PM
Ask any little girl what they want to be when they grow up and you may hear things like, princess, ballerina, pop star,...
Updated : Tue, January 16, 2018 @ 4:50 PM
Stellaris® RNA FISH (fluorescence in situ hybridization) is an RNA visualization method that allows simultaneous...
Agrigenomics Genomics NGS-based genotyping General science
Updated : Mon, September 19, 2022 @ 2:16 PM
With the global population predicted to reach 9 billion people within the next 35 years, we will need to double the...
Agrigenomics Genomics PCR-based genotyping
Updated : Wed, November 22, 2017 @ 1:44 PM
Wheat is one of the three most important crops for human and livestock feed. With an ever-increasing global...
Agrigenomics Genomics PCR-based genotyping
Updated : Tue, July 10, 2018 @ 9:08 PM
Our world population is growing at a tremendous rate and by 2050, Africa’s population alone is set to hit over 2.5...
Genomics PCR-based genotyping Disease detection General science
Updated : Mon, September 19, 2022 @ 2:14 PM
3.2 billion people across 106 countries and territories, live in areas at risk of malaria transmission. The serious...
RNA FISH Genomics General science
Updated : Thu, July 6, 2017 @ 3:22 PM
Recently LGC Genomics hosted a lunch and learn Stellaris® seminar at the Helen Diller Cancer Institute at UCSF with our...
Updated : Mon, September 19, 2022 @ 2:07 PM
LGC's Genomics Division has signed a memorandum of understanding (MOU) with Chinese health management expert...
RNA FISH Disease detection General science
Updated : Mon, March 6, 2017 @ 4:37 PM
New research has, for the first time, found evidence suggesting the molecular epidemiology of how the Zika virus spreads...
Genomics PCR-based genotyping General science
Updated : Wed, February 15, 2017 @ 4:23 PM
Demand for maize is increasing due to an increased number of people transitioning to meat-based diets driving demand...
Updated : Mon, September 19, 2022 @ 2:05 PM
The advent of and ongoing improvements to next-generation sequencing technologies is driving the continuing and...
Updated : Mon, January 23, 2017 @ 4:27 PM
Nature versus nurture. It’s a tale as old as time.
When Craig Venter made the comment after the human genome sequence...
Agrigenomics Genomics PCR-based genotyping NGS-based genotyping General science
Updated : Wed, January 18, 2017 @ 2:13 PM
Many areas critical to improved agricultural production require robust and scalable genotyping platforms to enable...
Updated : Mon, September 19, 2022 @ 2:15 PM
It seems everyone wants to do more with less, and automate the process as well. But this can cause a number of...
RNA FISH Genomics General science
Updated : Mon, September 19, 2022 @ 2:12 PM
It wouldn't be fair to close out 2016 without showcasing the stellar year that Stellaris® RNA FISH has had. Take a...
Updated : Mon, November 28, 2016 @ 11:31 PM
The secret of life. That’s what Francis Crick and James Watson claimed they had discovered back in Cambridge,...
Updated : Mon, November 21, 2016 @ 3:32 PM
In the early 1900s, scientists found that the function of genes was to make proteins, disproving the earlier idea...
Updated : Wed, March 29, 2023 @ 10:51 AM
The strands of DNA in your cells are organized into pieces called chromosomes. Chromosomes are further organized into...
Updated : Mon, September 19, 2022 @ 2:13 PM
Researchers from the Baker IDI Heart and Diabetes Institute in Melbourne, Australia have blamed a default...
Updated : Wed, March 29, 2023 @ 11:04 AM
As the Zika virus outbreak spreads, a wave of international concern has grown, and scientists have scrambled to...
Oligo synthesis and modifications General science
Updated : Wed, March 29, 2023 @ 10:55 AM
Thio C6 Linker (Thiohexyl)
We continue our “Know Your Oligo Mod” series with another versatile custom oligonucleotide...
Molecular diagnostics Oligo synthesis and modifications qPCR General science
Updated : Wed, December 14, 2022 @ 5:04 PM
OLIGO SYNTHESIS PHOTO GLIMPSE
We’ve recently captured our talented manufacturing teams hard at work building...
Updated : Wed, August 16, 2017 @ 9:15 AM
Here is the final installment of our “Imaging Stellaris Assays” blog series. In our two previous posts, we’ve gone...
Updated : Tue, September 27, 2022 @ 2:32 PM
Stellaris® RNA FISH is a novel technology that allows for the detection of single or clustered RNAs in fixed cells...
Oligo synthesis and modifications qPCR General science
Updated : Wed, March 29, 2023 @ 10:54 AM
This week, we continue our Know your oligo mod blog series and we will focus on a very basic, yet extremely versatile...
Updated : Wed, August 16, 2017 @ 9:13 AM
Here we continue our “Imaging Stellaris Assays” blog series. We last left off talking about the most important...
Updated : Tue, March 21, 2023 @ 3:53 PM
The cleavage and polyadenylation event, the final trimming in the molecular mRNA barbershop, normally releases both the...
Updated : Wed, August 16, 2017 @ 9:42 PM
Stellaris® FISH is an RNA detection technology performed by means of in situ hybridization. This technology and all of...
Oligo synthesis and modifications General science
Updated : Wed, March 29, 2023 @ 10:38 AM
Chemically synthesized DNA has become an indispensable tool for molecular biologists in the fields of medicine,...
Oligo synthesis and modifications General science
Updated : Fri, January 13, 2023 @ 11:35 AM
In this instalment, we will cover the basics of LGC Biosearch Technologies’ line of proprietary non-fluorescent...
Updated : Fri, November 13, 2015 @ 9:25 PM
Studying the expression level of RNA transcripts is often complicated by the fact that many DNA sequences are...