More innovative applications for Black Hole Quencher (BHQ) dyes In imaging and detection assay development, innovative ...
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Considerations for RT-qPCR in molecular point of care testing devices
The COVID-19 pandemic has accelerated the uptake of point of care testing (POCT), with simple, user-administered tests becoming commonplace in schools, places of work and people’s homes. Antigen POCT has been pivotal in SARS-CoV-2 detection, particularly where reverse transcription PCR (RT-PCR) cannot be delivered in a timely manner. However, the use of antigen tests isn’t always appropriate due to variable sensitivity. RT-PCR – or RT-qPCR if using real-time detection – offers greater sensitivity and specificity. Leveraging this technology in POCT brings lab quality results to the point of need, providing rapid, accurate and actionable results to clinicians.
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This is the first blog post in a two-part series highlighting how Black Hole Quencher™ dyes can be incorporated into ...
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Topics: Molecular Diagnostics, Oligo Modifications
We continue our “Know Your Oligo Mod” series with another versatile custom oligonucleotide modification: the Thio C6 ...
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Topics: Oligo Modifications
This week, we continue our Know Your Oligo Mod series and we will focus on a very basic, yet extremely versatile ...
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Topics: Real-time PCR, Oligo Modifications
This post in our continuing series, “Know your oligo mod” will cover phosphorothioate bonds, which are available for ...
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Topics: Custom Oligos, Oligo Modifications
The chemical synthesis of oligonucleotides allows for the incorporation of a wealth of modifications to an oligo ...
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Topics: Custom Oligos, Oligo Modifications