The BiosearchTech Blog

Buddy Up: The Double Helix

Posted on Mon, Nov 28, 2016 @ 07:15 AM

The secret of life. That’s what Francis Crick and James Watson claimed they had discovered back in Cambridge, England on February 28, 1953. Only 36 and 24-years-old respectively, the two scientists were met with skepticism when they brought up their theory of what the structure of DNA looked like.

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Topics: Genomics

Genes, Proteins & DNA: Our Hereditary Software

Posted on Mon, Nov 21, 2016 @ 07:17 AM

In the early 1900s, scientists found that the function of genes was to make proteins, disproving the earlier idea that genes make proteins themselves. This greatly impacted medical treatment. While it is difficult to change a defective gene that causes disease, some genetic conditions can be treated more directly by replacing a missing protein. For example, hemophiliacs can be treated with a blood-clotting enzyme that their bodies, due to their genes, cannot produce themselves.

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Topics: Genomics

"X" Marks the Spot: A Closer Look at Chromosomes

Posted on Mon, Nov 14, 2016 @ 07:28 AM

The strands of DNA in your cells are organized into pieces called chromosomes. Chromosomes are further organized into short segments of DNA called genes. If you imagine your DNA as a cookbook, then your genes are the recipes and the chromosomes are the ingredients.

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Topics: Genomics

The Art of Neuroscience

Posted on Tue, Oct 11, 2016 @ 12:17 PM

Neuroscientists are renowned for working across a number of fields spanning the life sciences and social sciences as well as engineering and mathematics. An area that is rarely acknowledged is that many of the latest discoveries of how the brain works at the molecular level are incredibly artistic.

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Topics: Genomics, Contest, Neuroscience

Excel Autocorrect Fails the Genomics Community - Are your Results Excellent or Excel-not?

Posted on Thu, Sep 08, 2016 @ 09:30 AM

Researchers from the Baker IDI Heart and Diabetes Institute in Melbourne, Australia have blamed a default autocorrect function within Microsoft Excel for errors in supplementary files associated with approximately one-fifth of all academic genomics papers.

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Topics: Genomics, Data, Research

qPCR-based Molecular Diagnostics at the Forefront of Zika Surveillance

Posted on Tue, Aug 23, 2016 @ 02:00 PM

As the Zika virus outbreak spreads, a wave of international concern has grown, and scientists have scrambled to overcome the significant challenge of diagnosing the virus so it can be treated effectively. Fortunately, a new multiplexed-qPCR assay using Dual-Labeled BHQ® probes from LGC Biosearch Technologies has recently been developed that can distinguish between Zika and other viral infections that cause similar symptoms.

Zika is a single-stranded RNA arbovirus, spread by the Aedes aegypti and Ae. albopictus mosquitoes1. These mosquito species are also the same vectors that spread other viral pathogens such as Chikungunya and Dengue, both of which can present similar symptoms as those of Zika. It’s been a true clinical challenge to diagnose and differentiate between Chikungunya, Dengue, and Zika infections.

On February 1, 2016 the World Health Organization (WHO) released a statement of public health concerns over a link between Zika virus and prevalence of microcephaly in the offspring of infected individuals2. Of all the South American countries affected by Zika, Brazil has been hardest hit, with an estimated 1.5 million cases since 20153. Subsequent to the announcement, concern has grown internationally due to the 2016 Olympic games in Rio de Janeiro, Brazil, coinciding with the outbreak. Recently, Centers for Disease Control and Prevention (CDC) issued a historic travel advisory relating to the continental United States due to localized transmission within a region of Miami, FL4,5. Zika cases have also been reported in numerous other US locations, particularly in the territory of Puerto Rico which is under a public health emergency as of August 12, 2016 (see inset map).  CDC advises travelers to take precautions against Zika, and recommends those experiencing symptoms to meet with their physicians6.

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Topics: Real-time PCR

Know Your Oligo Mod: Thio C6 Linker

Posted on Thu, Jul 14, 2016 @ 02:00 PM

We continue our “Know Your Oligo Mod” series with another versatile custom oligonucleotide modification: the Thio C6 Linker (Thiohexyl) modification.  Figure 1 depicts the reactive handle of a Thio C6 Linker that can be incorporated as either a 5’ modification or a 3’ modification on a custom oligonucleotide. The addition of this custom oligo modification creates a conjugation site with a reactive thiol group.

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Topics: Oligo Modifications

A Complete Ecosystem to Accelerate Breeding Programs [Infographic]

Posted on Tue, Jun 28, 2016 @ 02:00 PM

Modern breeding methods rely on the identification and utilization of molecular markers associated with traits important for plant and animal improvement. Here at LGC, we can bolster your breeding programs with a range of products and services at every step, beginning with research to selection to analysis and production. This infographic summarizes how we can accelerate breeding programs with our cost-effective agrigenomic solutions, whether it be in our labs or yours.

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Topics: Agrigenomics

DNA Technology is now LGC Biosearch Technologies

Posted on Tue, Jun 14, 2016 @ 03:52 PM

For DNA Technology’s existing customers, don’t fret! The online ordering process will remain the same, as will the team assisting you. BHQ® probes, BHQplus® probes, and custom oligos will continue to be offered at the facility in Denmark. This facility is DS/EN ISO 9001:2008 compliant and the products are intended for research and development use. For more consequential assays, GMP manufacturing is also available.

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Topics: Announcement

Photoblog: Behind the scenes of oligo synthesis

Posted on Wed, May 18, 2016 @ 03:00 PM

OLIGO
SYNTHESIS
PHOTO
GLIMPSE

We’ve recently captured our talented manufacturing teams hard at work building oligos. Please enjoy this short visual insight into LGC Biosearch Technologies.

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Topics: Molecular Diagnostics, Real-time PCR, Custom Oligos

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About Biosearch Technologies

As the inventor of the BHQ dyes, Biosearch Technologies synthesizes sophisticated oligos for real time qPCR, molecular diagnostics, and more!  Visit our home page to view our products and services.

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