You wouldn’t just read the first chapter of a book and then stop. Nor would you go to the theatre and see one act of a play and then leave. Same was true for DNA sequencing. Once scientists began to reveal human genes in the 1980s, they began to wonder, why not expose the entire human genetic code?Read More
The BiosearchTech Blog
It wouldn't be fair to close out 2016 without showcasing the stellar year that Stellaris® RNA FISH has had. Take a closer look at our top 10 highlights from the past year - mind blowing images are only the beginning!Read More
With the discovery of the double helix, we learned how genes are copied and how genetic information was passed on. From there, Francis Crick, Marhsall Nirenberg and Jacques Monod, cracked the genetic code and discovered how genes perform other vital tasks besides copying themselves. Unlocking this code brought about Hermann Muller’s realization that there could be a possibility to introduce mutations, allowing humanity to direct evolution in desirable ways.Read More
The secret of life. That’s what Francis Crick and James Watson claimed they had discovered back in Cambridge, England on February 28, 1953. Only 36 and 24-years-old respectively, the two scientists were met with skepticism when they brought up their theory of what the structure of DNA looked like.Read More
In the early 1900s, scientists found that the function of genes was to make proteins, disproving the earlier idea that genes make proteins themselves. This greatly impacted medical treatment. While it is difficult to change a defective gene that causes disease, some genetic conditions can be treated more directly by replacing a missing protein. For example, hemophiliacs can be treated with a blood-clotting enzyme that their bodies, due to their genes, cannot produce themselves.Read More
The strands of DNA in your cells are organized into pieces called chromosomes. Chromosomes are further organized into short segments of DNA called genes. If you imagine your DNA as a cookbook, then your genes are the recipes and the chromosomes are the ingredients.Read More
Neuroscientists are renowned for working across a number of fields spanning the life sciences and social sciences as well as engineering and mathematics. An area that is rarely acknowledged is that many of the latest discoveries of how the brain works at the molecular level are incredibly artistic.Read More
Researchers from the Baker IDI Heart and Diabetes Institute in Melbourne, Australia have blamed a default autocorrect function within Microsoft Excel for errors in supplementary files associated with approximately one-fifth of all academic genomics papers.Read More
As the Zika virus outbreak spreads, a wave of international concern has grown, and scientists have scrambled to overcome the significant challenge of diagnosing the virus so it can be treated effectively. Fortunately, a new multiplexed-qPCR assay using Dual-Labeled BHQ® probes from LGC Biosearch Technologies has recently been developed that can distinguish between Zika and other viral infections that cause similar symptoms.
Zika is a single-stranded RNA arbovirus, spread by the Aedes aegypti and Ae. albopictus mosquitoes1. These mosquito species are also the same vectors that spread other viral pathogens such as Chikungunya and Dengue, both of which can present similar symptoms as those of Zika. It’s been a true clinical challenge to diagnose and differentiate between Chikungunya, Dengue, and Zika infections.
On February 1, 2016 the World Health Organization (WHO) released a statement of public health concerns over a link between Zika virus and prevalence of microcephaly in the offspring of infected individuals2. Of all the South American countries affected by Zika, Brazil has been hardest hit, with an estimated 1.5 million cases since 20153. Subsequent to the announcement, concern has grown internationally due to the 2016 Olympic games in Rio de Janeiro, Brazil, coinciding with the outbreak. Recently, Centers for Disease Control and Prevention (CDC) issued a historic travel advisory relating to the continental United States due to localized transmission within a region of Miami, FL4,5. Zika cases have also been reported in numerous other US locations, particularly in the territory of Puerto Rico which is under a public health emergency as of August 12, 2016 (see inset map). CDC advises travelers to take precautions against Zika, and recommends those experiencing symptoms to meet with their physicians6.Read More
Topics: Real-time PCR
We continue our “Know Your Oligo Mod” series with another versatile custom oligonucleotide modification: the Thio C6 Linker (Thiohexyl) modification. Figure 1 depicts the reactive handle of a Thio C6 Linker that can be incorporated as either a 5’ modification or a 3’ modification on a custom oligonucleotide. The addition of this custom oligo modification creates a conjugation site with a reactive thiol group.Read More
Topics: Oligo Modifications